rs2583435

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0305 (8589/28082,GnomAD)
C=0392 (1965/5008,1000G)
C=0293 (1130/3854,ALSPAC)
C=0278 (1032/3708,TWINSUK)
chr11:2937588 (GRCh38.p7) (11p15.4)
AD
GWASdb2
2   publication(s)
See rs on genome
100 Enhancers around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.2937588T>C
GRCh37.p13 chr 11NC_000011.9:g.2958818T>C
GRCh38.p7 chr 11 alt locus HSCHR11_1_CTG7NT_187585.1:g.168246C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.748C=0.252
1000GenomesAmericanSub694T=0.520C=0.480
1000GenomesEast AsianSub1008T=0.331C=0.669
1000GenomesEuropeSub1006T=0.729C=0.271
1000GenomesGlobalStudy-wide5008T=0.608C=0.392
1000GenomesSouth AsianSub978T=0.640C=0.360
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.707C=0.293
The Genome Aggregation DatabaseAfricanSub8646T=0.636C=0.364
The Genome Aggregation DatabaseAmericanSub822T=0.460C=0.540
The Genome Aggregation DatabaseEast AsianSub1606T=0.304C=0.696
The Genome Aggregation DatabaseEuropeSub16798T=0.771C=0.228
The Genome Aggregation DatabaseGlobalStudy-wide28082T=0.694C=0.305
The Genome Aggregation DatabaseOtherSub210T=0.800C=0.200
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.722C=0.278
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
24068962Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.O'Seaghdha CMPLoS Genet

P-Value

SNP ID p-value Traits Study
rs25834350.0001alcohol dependence(early age of onset)20201924
rs25834350.00071alcohol dependence20201924

eQTL of rs2583435 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2583435 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1129662952967764E0677477
chr1130034183003948E06744600
chr1130044323004472E06745614
chr1130044753004606E06745657
chr1130083713008482E06749553
chr1130085403008614E06749722
chr1129648972964968E0686079
chr1129662952967764E0687477
chr1129680632968136E0689245
chr1129690922969179E06810274
chr1130034183003948E06844600
chr1130044323004472E06845614
chr1130044753004606E06845657
chr1130046313004681E06845813
chr1130047883004842E06845970
chr1129662952967764E0697477
chr1129968922997117E06938074
chr1129971372997477E06938319
chr1129975392997788E06938721
chr1129978042998183E06938986
chr1130034183003948E06944600
chr1130044323004472E06945614
chr1130044753004606E06945657
chr1130046313004681E06945813
chr1130047883004842E06945970
chr1130083713008482E06949553
chr1129662952967764E0707477
chr1130033003003360E07044482
chr1130034183003948E07044600
chr1129304342930499E071-28319
chr1129305022930654E071-28164
chr1129308512931035E071-27783
chr1129612242962992E0712406
chr1129659982966209E0717180
chr1129662952967764E0717477
chr1129680632968136E0719245
chr1130034183003948E07144600
chr1130044323004472E07145614
chr1130044753004606E07145657
chr1130046313004681E07145813
chr1130047883004842E07145970
chr1130049403004995E07146122
chr1130083713008482E07149553
chr1130085403008614E07149722
chr1129662952967764E0727477
chr1129680632968136E0729245
chr1129860272986242E07227209
chr1129863492986409E07227531
chr1129968922997117E07238074
chr1129971372997477E07238319
chr1129975392997788E07238721
chr1129978042998183E07238986
chr1130024623002554E07243644
chr1130026943002744E07243876
chr1130030563003286E07244238
chr1130033003003360E07244482
chr1130034183003948E07244600
chr1130044323004472E07245614
chr1130044753004606E07245657
chr1130046313004681E07245813
chr1130047883004842E07245970
chr1130049403004995E07246122
chr1129649882965377E0736170
chr1129654892965649E0736671
chr1129657452965809E0736927
chr1129658372965970E0737019
chr1129659982966209E0737180
chr1129662952967764E0737477
chr1129975392997788E07338721
chr1129978042998183E07338986
chr1130030563003286E07344238
chr1130033003003360E07344482
chr1130034183003948E07344600
chr1130081743008263E07349356
chr1130083713008482E07349553
chr1130085403008614E07349722
chr1129662952967764E0747477
chr1129999033000044E07441085
chr1130030563003286E07444238
chr1130033003003360E07444482
chr1130034183003948E07444600
chr1130044323004472E07445614
chr1130044753004606E07445657
chr1130046313004681E07445813
chr1130047883004842E07445970
chr1130049403004995E07446122
chr1130081743008263E07449356
chr1130083713008482E07449553
chr1130085403008614E07449722
chr1129111342914582E081-44236
chr1129657452965809E0816927
chr1129658372965970E0817019
chr1129659982966209E0817180
chr1129662952967764E0817477
chr1129680632968136E0819245
chr1129682072968269E0819389
chr1129683532968484E0819535
chr1129685042968589E0819686
chr1129686002968740E0819782
chr1129680632968136E0829245










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1129491552952634E073-6184