rs2828434

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0229 (6877/29936,GnomAD)
T=0192 (5605/29118,TOPMED)
T=0145 (728/5008,1000G)
T=0316 (1217/3854,ALSPAC)
T=0338 (1252/3708,TWINSUK)
chr21:23697122 (GRCh38.p7) (21q21.2)
ND
GWASdb2
1   publication(s)
See rs on genome
5 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 21NC_000021.9:g.23697122G>T
GRCh37.p13 chr 21NC_000021.8:g.25069439G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.987T=0.013
1000GenomesAmericanSub694G=0.840T=0.160
1000GenomesEast AsianSub1008G=0.926T=0.074
1000GenomesEuropeSub1006G=0.651T=0.349
1000GenomesGlobalStudy-wide5008G=0.855T=0.145
1000GenomesSouth AsianSub978G=0.830T=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.684T=0.316
The Genome Aggregation DatabaseAfricanSub8722G=0.940T=0.060
The Genome Aggregation DatabaseAmericanSub836G=0.850T=0.150
The Genome Aggregation DatabaseEast AsianSub1616G=0.938T=0.062
The Genome Aggregation DatabaseEuropeSub18460G=0.671T=0.328
The Genome Aggregation DatabaseGlobalStudy-wide29936G=0.770T=0.229
The Genome Aggregation DatabaseOtherSub302G=0.750T=0.250
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.807T=0.192
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.662T=0.338
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs28284341.33E-05alcohol and nictotine co-dependence20158304

eQTL of rs2828434 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2828434 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr212504986625049996E070-19443
chr212506686125067213E070-2226
chr212506787225068001E081-1438
chr212506686125067213E082-2226
chr212506787225068001E082-1438