rs28390260

Homo sapiens
A>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0343 (10277/29912,GnomAD)
T=0360 (10510/29118,TOPMED)
T=0397 (1990/5008,1000G)
T=0332 (1278/3854,ALSPAC)
T=0320 (1187/3708,TWINSUK)
chr8:81856940 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
89 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81856940A>T
GRCh37.p13 chr 8NC_000008.10:g.82769175A>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.624T=0.376
1000GenomesAmericanSub694A=0.610T=0.390
1000GenomesEast AsianSub1008A=0.403T=0.597
1000GenomesEuropeSub1006A=0.670T=0.330
1000GenomesGlobalStudy-wide5008A=0.603T=0.397
1000GenomesSouth AsianSub978A=0.710T=0.290
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.668T=0.332
The Genome Aggregation DatabaseAfricanSub8702A=0.631T=0.369
The Genome Aggregation DatabaseAmericanSub838A=0.680T=0.320
The Genome Aggregation DatabaseEast AsianSub1614A=0.369T=0.631
The Genome Aggregation DatabaseEuropeSub18456A=0.692T=0.307
The Genome Aggregation DatabaseGlobalStudy-wide29912A=0.656T=0.343
The Genome Aggregation DatabaseOtherSub302A=0.640T=0.360
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.639T=0.360
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.680T=0.320
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs283902603.51E-05alcohol consumption23743675

eQTL of rs28390260 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs28390260 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06517534262573783.1637e-27
cg27398817chr8:82754497SNX160.03852822885839792.3505e-15
cg23324259chr8:82754387SNX160.01757654014848268.0833e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E067-42131
chr88272708482727145E067-42030
chr88272739782727713E067-41462
chr88275141582751459E067-17716
chr88275155182751632E067-17543
chr88275169382751743E067-17432
chr88275176982751905E067-17270
chr88275192082751978E067-17197
chr88275205182752101E067-17074
chr88275213682752286E067-16889
chr88275242482752500E067-16675
chr88275252382752586E067-16589
chr88274913582749745E068-19430
chr88275040382750493E068-18682
chr88275055782750622E068-18553
chr88275073382750913E068-18262
chr88275118682751259E068-17916
chr88275141582751459E068-17716
chr88275155182751632E068-17543
chr88275169382751743E068-17432
chr88275242482752500E068-16675
chr88275252382752586E068-16589
chr88275264882752702E068-16473
chr88275205182752101E069-17074
chr88275213682752286E069-16889
chr88275242482752500E069-16675
chr88275252382752586E069-16589
chr88275264882752702E069-16473
chr88273635982736422E070-32753
chr88273760682737656E070-31519
chr88273770482737783E070-31392
chr88274913582749745E070-19430
chr88272692182727044E071-42131
chr88272739782727713E071-41462
chr88275040382750493E071-18682
chr88275055782750622E071-18553
chr88275073382750913E071-18262
chr88275176982751905E071-17270
chr88275192082751978E071-17197
chr88275205182752101E071-17074
chr88275213682752286E071-16889
chr88275242482752500E071-16675
chr88275252382752586E071-16589
chr88275264882752702E071-16473
chr88277068982771569E0711514
chr88278429982784817E07115124
chr88272629482726439E072-42736
chr88272692182727044E072-42131
chr88272708482727145E072-42030
chr88272739782727713E072-41462
chr88272739782727713E073-41462
chr88272692182727044E074-42131
chr88275040382750493E074-18682
chr88275055782750622E074-18553
chr88275073382750913E074-18262
chr88275118682751259E074-17916
chr88275141582751459E074-17716
chr88275155182751632E074-17543
chr88275169382751743E074-17432
chr88275176982751905E074-17270
chr88275192082751978E074-17197
chr88275205182752101E074-17074
chr88275213682752286E074-16889
chr88275242482752500E074-16675
chr88275252382752586E074-16589
chr88275264882752702E074-16473
chr88278429982784817E07415124
chr88274894182748991E081-20184
chr88275118682751259E081-17916
chr88275141582751459E081-17716
chr88275155182751632E081-17543
chr88275169382751743E081-17432
chr88275176982751905E081-17270
chr88275192082751978E081-17197
chr88275205182752101E081-17074
chr88275213682752286E081-16889
chr88275242482752500E081-16675
chr88275252382752586E081-16589
chr88275264882752702E081-16473
chr88274913582749745E082-19430
chr88274982582749873E082-19302
chr88275155182751632E082-17543
chr88275169382751743E082-17432
chr88275176982751905E082-17270
chr88275192082751978E082-17197
chr88275205182752101E082-17074
chr88275213682752286E082-16889
chr88275242482752500E082-16675
chr88275252382752586E082-16589










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E067-16106
chr88275314082753307E067-15868
chr88275349982753591E067-15584
chr88275360282754599E067-14576
chr88275349982753591E068-15584
chr88275360282754599E068-14576
chr88275461982755486E068-13689
chr88275290282753069E069-16106
chr88275314082753307E069-15868
chr88275349982753591E069-15584
chr88275360282754599E069-14576
chr88275290282753069E070-16106
chr88275314082753307E070-15868
chr88275349982753591E070-15584
chr88275360282754599E070-14576
chr88275290282753069E071-16106
chr88275314082753307E071-15868
chr88275349982753591E071-15584
chr88275360282754599E071-14576
chr88275461982755486E071-13689
chr88275290282753069E072-16106
chr88275314082753307E072-15868
chr88275349982753591E072-15584
chr88275360282754599E072-14576
chr88275290282753069E073-16106
chr88275314082753307E073-15868
chr88275349982753591E073-15584
chr88275360282754599E073-14576
chr88275461982755486E073-13689
chr88275314082753307E074-15868
chr88275349982753591E074-15584
chr88275360282754599E074-14576
chr88275461982755486E074-13689
chr88275360282754599E081-14576
chr88275290282753069E082-16106
chr88275314082753307E082-15868
chr88275349982753591E082-15584
chr88275360282754599E082-14576
chr88275461982755486E082-13689