rs2912089

Homo sapiens
G>A / G>C
None
Check p-value
SNV (Single Nucleotide Variation)
A=0253 (7600/29940,GnomAD)
A=0301 (8767/29118,TOPMED)
A=0335 (1676/5008,1000G)
A=0140 (539/3854,ALSPAC)
A=0142 (525/3708,TWINSUK)
chr8:6777253 (GRCh38.p7) (8p23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
14 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.6777253G>A
GRCh38.p7 chr 8NC_000008.11:g.6777253G>C
GRCh37.p13 chr 8NC_000008.10:g.6634774G>A
GRCh37.p13 chr 8NC_000008.10:g.6634774G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.427A=0.573
1000GenomesAmericanSub694G=0.770A=0.230
1000GenomesEast AsianSub1008G=0.721A=0.279
1000GenomesEuropeSub1006G=0.853A=0.147
1000GenomesGlobalStudy-wide5008G=0.665A=0.335
1000GenomesSouth AsianSub978G=0.660A=0.340
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.860A=0.140
The Genome Aggregation DatabaseAfricanSub8704G=0.506A=0.494
The Genome Aggregation DatabaseAmericanSub838G=0.780A=0.22,
The Genome Aggregation DatabaseEast AsianSub1616G=0.716A=0.284
The Genome Aggregation DatabaseEuropeSub18480G=0.859A=0.140
The Genome Aggregation DatabaseGlobalStudy-wide29940G=0.746A=0.253
The Genome Aggregation DatabaseOtherSub302G=0.810A=0.19,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.698A=0.301
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.858A=0.142
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs29120890.000037alcohol dependence20201924
rs29120890.0000372alcoholismpha002893
rs29120890.00016alcohol dependence(early age of onset)20201924

eQTL of rs2912089 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2912089 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr86294002262940758E069-8151
chr86294097762941044E069-7865
chr86292641862926697E070-22212
chr86292676662926835E070-22074
chr86292688562927029E070-21880
chr86294097762941044E070-7865
chr86293958262939793E072-9116
chr86292374362924635E081-24274
chr86292469862924784E081-24125
chr86293936362939428E081-9481
chr86293958262939793E081-9116
chr86294097762941044E081-7865
chr86292374362924635E082-24274
chr86293958262939793E082-9116