SNP Detail Info-rs2621323

Sequence Name	Change(s)
GRCh38.p7 chr 6	NC_000006.12:g.32820930A>G
GRCh37.p13 chr 6	NC_000006.11:g.32788707A>G
TAP2 RefSeqGene	NG_009793.3:g.22841T>C
HLA-DOB RefSeqGene	NG_012008.1:g.1119T>C
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_COX_CTG1	NT_113891.3:g.4233131A>G
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1	NT_113891.2:g.4233237A>G
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_MCF_CTG1	NT_167247.2:g.4120018A>G
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1	NT_167247.1:g.4125603A>G
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_QBL_CTG1	NT_167248.2:g.4015218A>G
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1	NT_167248.1:g.4020814A>G
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_DBB_CTG1	NT_167245.2:g.4064648G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1	NT_167245.1:g.4070233G>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1	NT_167249.2:g.4220332G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1	NT_167249.1:g.4219630G>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_MANN_CTG1	NT_167246.2:g.4240283A>G
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1	NT_167246.1:g.4245903A>G
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_APD_CTG1	NT_167244.2:g.4125944G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_APD_CTG1	NT_167244.1:g.4075860G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.593	G=0.407
1000Genomes	American	Sub	694	A=0.600	G=0.400
1000Genomes	East Asian	Sub	1008	A=0.573	G=0.427
1000Genomes	Europe	Sub	1006	A=0.655	G=0.345
1000Genomes	Global	Study-wide	5008	A=0.572	G=0.428
1000Genomes	South Asian	Sub	978	A=0.440	G=0.560
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.707	G=0.293
The Genome Aggregation Database	African	Sub	8694	A=0.616	G=0.384
The Genome Aggregation Database	American	Sub	838	A=0.550	G=0.450
The Genome Aggregation Database	East Asian	Sub	1600	A=0.616	G=0.384
The Genome Aggregation Database	Europe	Sub	18450	A=0.652	G=0.347
The Genome Aggregation Database	Global	Study-wide	29884	A=0.636	G=0.363
The Genome Aggregation Database	Other	Sub	302	A=0.560	G=0.440
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.626	G=0.373
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.718	G=0.282

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs2621323	0.00041	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.9928e-14	3882	Cerebellum
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	4.7721e-11	3882	Frontal_Cortex_BA9
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.1851e-8	3882	Hypothalamus
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.0541e-13	3882	Cortex
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.6154e-9	3882	Cerebellar_Hemisphere
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.9928e-11	3882	Caudate_basal_ganglia
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.8342e-4	3882	Brain_Spinal_cord_cervical
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.0737e-7	3882	Hippocampus
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	1.4959e-4	3882	Substantia_nigra
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	6.9503e-9	3882	Putamen_basal_ganglia
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	5.3216e-6	3882	Anterior_cingulate_cortex
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	2.6012e-10	3882	Nucleus_accumbens_basal_ganglia
Chr6:32788707	HLA-DOB	ENSG00000241106.2	A>G	4.9962e-4	3882	Amygdala

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr6	32793769	32794052	E067	5062
chr6	32804710	32804798	E067	16003
chr6	32813824	32813885	E068	25117
chr6	32813888	32814070	E068	25181
chr6	32819740	32819875	E068	31033
chr6	32819740	32819875	E069	31033
chr6	32793769	32794052	E071	5062
chr6	32794257	32794358	E071	5550
chr6	32819740	32819875	E071	31033
chr6	32793769	32794052	E072	5062
chr6	32794257	32794358	E072	5550
chr6	32819740	32819875	E072	31033
chr6	32794257	32794358	E073	5550
chr6	32804710	32804798	E073	16003
chr6	32819740	32819875	E073	31033
chr6	32810536	32810768	E074	21829
chr6	32819740	32819875	E074	31033
chr6	32835790	32836343	E074	47083

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr6	32805737	32806948	E067	17030
chr6	32811034	32813766	E067	22327
chr6	32820332	32820414	E067	31625
chr6	32820435	32822762	E067	31728
chr6	32805737	32806948	E068	17030
chr6	32811034	32813766	E068	22327
chr6	32820332	32820414	E068	31625
chr6	32820435	32822762	E068	31728
chr6	32805737	32806948	E069	17030
chr6	32811034	32813766	E069	22327
chr6	32820332	32820414	E069	31625
chr6	32820435	32822762	E069	31728
chr6	32805737	32806948	E070	17030
chr6	32811034	32813766	E070	22327
chr6	32820332	32820414	E070	31625
chr6	32820435	32822762	E070	31728
chr6	32805737	32806948	E071	17030
chr6	32811034	32813766	E071	22327
chr6	32820332	32820414	E071	31625
chr6	32820435	32822762	E071	31728
chr6	32805737	32806948	E072	17030
chr6	32811034	32813766	E072	22327
chr6	32820332	32820414	E072	31625
chr6	32820435	32822762	E072	31728
chr6	32805737	32806948	E073	17030
chr6	32811034	32813766	E073	22327
chr6	32820332	32820414	E073	31625
chr6	32820435	32822762	E073	31728
chr6	32805737	32806948	E074	17030
chr6	32811034	32813766	E074	22327
chr6	32820332	32820414	E074	31625
chr6	32820435	32822762	E074	31728
chr6	32805737	32806948	E082	17030
chr6	32811034	32813766	E082	22327
chr6	32820435	32822762	E082	31728

rs2621323