SNP Detail Info-rs2827634

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0343 (10264/29902,GnomAD)
G==0382 (11130/29118,TOPMED)
G==0323 (1616/5008,1000G)
G==0327 (1260/3854,ALSPAC)
G==0318 (1178/3708,TWINSUK)

Position: chr21:22603487 (GRCh38.p7) (21q21.2)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 1 Enhancer around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 21	NC_000021.9:g.22603487G>A
GRCh37.p13 chr 21	NC_000021.8:g.23975806G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.528	A=0.472
1000Genomes	American	Sub	694	G=0.280	A=0.720
1000Genomes	East Asian	Sub	1008	G=0.197	A=0.803
1000Genomes	Europe	Sub	1006	G=0.287	A=0.713
1000Genomes	Global	Study-wide	5008	G=0.323	A=0.677
1000Genomes	South Asian	Sub	978	G=0.240	A=0.760
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.327	A=0.673
The Genome Aggregation Database	African	Sub	8708	G=0.492	A=0.508
The Genome Aggregation Database	American	Sub	830	G=0.260	A=0.740
The Genome Aggregation Database	East Asian	Sub	1612	G=0.194	A=0.806
The Genome Aggregation Database	Europe	Sub	18450	G=0.290	A=0.709
The Genome Aggregation Database	Global	Study-wide	29902	G=0.343	A=0.656
The Genome Aggregation Database	Other	Sub	302	G=0.270	A=0.730
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.382	A=0.617
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.318	A=0.682

PMID	Title	Author	Journal
24277619	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	Quillen EE	Am J Med Genet B Neuropsychiatr Genet

SNP ID	p-value	Traits	Study
rs2827634	0.000593	alcohol dependence	24277619

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

rs2827634