rs2746600

Homo sapiens
A>G
LOC105376617 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0382 (11434/29868,GnomAD)
G=0352 (10259/29118,TOPMED)
G=0429 (2149/5008,1000G)
G=0337 (1297/3854,ALSPAC)
G=0326 (1210/3708,TWINSUK)
chr11:33693095 (GRCh38.p7) (11p13)
AD
GWASdb2
1   publication(s)
See rs on genome
257 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.33693095A>G
GRCh37.p13 chr 11NC_000011.9:g.33714641A>G

Gene: LOC105376617, uncharacterized LOC105376617(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376617 transcript variant X3XR_001748167.1:n.N/AIntron Variant
LOC105376617 transcript variant X6XR_001748171.1:n.N/AIntron Variant
LOC105376617 transcript variant X1XR_931170.2:n.N/AIntron Variant
LOC105376617 transcript variant X3XR_001748168.1:n.N/AGenic Upstream Transcript Variant
LOC105376617 transcript variant X4XR_001748169.1:n.N/AGenic Upstream Transcript Variant
LOC105376617 transcript variant X5XR_001748170.1:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.598G=0.402
1000GenomesAmericanSub694A=0.650G=0.350
1000GenomesEast AsianSub1008A=0.428G=0.572
1000GenomesEuropeSub1006A=0.659G=0.341
1000GenomesGlobalStudy-wide5008A=0.571G=0.429
1000GenomesSouth AsianSub978A=0.530G=0.470
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.663G=0.337
The Genome Aggregation DatabaseAfricanSub8680A=0.622G=0.378
The Genome Aggregation DatabaseAmericanSub838A=0.610G=0.390
The Genome Aggregation DatabaseEast AsianSub1612A=0.403G=0.597
The Genome Aggregation DatabaseEuropeSub18436A=0.633G=0.366
The Genome Aggregation DatabaseGlobalStudy-wide29868A=0.617G=0.382
The Genome Aggregation DatabaseOtherSub302A=0.670G=0.330
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.647G=0.352
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.674G=0.326
PMID Title Author Journal

