rs2891786

Homo sapiens
C>T
LHFPL3-AS2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0120 (3614/29966,GnomAD)
T=0115 (3376/29118,TOPMED)
T=0186 (930/5008,1000G)
T=0079 (304/3854,ALSPAC)
T=0074 (275/3708,TWINSUK)
chr7:104918492 (GRCh38.p7) (7q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
81 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.104918492C>T
GRCh37.p13 chr 7NC_000007.13:g.104558939C>T

Gene: LHFPL3-AS2, LHFPL3 antisense RNA 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LHFPL3-AS2 transcriptNR_027374.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.851T=0.149
1000GenomesAmericanSub694C=0.830T=0.170
1000GenomesEast AsianSub1008C=0.619T=0.381
1000GenomesEuropeSub1006C=0.913T=0.087
1000GenomesGlobalStudy-wide5008C=0.814T=0.186
1000GenomesSouth AsianSub978C=0.850T=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.921T=0.079
The Genome Aggregation DatabaseAfricanSub8718C=0.849T=0.151
The Genome Aggregation DatabaseAmericanSub838C=0.860T=0.140
The Genome Aggregation DatabaseEast AsianSub1616C=0.601T=0.399
The Genome Aggregation DatabaseEuropeSub18492C=0.918T=0.081
The Genome Aggregation DatabaseGlobalStudy-wide29966C=0.879T=0.120
The Genome Aggregation DatabaseOtherSub302C=0.900T=0.100
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.884T=0.115
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.926T=0.074
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs28917860.000893alcohol dependence20201924

eQTL of rs2891786 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2891786 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7104523797104525004E067-33935
chr7104540630104540996E067-17943
chr7104541178104541350E067-17589
chr7104541368104541642E067-17297
chr7104541811104541929E067-17010
chr7104562682104564036E0673743
chr7104601201104601939E06742262
chr7104523290104523507E068-35432
chr7104523547104523607E068-35332
chr7104523647104523715E068-35224
chr7104523797104525004E068-33935
chr7104540630104540996E068-17943
chr7104541178104541350E068-17589
chr7104541368104541642E068-17297
chr7104541811104541929E068-17010
chr7104542459104542549E068-16390
chr7104571535104571655E06812596
chr7104571669104572215E06812730
chr7104601201104601939E06842262
chr7104523290104523507E069-35432
chr7104523547104523607E069-35332
chr7104523647104523715E069-35224
chr7104523797104525004E069-33935
chr7104540630104540996E069-17943
chr7104541178104541350E069-17589
chr7104541368104541642E069-17297
chr7104541811104541929E069-17010
chr7104542459104542549E069-16390
chr7104562682104564036E0693743
chr7104571535104571655E06912596
chr7104571669104572215E06912730
chr7104601201104601939E06942262
chr7104540630104540996E070-17943
chr7104541178104541350E070-17589
chr7104541368104541642E070-17297
chr7104571669104572215E07012730
chr7104523290104523507E071-35432
chr7104523547104523607E071-35332
chr7104523647104523715E071-35224
chr7104539952104540012E071-18927
chr7104541811104541929E071-17010
chr7104542459104542549E071-16390
chr7104554813104554936E071-4003
chr7104554981104555172E071-3767
chr7104562682104564036E0713743
chr7104583728104583780E07124789
chr7104583848104585211E07124909
chr7104585322104586192E07126383
chr7104601201104601939E07142262
chr7104602384104602664E07143445
chr7104523797104525004E072-33935
chr7104540630104540996E072-17943
chr7104541178104541350E072-17589
chr7104541368104541642E072-17297
chr7104541811104541929E072-17010
chr7104554813104554936E072-4003
chr7104554981104555172E072-3767
chr7104601201104601939E07242262
chr7104523797104525004E073-33935
chr7104540630104540996E073-17943
chr7104541178104541350E073-17589
chr7104541368104541642E073-17297
chr7104541811104541929E073-17010
chr7104562682104564036E0733743
chr7104523797104525004E074-33935
chr7104525154104525268E074-33671
chr7104525338104525388E074-33551
chr7104540630104540996E074-17943
chr7104541178104541350E074-17589
chr7104541368104541642E074-17297
chr7104541811104541929E074-17010
chr7104554813104554936E074-4003
chr7104554981104555172E074-3767
chr7104562682104564036E0743743
chr7104571669104572215E07412730
chr7104573228104573689E07414289
chr7104573749104573964E07414810
chr7104585322104586192E07426383
chr7104601201104601939E07442262
chr7104602216104602313E07443277
chr7104602384104602664E07443445