rs2635190

Homo sapiens
C>T
LINC01378 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0433 (12805/29528,GnomAD)
C==0379 (11042/29118,TOPMED)
T=0496 (2483/5008,1000G)
C==0484 (1866/3854,ALSPAC)
C==0476 (1766/3708,TWINSUK)
chr4:117512484 (GRCh38.p7) (4q26)
AD
GWASdb2
1   publication(s)
See rs on genome
1 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.117512484C>T
GRCh37.p13 chr 4NC_000004.11:g.118433639C>T

Gene: LINC01378, long intergenic non-protein coding RNA 1378(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LINC01378 transcriptNR_125757.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.176T=0.824
1000GenomesAmericanSub694C=0.620T=0.380
1000GenomesEast AsianSub1008C=0.777T=0.223
1000GenomesEuropeSub1006C=0.508T=0.492
1000GenomesGlobalStudy-wide5008C=0.504T=0.496
1000GenomesSouth AsianSub978C=0.580T=0.420
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.484T=0.516
The Genome Aggregation DatabaseAfricanSub8624C=0.212T=0.788
The Genome Aggregation DatabaseAmericanSub768C=0.620T=0.380
The Genome Aggregation DatabaseEast AsianSub1582C=0.776T=0.224
The Genome Aggregation DatabaseEuropeSub18254C=0.501T=0.499
The Genome Aggregation DatabaseGlobalStudy-wide29528C=0.433T=0.566
The Genome Aggregation DatabaseOtherSub300C=0.440T=0.560
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.379T=0.620
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.476T=0.524
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs26351900.000829alcohol consumption (maxi-drinks)24277619

eQTL of rs2635190 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2635190 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4118449393118449507E08115754