rs2645077

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0251 (7528/29904,GnomAD)
G==0293 (8558/29118,TOPMED)
G==0359 (1797/5008,1000G)
G==0198 (764/3854,ALSPAC)
G==0211 (784/3708,TWINSUK)
chr1:2317797 (GRCh38.p7) (1p36.32)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.2317797G>A
GRCh37.p13 chr 1NC_000001.10:g.2249236G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.387A=0.613
1000GenomesAmericanSub694G=0.230A=0.770
1000GenomesEast AsianSub1008G=0.409A=0.591
1000GenomesEuropeSub1006G=0.223A=0.777
1000GenomesGlobalStudy-wide5008G=0.359A=0.641
1000GenomesSouth AsianSub978G=0.500A=0.500
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.198A=0.802
The Genome Aggregation DatabaseAfricanSub8700G=0.355A=0.645
The Genome Aggregation DatabaseAmericanSub838G=0.240A=0.760
The Genome Aggregation DatabaseEast AsianSub1612G=0.411A=0.589
The Genome Aggregation DatabaseEuropeSub18454G=0.188A=0.811
The Genome Aggregation DatabaseGlobalStudy-wide29904G=0.251A=0.748
The Genome Aggregation DatabaseOtherSub300G=0.310A=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.293A=0.706
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.211A=0.789
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs26450770.000168alcohol consumption (maxi-drinks)24277619

eQTL of rs2645077 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2645077 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr121998882199945E067-49291
chr121999782200018E067-49218
chr122001432200193E067-49043
chr122003312200381E067-48855
chr122006752200796E067-48440
chr122008642200961E067-48275
chr122009732201170E067-48066
chr122015222201576E067-47660
chr122015942201662E067-47574
chr122017092202460E067-46776
chr122026472203176E067-46060
chr122033162203524E067-45712
chr122035332203680E067-45556
chr122038322204147E067-45089
chr122041992204358E067-44878
chr122044102204460E067-44776
chr122045312204581E067-44655
chr122046772204853E067-44383
chr122050172205061E067-44175
chr122054272205499E067-43737
chr122056102205833E067-43403
chr122058652205962E067-43274
chr122060052206162E067-43074
chr122062632206379E067-42857
chr122064422206565E067-42671
chr122066702206796E067-42440
chr122072662207971E067-41265
chr122079762208112E067-41124
chr122092772209376E067-39860
chr122095662209823E067-39413
chr122098542210030E067-39206
chr122102172211564E067-37672
chr122115662211663E067-37573
chr122198642220163E067-29073
chr122202682220334E067-28902
chr122204792220542E067-28694
chr122206282220834E067-28402
chr122211192221343E067-27893
chr122214062221456E067-27780
chr122234862223537E067-25699
chr122235442223601E067-25635
chr122239592224016E067-25220
chr122240642224132E067-25104
chr122241972224515E067-24721
chr122256112225793E067-23443
chr122259272226169E067-23067
chr122299522230043E067-19193
chr122301102230215E067-19021
chr122303002230372E067-18864
chr122304042233096E067-16140
chr122331172233729E067-15507
chr122338472233970E067-15266
chr122340142234064E067-15172
chr122341162234360E067-14876
chr122360882236152E067-13084
chr122427982243602E067-5634
chr122436212247524E067-1712
chr122530932253224E0673857
chr122532622253389E0674026
chr122534552254782E0674219
chr121998882199945E068-49291
chr121999782200018E068-49218
chr122001432200193E068-49043
chr122003312200381E068-48855
chr122006752200796E068-48440
chr122008642200961E068-48275
chr122009732201170E068-48066
chr122015222201576E068-47660
chr122015942201662E068-47574
chr122017092202460E068-46776
chr122026472203176E068-46060
chr122033162203524E068-45712
chr122035332203680E068-45556
chr122038322204147E068-45089
chr122041992204358E068-44878
chr122044102204460E068-44776
chr122045312204581E068-44655
chr122046772204853E068-44383
chr122050172205061E068-44175
chr122054272205499E068-43737
chr122056102205833E068-43403
chr122058652205962E068-43274
chr122060052206162E068-43074
chr122062632206379E068-42857
chr122064422206565E068-42671
chr122066702206796E068-42440
chr122072662207971E068-41265
chr122079762208112E068-41124
chr122081582208369E068-40867
chr122092772209376E068-39860
chr122095662209823E068-39413
