rs2826659

Homo sapiens
A>C / A>T
NCAM2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0158 (4741/29966,GnomAD)
C=0126 (3670/29118,TOPMED)
C=0100 (500/5008,1000G)
chr21:21115536 (GRCh38.p7) (21q21.1)
AD
GWASdb2 | GWASCatalog
1   publication(s)
See rs on genome
183 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 21NC_000021.9:g.21115536A>C
GRCh38.p7 chr 21NC_000021.9:g.21115536A>T
GRCh37.p13 chr 21NC_000021.8:g.22487854A>C
GRCh37.p13 chr 21NC_000021.8:g.22487854A>T

Gene: NCAM2, neural cell adhesion molecule 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
NCAM2 transcriptNM_004540.3:c.N/AIntron Variant
NCAM2 transcript variant X2XM_011529576.2:c.N/AIntron Variant
NCAM2 transcript variant X4XM_011529579.2:c.N/AIntron Variant
NCAM2 transcript variant X3XM_017028353.1:c.N/AIntron Variant
NCAM2 transcript variant X7XM_017028354.1:c.N/AIntron Variant
NCAM2 transcript variant X9XM_017028355.1:c.N/AIntron Variant
NCAM2 transcript variant X10XM_017028356.1:c.N/AIntron Variant
NCAM2 transcript variant X12XM_017028357.1:c.N/AIntron Variant
NCAM2 transcript variant X1XM_011529575.2:c.N/AGenic Upstream Transcript Variant
NCAM2 transcript variant X5XM_011529580.2:c.N/AGenic Upstream Transcript Variant
NCAM2 transcript variant X6XM_011529581.2:c.N/AGenic Upstream Transcript Variant
NCAM2 transcript variant X8XM_011529582.2:c.N/AGenic Upstream Transcript Variant
NCAM2 transcript variant X11XM_011529585.2:c.N/AGenic Upstream Transcript Variant
NCAM2 transcript variant X13XM_017028358.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.984C=0.016
1000GenomesAmericanSub694A=0.860C=0.140
1000GenomesEast AsianSub1008A=0.991C=0.009
1000GenomesEuropeSub1006A=0.759C=0.241
1000GenomesGlobalStudy-wide5008A=0.900C=0.100
1000GenomesSouth AsianSub978A=0.870C=0.130
The Genome Aggregation DatabaseAfricanSub8722A=0.954C=0.046
The Genome Aggregation DatabaseAmericanSub838A=0.870C=0.130
The Genome Aggregation DatabaseEast AsianSub1622A=0.993C=0.007
The Genome Aggregation DatabaseEuropeSub18482A=0.775C=0.224
The Genome Aggregation DatabaseGlobalStudy-wide29966A=0.841C=0.158
The Genome Aggregation DatabaseOtherSub302A=0.760C=0.240
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.874C=0.126
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs28266597E-06alcohol dependence (age at onset)24962325

