rs2715689

Homo sapiens
G>T
GUCA1C : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0348 (10154/29118,TOPMED)
G==0300 (1503/5008,1000G)
G==0439 (1691/3854,ALSPAC)
G==0450 (1668/3708,TWINSUK)
chr3:108918583 (GRCh38.p7) (3q13.13)
ND
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.108918583G>T
GRCh37.p13 chr 3NC_000003.11:g.108637430G>T

Gene: GUCA1C, guanylate cyclase activator 1C(minus strand)

Molecule type Change Amino acid[Codon] SO Term
GUCA1C transcriptNM_005459.3:c.N/AIntron Variant
GUCA1C transcript variant X1XM_005247910.3:c.N/AIntron Variant
GUCA1C transcript variant X2XM_011513334.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.203T=0.797
1000GenomesAmericanSub694G=0.400T=0.600
1000GenomesEast AsianSub1008G=0.163T=0.837
1000GenomesEuropeSub1006G=0.432T=0.568
1000GenomesGlobalStudy-wide5008G=0.300T=0.700
1000GenomesSouth AsianSub978G=0.370T=0.630
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.439T=0.561
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.348T=0.651
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.450T=0.550
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs27156894.91E-05alcohol and nictotine co-dependence20158304

eQTL of rs2715689 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2715689 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.