chr122098542210030E068-39206
chr122102172211564E068-37672
chr122115662211663E068-37573
chr122178292217920E068-31316
chr122179952218064E068-31172
chr122180882218142E068-31094
chr122182862218412E068-30824
chr122198642220163E068-29073
chr122202682220334E068-28902
chr122204792220542E068-28694
chr122206282220834E068-28402
chr122211192221343E068-27893
chr122234862223537E068-25699
chr122235442223601E068-25635
chr122239592224016E068-25220
chr122240642224132E068-25104
chr122241972224515E068-24721
chr122246552224788E068-24448
chr122248022224878E068-24358
chr122256112225793E068-23443
chr122259272226169E068-23067
chr122266502226853E068-22383
chr122270922227150E068-22086
chr122272472227389E068-21847
chr122295542229608E068-19628
chr122296262229676E068-19560
chr122297612229917E068-19319
chr122299522230043E068-19193
chr122301102230215E068-19021
chr122303002230372E068-18864
chr122304042233096E068-16140
chr122331172233729E068-15507
chr122338472233970E068-15266
chr122340142234064E068-15172
chr122341162234360E068-14876
chr122360882236152E068-13084
chr122362612237272E068-11964
chr122427982243602E068-5634
chr122436212247524E068-1712
chr122475452247627E068-1609
chr122522262252293E0682990
chr122523772253055E0683141
chr122530932253224E0683857
chr122532622253389E0684026
chr122534552254782E0684219
chr121998882199945E069-49291
chr121999782200018E069-49218
chr122001432200193E069-49043
chr122003312200381E069-48855
chr122006752200796E069-48440
chr122008642200961E069-48275
chr122009732201170E069-48066
chr122015222201576E069-47660
chr122015942201662E069-47574
chr122017092202460E069-46776
chr122026472203176E069-46060
chr122033162203524E069-45712
chr122035332203680E069-45556
chr122038322204147E069-45089
chr122041992204358E069-44878
chr122054272205499E069-43737
chr122056102205833E069-43403
chr122058652205962E069-43274
chr122060052206162E069-43074
chr122062632206379E069-42857
chr122064422206565E069-42671
chr122066702206796E069-42440
chr122072662207971E069-41265
chr122079762208112E069-41124
chr122081582208369E069-40867
chr122083882208451E069-40785
chr122087552208893E069-40343
chr122092772209376E069-39860
chr122095662209823E069-39413
chr122098542210030E069-39206
chr122102172211564E069-37672
chr122198642220163E069-29073
chr122202682220334E069-28902
chr122204792220542E069-28694
chr122206282220834E069-28402
chr122211192221343E069-27893
chr122214062221456E069-27780
chr122234862223537E069-25699
chr122235442223601E069-25635
chr122239592224016E069-25220
chr122240642224132E069-25104
chr122241972224515E069-24721
chr122246552224788E069-24448
chr122248022224878E069-24358
chr122256112225793E069-23443
chr122259272226169E069-23067
chr122266502226853E069-22383
chr122270922227150E069-22086
chr122272472227389E069-21847
chr122274322227486E069-21750
chr122278232227967E069-21269
chr122279902228378E069-20858
chr122297612229917E069-19319
chr122299522230043E069-19193
chr122301102230215E069-19021
chr122303002230372E069-18864
chr122304042233096E069-16140
chr122331172233729E069-15507
chr122338472233970E069-15266
chr122340142234064E069-15172
chr122341162234360E069-14876
chr122349712235053E069-14183
chr122350732235147E069-14089
chr122354152235489E069-13747
chr122356152235665E069-13571
chr122356902235734E069-13502
chr122360882236152E069-13084
chr122415532241630E069-7606
chr122418602242158E069-7078
chr122427982243602E069-5634
chr122436212247524E069-1712
chr122523772253055E0693141
chr122530932253224E0693857
chr122532622253389E0694026
chr122534552254782E0694219
chr121998882199945E070-49291
chr121999782200018E070-49218
chr122001432200193E070-49043
chr122003312200381E070-48855
chr122006752200796E070-48440
chr122008642200961E070-48275
chr122009732201170E070-48066
chr122015222201576E070-47660
chr122015942201662E070-47574
chr122041992204358E070-44878
chr122044102204460E070-44776
chr122045312204581E070-44655
chr122046772204853E070-44383
chr122050172205061E070-44175
chr122054272205499E070-43737
chr122056102205833E070-43403
chr122058652205962E070-43274
chr122060052206162E070-43074
chr122062632206379E070-42857
chr122064422206565E070-42671
chr122079762208112E070-41124
