rs277778

Homo sapiens
A>G
LOC105375642 : Intron Variant
LOC107986956 : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0223 (6683/29960,GnomAD)
A==0229 (6684/29118,TOPMED)
A==0232 (1160/5008,1000G)
A==0250 (965/3854,ALSPAC)
A==0259 (961/3708,TWINSUK)
chr8:93340574 (GRCh38.p7) (8q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.93340574A>G
GRCh37.p13 chr 8NC_000008.10:g.94352802A>G

Gene: LOC105375642, uncharacterized LOC105375642(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105375642 transcript variant X1XR_001745998.1:n.N/AIntron Variant
LOC105375642 transcript variant X2XR_001745999.1:n.N/AIntron Variant
LOC105375642 transcript variant X3XR_001746000.1:n.N/AIntron Variant
LOC105375642 transcript variant X4XR_001746001.1:n.N/AIntron Variant
LOC105375642 transcript variant X5XR_001746002.1:n.N/AIntron Variant

Gene: LOC107986956, uncharacterized LOC107986956(minus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
LOC107986956 transcript variant X1XR_001745995.1:n.N/AUpstream Transcript Variant
LOC107986956 transcript variant X2XR_001745996.1:n.N/AUpstream Transcript Variant
LOC107986956 transcript variant X3XR_001745997.1:n.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.200G=0.800
1000GenomesAmericanSub694A=0.240G=0.760
1000GenomesEast AsianSub1008A=0.214G=0.786
1000GenomesEuropeSub1006A=0.258G=0.742
1000GenomesGlobalStudy-wide5008A=0.232G=0.768
1000GenomesSouth AsianSub978A=0.260G=0.740
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.250G=0.750
The Genome Aggregation DatabaseAfricanSub8726A=0.210G=0.790
The Genome Aggregation DatabaseAmericanSub838A=0.320G=0.680
The Genome Aggregation DatabaseEast AsianSub1618A=0.182G=0.818
The Genome Aggregation DatabaseEuropeSub18476A=0.226G=0.773
The Genome Aggregation DatabaseGlobalStudy-wide29960A=0.223G=0.776
The Genome Aggregation DatabaseOtherSub302A=0.350G=0.650
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.229G=0.770
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.259G=0.741
PMID Title Author Journal
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs2777784.31E-05alcohol dependence19581569

eQTL of rs277778 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs277778 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr89437198994372046E06719187
chr89437208494372138E06719282
chr89437234894372398E06719546
chr89437255194373060E06719749
chr89437316694373764E06720364
chr89437316694373764E06820364
chr89437154894371876E06918746
chr89437187994371923E06919077
chr89437198994372046E06919187
chr89437071294370816E07017910
chr89437094994370999E07018147
chr89437101594371292E07018213
chr89437132194371504E07018519
chr89437154894371876E07018746
chr89437187994371923E07019077
chr89437198994372046E07019187
chr89437208494372138E07019282
chr89437234894372398E07019546
chr89437255194373060E07019749
chr89437316694373764E07020364
chr89437379494374026E07020992
chr89437402994374178E07021227
chr89437420494374276E07021402
chr89437439494374467E07021592
chr89437455494374770E07021752
chr89437502494375094E07022222
chr89437532394375439E07022521
chr89437703794377114E07024235
chr89437716594377230E07024363
chr89437723294377423E07024430
chr89437765294377763E07024850
chr89437786094377915E07025058
chr89437813394378183E07025331
chr89437914694379350E07026344
chr89440134494401439E07048542
chr89440228094402351E07049478
chr89440235294402440E07049550
chr89436374294364020E07110940
chr89437234894372398E07219546
chr89437316694373764E07220364
chr89437101594371292E07318213
chr89437132194371504E07318519
chr89437154894371876E07318746
chr89437187994371923E07319077
chr89437198994372046E07319187
chr89437208494372138E07319282
chr89437234894372398E07319546
chr89437255194373060E07319749
chr89437316694373764E07320364
chr89437071294370816E07417910
chr89437094994370999E07418147
chr89437101594371292E07418213
chr89437132194371504E07418519
chr89437154894371876E07418746
chr89437187994371923E07419077
chr89437198994372046E07419187
chr89437208494372138E07419282
chr89437234894372398E07419546
chr89430903794309153E081-43649
chr89430927194309526E081-43276
chr89430960194309844E081-42958
chr89430985094309943E081-42859
chr89431002094310149E081-42653
chr89431015094310190E081-42612
chr89431033394310433E081-42369
chr89431050494310595E081-42207
chr89437071294370816E08117910
chr89437094994370999E08118147
chr89437101594371292E08118213
chr89437132194371504E08118519
chr89437154894371876E08118746
chr89437187994371923E08119077
chr89437198994372046E08119187
chr89437208494372138E08119282
chr89437234894372398E08119546
chr89437255194373060E08119749
chr89437316694373764E08120364
chr89437379494374026E08120992
chr89437402994374178E08121227
chr89437703794377114E08124235
chr89437716594377230E08124363
chr89437723294377423E08124430
chr89437765294377763E08124850
chr89437071294370816E08217910