rs2651251

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0168 (5006/29794,GnomAD)
C==0166 (4838/29118,TOPMED)
C==0207 (1037/5008,1000G)
C==0196 (756/3854,ALSPAC)
C==0200 (743/3708,TWINSUK)
chr12:101275238 (GRCh38.p7) (12q23.2)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.101275238C>T
GRCh37.p13 chr 12NC_000012.11:g.101669016C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.047T=0.953
1000GenomesAmericanSub694C=0.260T=0.740
1000GenomesEast AsianSub1008C=0.373T=0.627
1000GenomesEuropeSub1006C=0.206T=0.794
1000GenomesGlobalStudy-wide5008C=0.207T=0.793
1000GenomesSouth AsianSub978C=0.220T=0.780
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.196T=0.804
The Genome Aggregation DatabaseAfricanSub8694C=0.070T=0.930
The Genome Aggregation DatabaseAmericanSub838C=0.280T=0.720
The Genome Aggregation DatabaseEast AsianSub1602C=0.360T=0.640
The Genome Aggregation DatabaseEuropeSub18358C=0.191T=0.808
The Genome Aggregation DatabaseGlobalStudy-wide29794C=0.168T=0.832
The Genome Aggregation DatabaseOtherSub302C=0.250T=0.750
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.166T=0.833
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.200T=0.800
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs26512517.49E-06alcohol dependence (age at onset)24962325

eQTL of rs2651251 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2651251 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12101691390101691641E06722374
chr12101692002101692211E06722986
chr12101692243101692491E06723227
chr12101692002101692211E06922986
chr12101692243101692491E06923227
chr12101684127101684167E07115111
chr12101691390101691641E07122374
chr12101691390101691641E07222374
chr12101692002101692211E07222986
chr12101632145101633097E081-35919
chr12101633155101633205E081-35811
chr12101632145101633097E082-35919
chr12101633155101633205E082-35811






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr12101673164101673326E0674148
chr12101673369101673461E0674353
chr12101673570101674315E0674554
chr12101674460101674520E0675444
chr12101674561101674663E0675545
chr12101692853101693016E06723837
chr12101693076101693399E06724060
chr12101693724101694082E06724708
chr12101673164101673326E0684148
chr12101673369101673461E0684353
chr12101673570101674315E0684554
chr12101674460101674520E0685444
chr12101674561101674663E0685545
chr12101692853101693016E06823837
chr12101693076101693399E06824060
chr12101673164101673326E0694148
chr12101673369101673461E0694353
chr12101673570101674315E0694554
chr12101674460101674520E0695444
chr12101674561101674663E0695545
chr12101692853101693016E06923837
chr12101693076101693399E06924060
chr12101693724101694082E06924708
chr12101673164101673326E0704148
chr12101673369101673461E0704353
chr12101673570101674315E0704554
chr12101674460101674520E0705444
chr12101674561101674663E0705545
chr12101673056101673115E0714040
chr12101673121101673150E0714105
chr12101673164101673326E0714148
chr12101673369101673461E0714353
chr12101673570101674315E0714554
chr12101674460101674520E0715444
chr12101674561101674663E0715545
chr12101692853101693016E07123837
chr12101693076101693399E07124060
chr12101693724101694082E07124708
chr12101673164101673326E0724148
chr12101673369101673461E0724353
chr12101673570101674315E0724554
chr12101674460101674520E0725444
chr12101674561101674663E0725545
chr12101692853101693016E07223837
chr12101693076101693399E07224060
chr12101673164101673326E0734148
chr12101673369101673461E0734353
chr12101673570101674315E0734554
chr12101674460101674520E0735444
chr12101674561101674663E0735545
chr12101673164101673326E0744148
chr12101673369101673461E0744353
chr12101673570101674315E0744554
chr12101674460101674520E0745444
chr12101674561101674663E0745545
chr12101692853101693016E07423837
chr12101693076101693399E07424060
chr12101693724101694082E07424708
chr12101673369101673461E0814353
chr12101673570101674315E0814554
chr12101674460101674520E0815444
chr12101674561101674663E0815545
chr12101673056101673115E0824040
chr12101673121101673150E0824105
chr12101673164101673326E0824148
chr12101673369101673461E0824353
chr12101673570101674315E0824554
chr12101674460101674520E0825444
chr12101674561101674663E0825545