chr122081582208369E070-40867
chr122083882208451E070-40785
chr122092772209376E070-39860
chr122095662209823E070-39413
chr122098542210030E070-39206
chr122158032215906E070-33330
chr122160152216062E070-33174
chr122162812216331E070-32905
chr122165652216639E070-32597
chr122178292217920E070-31316
chr122179952218064E070-31172
chr122180882218142E070-31094
chr122182862218412E070-30824
chr122202682220334E070-28902
chr122204792220542E070-28694
chr122206282220834E070-28402
chr122211192221343E070-27893
chr122214062221456E070-27780
chr122234862223537E070-25699
chr122235442223601E070-25635
chr122239592224016E070-25220
chr122240642224132E070-25104
chr122241972224515E070-24721
chr122246552224788E070-24448
chr122248022224878E070-24358
chr122256112225793E070-23443
chr122259272226169E070-23067
chr122266502226853E070-22383
chr122270922227150E070-22086
chr122360882236152E070-13084
chr122427982243602E070-5634
chr122436212247524E070-1712
chr122475452247627E070-1609
chr122476612247721E070-1515
chr122478312248049E070-1187
chr122523772253055E0703141
chr122530932253224E0703857
chr122532622253389E0704026
chr122609412261024E07011705
chr122613772261431E07012141
chr122615582261667E07012322
chr122617012261777E07012465
chr122620222262208E07012786
chr122622702262632E07013034
chr122626802262823E07013444
chr122629222263002E07013686
chr122672932267413E07018057
chr122674342267492E07018198
chr122676052267782E07018369
chr122799782280109E07030742
chr122801882280282E07030952
chr122808222280978E07031586
chr122812472281365E07032011
chr122814692281711E07032233
chr121998882199945E071-49291
chr121999782200018E071-49218
chr122001432200193E071-49043
chr122003312200381E071-48855
chr122006752200796E071-48440
chr122008642200961E071-48275
chr122009732201170E071-48066
chr122015222201576E071-47660
chr122015942201662E071-47574
chr122017092202460E071-46776
chr122026472203176E071-46060
chr122033162203524E071-45712
chr122035332203680E071-45556
chr122038322204147E071-45089
chr122041992204358E071-44878
chr122044102204460E071-44776
chr122045312204581E071-44655
chr122046772204853E071-44383
chr122050172205061E071-44175
chr122054272205499E071-43737
chr122056102205833E071-43403
chr122058652205962E071-43274
chr122060052206162E071-43074
chr122072662207971E071-41265
chr122079762208112E071-41124
chr122081582208369E071-40867
chr122083882208451E071-40785
chr122092772209376E071-39860
chr122095662209823E071-39413
chr122098542210030E071-39206
chr122102172211564E071-37672
chr122115662211663E071-37573
chr122198642220163E071-29073
chr122202682220334E071-28902
chr122204792220542E071-28694
chr122206282220834E071-28402
chr122211192221343E071-27893
chr122214062221456E071-27780
chr122234862223537E071-25699
chr122235442223601E071-25635
chr122239592224016E071-25220
chr122240642224132E071-25104
chr122241972224515E071-24721
chr122246552224788E071-24448
chr122248022224878E071-24358
chr122256112225793E071-23443
chr122259272226169E071-23067
chr122279902228378E071-20858
chr122284992228613E071-20623
chr122292702229320E071-19916
chr122295542229608E071-19628
chr122296262229676E071-19560
chr122297612229917E071-19319
chr122299522230043E071-19193
chr122301102230215E071-19021
chr122303002230372E071-18864
chr122304042233096E071-16140
chr122331172233729E071-15507
chr122338472233970E071-15266
chr122340142234064E071-15172
chr122341162234360E071-14876
chr122349712235053E071-14183
chr122360882236152E071-13084
chr122415532241630E071-7606
chr122418602242158E071-7078
chr122425122242755E071-6481
chr122427982243602E071-5634
chr122436212247524E071-1712
chr122492532249345E07117
chr122498942250065E071658
chr122522262252293E0712990
chr122523772253055E0713141
chr122530932253224E0713857
chr122532622253389E0714026
chr122534552254782E0714219
chr122615582261667E07112322
chr122617012261777E07112465
chr122620222262208E07112786
chr122622702262632E07113034
chr122626802262823E07113444
chr121998882199945E072-49291
chr121999782200018E072-49218
chr122001432200193E072-49043
chr122003312200381E072-48855
chr122006752200796E072-48440
chr122008642200961E072-48275
chr122009732201170E072-48066
