SNP Detail Info-rs2709386

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0347 (10362/29826,GnomAD)
A=0332 (9690/29118,TOPMED)
A=0382 (1915/5008,1000G)
A=0362 (1397/3854,ALSPAC)
A=0372 (1379/3708,TWINSUK)

Position: chr2:207632310 (GRCh38.p7) (2q33.3)

Phenotype: OD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 21 Enhancers around

Promoter: 27 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 2	NC_000002.12:g.207632310G>A
GRCh37.p13 chr 2	NC_000002.11:g.208497034G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.725	A=0.275
1000Genomes	American	Sub	694	G=0.590	A=0.410
1000Genomes	East Asian	Sub	1008	G=0.596	A=0.404
1000Genomes	Europe	Sub	1006	G=0.643	A=0.357
1000Genomes	Global	Study-wide	5008	G=0.618	A=0.382
1000Genomes	South Asian	Sub	978	G=0.490	A=0.510
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.638	A=0.362
The Genome Aggregation Database	African	Sub	8686	G=0.705	A=0.295
The Genome Aggregation Database	American	Sub	832	G=0.570	A=0.430
The Genome Aggregation Database	East Asian	Sub	1604	G=0.597	A=0.403
The Genome Aggregation Database	Europe	Sub	18402	G=0.635	A=0.364
The Genome Aggregation Database	Global	Study-wide	29826	G=0.652	A=0.347
The Genome Aggregation Database	Other	Sub	302	G=0.710	A=0.290
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.667	A=0.332
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.628	A=0.372

PMID	Title	Author	Journal
23183491	Genome-wide association study identifies a potent locus associated with human opioid sensitivity.	Nishizawa D	Mol Psychiatry

SNP ID	p-value	Traits	Study
rs2709386	1.14E-06	Opioid sensitivity	23183491

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr2	208467556	208467656	E067	-29378
chr2	208467955	208468204	E067	-28830
chr2	208468345	208468451	E067	-28583
chr2	208467955	208468204	E068	-28830
chr2	208468345	208468451	E068	-28583
chr2	208467556	208467656	E069	-29378
chr2	208467955	208468204	E069	-28830
chr2	208468345	208468451	E069	-28583
chr2	208528918	208529061	E070	31884
chr2	208530054	208530175	E070	33020
chr2	208530194	208530330	E070	33160
chr2	208468345	208468451	E071	-28583
chr2	208477393	208477872	E071	-19162
chr2	208467556	208467656	E072	-29378
chr2	208467955	208468204	E072	-28830
chr2	208468345	208468451	E072	-28583
chr2	208477393	208477872	E072	-19162
chr2	208482460	208482572	E072	-14462
chr2	208486395	208486519	E073	-10515
chr2	208487298	208487338	E073	-9696
chr2	208491753	208492513	E073	-4521

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr2	208488612	208488838	E067	-8196
chr2	208488906	208491332	E067	-5702
chr2	208488612	208488838	E068	-8196
chr2	208488906	208491332	E068	-5702
chr2	208491433	208491516	E068	-5518
chr2	208491536	208491597	E068	-5437
chr2	208491630	208491681	E068	-5353
chr2	208488612	208488838	E069	-8196
chr2	208488906	208491332	E069	-5702
chr2	208488612	208488838	E070	-8196
chr2	208488906	208491332	E070	-5702
chr2	208488612	208488838	E071	-8196
chr2	208488906	208491332	E071	-5702
chr2	208491433	208491516	E071	-5518
chr2	208491536	208491597	E071	-5437
chr2	208491630	208491681	E071	-5353
chr2	208488612	208488838	E072	-8196
chr2	208488906	208491332	E072	-5702
chr2	208488612	208488838	E073	-8196
chr2	208488906	208491332	E073	-5702
chr2	208488612	208488838	E074	-8196
chr2	208488906	208491332	E074	-5702
chr2	208488906	208491332	E081	-5702
chr2	208488612	208488838	E082	-8196
chr2	208488906	208491332	E082	-5702
chr2	208491433	208491516	E082	-5518
chr2	208491536	208491597	E082	-5437

rs2709386