eQTL of rs2826659 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2826659 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr214446447944466911E067-2120
chr214448305744483763E06714026
chr214448381044483885E06714779
chr214448408244484147E06715051
chr214448422344484273E06715192
chr214448428744484350E06715256
chr214448546244485534E06716431
chr214448565544485797E06716624
chr214448589944485949E06716868
chr214442106244421815E068-47216
chr214448381044483885E06814779
chr214448408244484147E06815051
chr214448442444485225E06815393
chr214448525244485302E06816221
chr214448537744485437E06816346
chr214448546244485534E06816431
chr214448565544485797E06816624
chr214442106244421815E069-47216
chr214444806644448881E069-20150
chr214444912744449167E069-19864
chr214446447944466911E069-2120
chr214448207944482325E06913048
chr214448252244482572E06913491
chr214448257844482680E06913547
chr214448305744483763E06914026
chr214448381044483885E06914779
chr214448442444485225E06915393
chr214448525244485302E06916221
chr214448537744485437E06916346
chr214448546244485534E06916431
chr214448565544485797E06916624
chr214448589944485949E06916868
chr214448597144486231E06916940
chr214442106244421815E070-47216
chr214442106244421815E071-47216
chr214444806644448881E071-20150
chr214446447944466911E071-2120
chr214448305744483763E07114026
chr214448381044483885E07114779
chr214448525244485302E07116221
chr214448537744485437E07116346
chr214448546244485534E07116431
chr214448565544485797E07116624
chr214448589944485949E07116868
chr214448597144486231E07116940
chr214448636444486458E07117333
chr214448657644486687E07117545
chr214448881244488862E07119781
chr214448888644489057E07119855
chr214448929244489480E07120261
chr214448955044489658E07120519
chr214442106244421815E072-47216
chr214444806644448881E072-20150
chr214444912744449167E072-19864
chr214446447944466911E072-2120
chr214448305744483763E07214026
chr214448381044483885E07214779
chr214448408244484147E07215051
chr214448422344484273E07215192
chr214448428744484350E07215256
chr214448442444485225E07215393
chr214448537744485437E07216346
chr214448546244485534E07216431
chr214448565544485797E07216624
chr214448589944485949E07216868
chr214448597144486231E07216940
chr214448636444486458E07217333
chr214448888644489057E07219855
chr214448929244489480E07220261
chr214448955044489658E07220519
chr214450673644506968E07237705
chr214442026544420414E073-48617
chr214442052644420644E073-48387
chr214442106244421815E073-47216
chr214446447944466911E073-2120
chr214448381044483885E07314779
chr214448408244484147E07315051
chr214448422344484273E07315192
chr214448428744484350E07315256
chr214448442444485225E07315393
chr214448525244485302E07316221
chr214448537744485437E07316346
chr214448546244485534E07316431
chr214448565544485797E07316624
chr214448589944485949E07316868
chr214448597144486231E07316940
chr214442106244421815E074-47216
chr214446447944466911E074-2120
chr214448381044483885E07414779
chr214448408244484147E07415051
chr214448422344484273E07415192
chr214448428744484350E07415256
chr214448442444485225E07415393
chr214448525244485302E07416221
chr214448537744485437E07416346
chr214448546244485534E07416431
chr214448565544485797E07416624
chr214448589944485949E07416868
chr214448597144486231E07416940
chr214448888644489057E07419855
chr214448929244489480E07420261
chr214448955044489658E07420519
chr214448980144489945E07420770
chr214448994744490112E07420916
chr214442106244421815E081-47216
chr214445697344457511E081-11520
chr214445851244458645E081-10386
chr214445867244458776E081-10255
chr214445885544458944E081-10087
chr214445931044459416E081-9615
chr214445949344459543E081-9488
chr214445957044459650E081-9381
chr214446046044460601E081-8430
chr214446073144460845E081-8186
chr214446109644461146E081-7885
chr214446120944461947E081-7084
chr214446194944462488E081-6543
chr214446253644462586E081-6445
chr214446282044463294E081-5737
chr214446341144464028E081-5003
chr214446447944466911E081-2120
chr214447578944475932E0816758
chr214447624444476468E0817213
chr214448305744483763E08114026
chr214448381044483885E08114779
chr214448408244484147E08115051
chr214448422344484273E08115192
chr214448428744484350E08115256
chr214448442444485225E08115393
chr214448525244485302E08116221
chr214448537744485437E08116346
chr214448546244485534E08116431
chr214448565544485797E08116624
chr214448589944485949E08116868
chr214448597144486231E08116940
chr214448636444486458E08117333
chr214448657644486687E08117545
chr214448669644486767E08117665
chr214448688244486994E08117851
chr214448709144487161E08118060
chr214448726044487320E08118229
chr214448735144487533E08118320
chr214448759444487645E08118563
chr214448929244489480E08120261
chr214448955044489658E08120519
chr214448980144489945E08120770
chr214448994744490112E08120916
chr214449019944490266E08121168
chr214449029844490427E08121267
chr214449061744490682E08121586
chr214449112244491417E08122091
chr214449150644491560E08122475
chr214449176644491810E08122735
chr214449192544491998E08122894
chr214449202444492129E08122993
chr214449233944492446E08123308
chr214449251344492567E08123482
chr214445760744457657E082-11374
chr214445774344457813E082-11218
chr214445786244458216E082-10815
chr214445824944458331E082-10700
chr214446046044460601E082-8430
chr214446073144460845E082-8186
chr214446109644461146E082-7885
chr214446120944461947E082-7084
chr214446194944462488E082-6543
chr214446253644462586E082-6445
chr214446282044463294E082-5737
chr214446341144464028E082-5003
chr214446447944466911E082-2120
chr214448305744483763E08214026
chr214448381044483885E08214779
chr214448408244484147E08215051
chr214448422344484273E08215192
chr214448428744484350E08215256
chr214448442444485225E08215393
chr214448525244485302E08216221
chr214448537744485437E08216346
chr214448546244485534E08216431
chr214448929244489480E08220261
chr214448955044489658E08220519
chr214448980144489945E08220770
chr214448994744490112E08220916










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr214449433744497475E06725306
chr214449433744497475E06825306
chr214449433744497475E06925306
chr214449420044494250E07025169
chr214449433744497475E07025306
chr214449433744497475E07125306
chr214449433744497475E07225306
chr214449433744497475E07325306
chr214449433744497475E07425306
chr214449420044494250E08225169
chr214449433744497475E08225306