chr122015222201576E072-47660
chr122015942201662E072-47574
chr122017092202460E072-46776
chr122026472203176E072-46060
chr122033162203524E072-45712
chr122035332203680E072-45556
chr122038322204147E072-45089
chr122041992204358E072-44878
chr122044102204460E072-44776
chr122045312204581E072-44655
chr122046772204853E072-44383
chr122050172205061E072-44175
chr122054272205499E072-43737
chr122056102205833E072-43403
chr122058652205962E072-43274
chr122060052206162E072-43074
chr122062632206379E072-42857
chr122064422206565E072-42671
chr122066702206796E072-42440
chr122072662207971E072-41265
chr122079762208112E072-41124
chr122092772209376E072-39860
chr122095662209823E072-39413
chr122098542210030E072-39206
chr122102172211564E072-37672
chr122198642220163E072-29073
chr122202682220334E072-28902
chr122204792220542E072-28694
chr122206282220834E072-28402
chr122211192221343E072-27893
chr122214062221456E072-27780
chr122234862223537E072-25699
chr122235442223601E072-25635
chr122239592224016E072-25220
chr122240642224132E072-25104
chr122241972224515E072-24721
chr122246552224788E072-24448
chr122248022224878E072-24358
chr122256112225793E072-23443
chr122259272226169E072-23067
chr122266502226853E072-22383
chr122270922227150E072-22086
chr122272472227389E072-21847
chr122297612229917E072-19319
chr122299522230043E072-19193
chr122301102230215E072-19021
chr122303002230372E072-18864
chr122304042233096E072-16140
chr122331172233729E072-15507
chr122338472233970E072-15266
chr122340142234064E072-15172
chr122341162234360E072-14876
chr122349712235053E072-14183
chr122350732235147E072-14089
chr122354152235489E072-13747
chr122356152235665E072-13571
chr122356902235734E072-13502
chr122360882236152E072-13084
chr122418602242158E072-7078
chr122422042242293E072-6943
chr122423352242421E072-6815
chr122425122242755E072-6481
chr122427982243602E072-5634
chr122436212247524E072-1712
chr122523772253055E0723141
chr122530932253224E0723857
chr122532622253389E0724026
chr122534552254782E0724219
chr121998882199945E073-49291
chr121999782200018E073-49218
chr122001432200193E073-49043
chr122003312200381E073-48855
chr122006752200796E073-48440
chr122008642200961E073-48275
chr122009732201170E073-48066
chr122015222201576E073-47660
chr122015942201662E073-47574
chr122017092202460E073-46776
chr122026472203176E073-46060
chr122033162203524E073-45712
chr122035332203680E073-45556
chr122038322204147E073-45089
chr122041992204358E073-44878
chr122044102204460E073-44776
chr122045312204581E073-44655
chr122046772204853E073-44383
chr122050172205061E073-44175
chr122054272205499E073-43737
chr122056102205833E073-43403
chr122058652205962E073-43274
chr122060052206162E073-43074
chr122062632206379E073-42857
chr122072662207971E073-41265
chr122079762208112E073-41124
chr122081582208369E073-40867
chr122083882208451E073-40785
chr122087552208893E073-40343
chr122092772209376E073-39860
chr122095662209823E073-39413
chr122098542210030E073-39206
chr122102172211564E073-37672
chr122146902214772E073-34464
chr122153002215345E073-33891
chr122155322215590E073-33646
chr122158032215906E073-33330
chr122160152216062E073-33174
chr122162812216331E073-32905
chr122165652216639E073-32597
chr122179952218064E073-31172
chr122180882218142E073-31094
chr122182862218412E073-30824
chr122186372218687E073-30549
chr122198642220163E073-29073
chr122202682220334E073-28902
chr122204792220542E073-28694
chr122206282220834E073-28402
chr122211192221343E073-27893
chr122234862223537E073-25699
chr122235442223601E073-25635
chr122239592224016E073-25220
chr122240642224132E073-25104
chr122241972224515E073-24721
chr122246552224788E073-24448
chr122248022224878E073-24358
chr122256112225793E073-23443
chr122259272226169E073-23067
chr122266502226853E073-22383
chr122270922227150E073-22086
chr122272472227389E073-21847
chr122274322227486E073-21750
chr122278232227967E073-21269
chr122279902228378E073-20858
chr122284992228613E073-20623
chr122286742228745E073-20491
chr122297612229917E073-19319
chr122299522230043E073-19193
chr122301102230215E073-19021
chr122303002230372E073-18864
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