rs2841269

Homo sapiens
G>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0433 (12960/29922,GnomAD)
C=0374 (10908/29118,TOPMED)
C=0412 (2065/5008,1000G)
C=0456 (1758/3854,ALSPAC)
C=0454 (1682/3708,TWINSUK)
chr14:104919812 (GRCh38.p7) (14q32.33)
AD
GWASdb2
1   publication(s)
See rs on genome
20 Enhancers around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.104919812G>C
GRCh37.p13 chr 14NC_000014.8:g.105386149G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.779C=0.221
1000GenomesAmericanSub694G=0.520C=0.480
1000GenomesEast AsianSub1008G=0.392C=0.608
1000GenomesEuropeSub1006G=0.536C=0.464
1000GenomesGlobalStudy-wide5008G=0.588C=0.412
1000GenomesSouth AsianSub978G=0.630C=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.544C=0.456
The Genome Aggregation DatabaseAfricanSub8708G=0.751C=0.249
The Genome Aggregation DatabaseAmericanSub836G=0.520C=0.480
The Genome Aggregation DatabaseEast AsianSub1612G=0.431C=0.569
The Genome Aggregation DatabaseEuropeSub18464G=0.491C=0.508
The Genome Aggregation DatabaseGlobalStudy-wide29922G=0.566C=0.433
The Genome Aggregation DatabaseOtherSub302G=0.710C=0.290
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.625C=0.374
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.546C=0.454
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs28412690.000369alcohol dependence21314694

eQTL of rs2841269 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr14:105386149C14orf79ENSG00000140104.9G>C2.1602e-15-65963Cerebellum
Chr14:105386149C14orf79ENSG00000140104.9G>C2.6561e-14-65963Frontal_Cortex_BA9
Chr14:105386149C14orf79ENSG00000140104.9G>C4.7616e-17-65963Cortex
Chr14:105386149C14orf79ENSG00000140104.9G>C6.9357e-18-65963Caudate_basal_ganglia

meQTL of rs2841269 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr14105433495105435865E06847346
chr14105362072105362574E070-23575
chr14105362595105363330E070-22819
chr14105394020105394079E0717871
chr14105394143105394224E0717994
chr14105432809105432863E07146660
chr14105433005105433073E07146856
chr14105338199105338546E072-47603
chr14105338607105338700E072-47449
chr14105347135105347191E072-38958
chr14105394228105394338E0728079
chr14105433495105435865E07247346
chr14105338199105338546E073-47603
chr14105338810105339689E073-46460
chr14105347135105347191E073-38958
chr14105433495105435865E07347346
chr14105405819105405899E07419670
chr14105406110105406243E07419961
chr14105406357105406412E07420208
chr14105406557105406645E07420408






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr14105398766105398816E06712617
chr14105398829105400089E06712680
chr14105400148105400822E06713999
chr14105398766105398816E06812617
chr14105398829105400089E06812680
chr14105398829105400089E06912680
chr14105400148105400822E07013999
chr14105398766105398816E07112617
chr14105398829105400089E07112680
chr14105398829105400089E07212680
chr14105398766105398816E07312617
chr14105398829105400089E07312680
chr14105398829105400089E08212680