P-Value

SNP ID p-value Traits Study
rs27466008.29E-05alcoholismpha002893

eQTL of rs2746600 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2746600 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr113367350233674804E067-39837
chr113371032833714858E0670
chr113371662233717158E0671981
chr113372071133724005E0676070
chr113372414933724309E0679508
chr113372433933724435E0679698
chr113372445033724563E0679809
chr113372475233725125E06710111
chr113372532333726625E06710682
chr113372665233727005E06712011
chr113372702533727264E06712384
chr113372735733727417E06712716
chr113372745733727544E06712816
chr113372763133727715E06712990
chr113372790833727977E06713267
chr113372798233728081E06713341
chr113372812333728594E06713482
chr113373744033737513E06722799
chr113373751633737664E06722875
chr113373786333738119E06723222
chr113373819233738277E06723551
chr113373828133738424E06723640
chr113373899833739093E06724357
chr113374273433743684E06728093
chr113374557233747078E06730931
chr113374710333747212E06732462
chr113375215533752215E06737514
chr113375230033752467E06737659
chr113375432933754578E06739688
chr113371032833714858E0680
chr113371605833716146E0681417
chr113371628533716550E0681644
chr113371662233717158E0681981
chr113371716433717432E0682523
chr113372414933724309E0689508
chr113372433933724435E0689698
chr113372445033724563E0689809
chr113372532333726625E06810682
chr113372665233727005E06812011
chr113372702533727264E06812384
chr113372735733727417E06812716
chr113372745733727544E06812816
chr113372763133727715E06812990
chr113372790833727977E06813267
chr113372798233728081E06813341
chr113372812333728594E06813482
chr113372866433728768E06814023
chr113372882333728904E06814182
chr113372893333728973E06814292
chr113372904533729159E06814404
chr113373569333735839E06821052
chr113373819233738277E06823551
chr113373828133738424E06823640
chr113373899833739093E06824357
chr113374273433743684E06828093
chr113374371033745488E06829069
chr113374557233747078E06830931
chr113374710333747212E06832462
chr113375432933754578E06839688
chr113369090933690976E069-23665
chr113371032833714858E0690
chr113371576733715842E0691126
chr113371605833716146E0691417
chr113371628533716550E0691644
chr113371662233717158E0691981
chr113371716433717432E0692523
chr113372475233725125E06910111
chr113372532333726625E06910682
chr113372665233727005E06912011
chr113372702533727264E06912384
chr113372735733727417E06912716
chr113372745733727544E06912816
chr113372763133727715E06912990
chr113372812333728594E06913482
chr113372866433728768E06914023
chr113372882333728904E06914182
chr113372893333728973E06914292
chr113372904533729159E06914404
chr113372920733729297E06914566
chr113372950633729852E06914865
chr113373016633730489E06915525
chr113374273433743684E06928093
chr113374371033745488E06929069
chr113374557233747078E06930931
chr113374710333747212E06932462
chr113375313133753263E06938490
chr113375332533753730E06938684
chr113370462933704863E070-9778
chr113370491433704974E070-9667
chr113370504533705085E070-9556
chr113370536933705424E070-9217
chr113370544533705495E070-9146
chr113370552833705578E070-9063
chr113370569833705814E070-8827
chr113370595233706164E070-8477
chr113371032833714858E0700
chr113371490333715061E070262
chr113371518333715271E070542
chr113371527733715529E070636
chr113371553333715586E070892
chr113371559733715651E070956
chr113371567533715719E0701034
chr113371576733715842E0701126
chr113371605833716146E0701417
chr113371628533716550E0701644
chr113371662233717158E0701981
chr113371716433717432E0702523
chr113371752533717704E0702884
chr113371777733717827E0703136
chr113371789133717952E0703250
chr113371802933718255E0703388
chr113371826733718336E0703626
chr113371835433718471E0703713
chr113371848933718810E0703848
chr113371883833719241E0704197
chr113371952233719566E0704881
chr113372071133724005E0706070
chr113372414933724309E0709508
chr113373410533734254E07019464
chr113373482833735624E07020187
chr113373569333735839E07021052
chr113373744033737513E07022799
chr113373751633737664E07022875
chr113373786333738119E07023222
chr113373819233738277E07023551
chr113373828133738424E07023640
chr113374273433743684E07028093
chr113371032833714858E0710
chr113371490333715061E071262
chr113371518333715271E071542
chr113371628533716550E0711644
chr113371662233717158E0711981
chr113371716433717432E0712523
chr113371848933718810E0713848
chr113371883833719241E0714197
chr113371952233719566E0714881
chr113372071133724005E0716070
chr113372414933724309E0719508
chr113372433933724435E0719698
chr113372445033724563E0719809
chr113372475233725125E07110111
chr113372532333726625E07110682
chr113372665233727005E07112011
chr113372702533727264E07112384
chr113372735733727417E07112716
chr113372745733727544E07112816
chr113372763133727715E07112990
chr113372790833727977E07113267
chr113372798233728081E07113341
chr113372812333728594E07113482
chr113372866433728768E07114023
chr113372882333728904E07114182
chr113372893333728973E07114292
chr113372904533729159E07114404
chr113373751633737664E07122875
chr113373786333738119E07123222
chr113373819233738277E07123551
chr113373828133738424E07123640
chr113373899833739093E07124357
chr113374273433743684E07128093
chr113374371033745488E07129069
chr113374557233747078E07130931
chr113374710333747212E07132462
chr113371032833714858E0720
chr113371605833716146E0721417
chr113371628533716550E0721644
chr113371662233717158E0721981
chr113372475233725125E07210111
chr113372532333726625E07210682
chr113372665233727005E07212011
chr113372702533727264E07212384
chr113372735733727417E07212716
chr113372745733727544E07212816
chr113372763133727715E07212990
chr113372790833727977E07213267
chr113372798233728081E07213341
chr113372812333728594E07213482
chr113373482833735624E07220187
chr113373899833739093E07224357
chr113374557233747078E07230931
chr113374730233747379E07232661
chr113375412633754314E07239485
chr113375432933754578E07239688
chr113367322033673362E073-41279
chr113367339533673460E073-41181
chr113367350233674804E073-39837
chr113371605833716146E0731417
chr113371628533716550E0731644
chr113371662233717158E0731981
chr113371716433717432E0732523
chr113371963633719856E0734995
chr113371987133720301E0735230
chr113372532333726625E07310682
chr113372665233727005E07312011
chr113372702533727264E07312384
chr113372735733727417E07312716
chr113372745733727544E07312816
chr113372763133727715E07312990
chr113373482833735624E07320187
chr113373569333735839E07321052
chr113373744033737513E07322799
chr113374371033745488E07329069
chr113374557233747078E07330931
chr113375215533752215E07337514
chr113375230033752467E07337659
chr113375298633753051E07338345
chr113375313133753263E07338490
chr113375412633754314E07339485
chr113375432933754578E07339688
chr113369067533690837E074-23804
chr113369090933690976E074-23665
chr113369100833691124E074-23517
chr113369129433691389E074-23252
chr113371032833714858E0740
chr113372414933724309E0749508
chr113372433933724435E0749698
chr113372445033724563E0749809
chr113372475233725125E07410111
chr113372532333726625E07410682
chr113372665233727005E07412011
chr113372702533727264E07412384
chr113372735733727417E07412716
chr113372745733727544E07412816
chr113372763133727715E07412990
chr113372790833727977E07413267
chr113372798233728081E07413341
chr113372812333728594E07413482
chr113372866433728768E07414023
chr113373705633737406E07422415
chr113373744033737513E07422799
chr113373751633737664E07422875
chr113374229133742441E07427650
chr113374246833742625E07427827
chr113374273433743684E07428093
chr113374371033745488E07429069
chr113374557233747078E07430931
chr113374710333747212E07432462
chr113367350233674804E081-39837
chr113371032833714858E0810
chr113371553333715586E081892
chr113371559733715651E081956
chr113371567533715719E0811034
chr113371576733715842E0811126
chr113371605833716146E0811417
chr113371628533716550E0811644
chr113371662233717158E0811981
chr113371716433717432E0812523
chr113371752533717704E0812884
chr113372071133724005E0816070
chr113374273433743684E08128093
chr113375194633751999E08137305
chr113375215533752215E08137514
chr113375230033752467E08137659
chr113371490333715061E082262
chr113371628533716550E0821644
chr113371662233717158E0821981
chr113371716433717432E0822523










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr113375599933759411E06741358
chr113375599933759411E06841358
chr113375599933759411E06941358
chr113375599933759411E07041358
chr113375599933759411E07141358
chr113375599933759411E07241358
chr113375599933759411E07341358
chr113375599933759411E07441358
chr113375599933759411E08141358
chr113375599933759411E08241358