rs2822589

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0478 (14264/29838,GnomAD)
T==0447 (13026/29118,TOPMED)
T==0423 (2120/5008,1000G)
C=0371 (1430/3854,ALSPAC)
C=0377 (1399/3708,TWINSUK)
chr21:14339219 (GRCh38.p7) (21q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
7 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 21NC_000021.9:g.14339219T>C
GRCh37.p13 chr 21NC_000021.8:g.15711540T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.220C=0.780
1000GenomesAmericanSub694T=0.630C=0.370
1000GenomesEast AsianSub1008T=0.317C=0.683
1000GenomesEuropeSub1006T=0.620C=0.380
1000GenomesGlobalStudy-wide5008T=0.423C=0.577
1000GenomesSouth AsianSub978T=0.460C=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.629C=0.371
The Genome Aggregation DatabaseAfricanSub8680T=0.279C=0.721
The Genome Aggregation DatabaseAmericanSub834T=0.660C=0.340
The Genome Aggregation DatabaseEast AsianSub1612T=0.337C=0.663
The Genome Aggregation DatabaseEuropeSub18410T=0.645C=0.354
The Genome Aggregation DatabaseGlobalStudy-wide29838T=0.522C=0.478
The Genome Aggregation DatabaseOtherSub302T=0.550C=0.450
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.447C=0.552
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.623C=0.377
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs28225890.00085alcohol dependence20201924

eQTL of rs2822589 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2822589 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr211575326415753417E06941724
chr211575358415753659E06942044
chr211575326415753417E07141724
chr211575358415753659E07142044
chr211575326415753417E07241724
chr211575326415753417E07441724
chr211575358415753659E07442044




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr211575451715756862E06742977
chr211575451715756862E06842977
chr211575451715756862E06942977
chr211575451715756862E07042977
chr211575451715756862E07142977
chr211575451715756862E07242977
chr211575451715756862E07342977
chr211575451715756862E07442977
chr211575451715756862E08142977
chr211575451715756862E08242977