rs28460675

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0147 (4417/29920,GnomAD)
T=0169 (4922/29114,TOPMED)
T=0170 (850/5008,1000G)
T=0122 (470/3854,ALSPAC)
T=0120 (444/3708,TWINSUK)
chr22:49938357 (GRCh38.p7) (22q13.33)
ND
GWASdb2
1   publication(s)
See rs on genome
80 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.49938357G>T
GRCh37.p13 chr 22NC_000022.10:g.50332005G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.744T=0.256
1000GenomesAmericanSub694G=0.920T=0.080
1000GenomesEast AsianSub1008G=0.948T=0.052
1000GenomesEuropeSub1006G=0.892T=0.108
1000GenomesGlobalStudy-wide5008G=0.830T=0.170
1000GenomesSouth AsianSub978G=0.700T=0.300
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.878T=0.122
The Genome Aggregation DatabaseAfricanSub8704G=0.760T=0.240
The Genome Aggregation DatabaseAmericanSub838G=0.920T=0.080
The Genome Aggregation DatabaseEast AsianSub1620G=0.949T=0.051
The Genome Aggregation DatabaseEuropeSub18456G=0.884T=0.115
The Genome Aggregation DatabaseGlobalStudy-wide29920G=0.852T=0.147
The Genome Aggregation DatabaseOtherSub302G=0.850T=0.150
Trans-Omics for Precision MedicineGlobalStudy-wide29114G=0.830T=0.169
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.880T=0.120
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs284606759.97E-05nicotine dependence (smoking)22377092

eQTL of rs28460675 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs28460675 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr225031049850310654E067-21351
chr225031066450310798E067-21207
chr225032316950324139E067-7866
chr225032415650325119E067-6886
chr225033224250332511E067237
chr225035771050364796E06725705
chr225032415650325119E068-6886
chr225032669250332219E0680
chr225033224250332511E068237
chr225033321750333380E0681212
chr225031049850310654E069-21351
chr225031066450310798E069-21207
chr225032316950324139E069-7866
chr225032415650325119E069-6886
chr225032515050325956E069-6049
chr225032669250332219E0690
chr225033224250332511E069237
chr225033259450332720E069589
chr225033272350332794E069718
chr225033285250332917E069847
chr225033321750333380E0691212
chr225035771050364796E06925705
chr225031039550310445E070-21560
chr225032669250332219E0700
chr225034027450341177E0708269
chr225034120650341515E0709201
chr225034155450341703E0709549
chr225034403850345628E07012033
chr225031039550310445E071-21560
chr225031049850310654E071-21351
chr225031066450310798E071-21207
chr225032316950324139E071-7866
chr225032415650325119E071-6886
chr225032515050325956E071-6049
chr225033224250332511E071237
chr225033259450332720E071589
chr225033272350332794E071718
chr225035771050364796E07125705
chr225028332150283381E072-48624
chr225029490650295021E072-36984
chr225029506850295367E072-36638
chr225031049850310654E072-21351
chr225031066450310798E072-21207
chr225032316950324139E072-7866
chr225032415650325119E072-6886
chr225032669250332219E0720
chr225033224250332511E072237
chr225033259450332720E072589
chr225035771050364796E07225705
chr225029490650295021E073-36984
chr225029506850295367E073-36638
chr225032316950324139E073-7866
chr225032415650325119E073-6886
chr225032669250332219E0730
chr225033224250332511E073237
chr225033321750333380E0731212
chr225035771050364796E07325705
chr225032316950324139E074-7866
chr225032415650325119E074-6886
chr225032515050325956E074-6049
chr225032669250332219E0740
chr225033224250332511E074237
chr225033259450332720E074589
chr225033272350332794E074718
chr225035771050364796E07425705
chr225028593650286009E081-45996
chr225028602750286178E081-45827
chr225028627050286376E081-45629
chr225028687050286927E081-45078
chr225031039550310445E081-21560
chr225031049850310654E081-21351
chr225031066450310798E081-21207
chr225032271950322794E081-9211
chr225032280650323140E081-8865
chr225032316950324139E081-7866
chr225032669250332219E0810
chr225031022550310275E082-21730
chr225031031850310385E082-21620
chr225031039550310445E082-21560
chr225033321750333380E0821212










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr225031116450313510E067-18495
chr225035261250357694E06720607
chr225031116450313510E068-18495
chr225035261250357694E06820607
chr225031116450313510E069-18495
chr225035261250357694E06920607
chr225031116450313510E070-18495
chr225035261250357694E07020607
chr225031116450313510E071-18495
chr225035261250357694E07120607
chr225031116450313510E072-18495
chr225035261250357694E07220607
chr225031116450313510E073-18495
chr225035261250357694E07320607
chr225031116450313510E074-18495
chr225035261250357694E07420607
chr225031116450313510E082-18495
chr225035261250357694E08220607