rs2921010

Homo sapiens
G>A
SGK223 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0182 (5476/29942,GnomAD)
A=0233 (6797/29118,TOPMED)
A=0200 (1004/5008,1000G)
A=0148 (570/3854,ALSPAC)
A=0153 (566/3708,TWINSUK)
chr8:8372845 (GRCh38.p7) (8p23.1)
ND
GWASdb2
1   publication(s)
See rs on genome
163 Enhancers around
17 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.8372845G>A
GRCh37.p13 chr 8NC_000008.10:g.8230361G>A

Gene: SGK223, homolog of rat pragma of Rnd2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PRAG1 transcriptNM_001080826.2:c.N/AIntron Variant
SGK223 transcript variant X1XM_005272369.4:c.N/AIntron Variant
SGK223 transcript variant X2XM_005272370.4:c.N/AIntron Variant
SGK223 transcript variant X3XM_011543813.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.658A=0.342
1000GenomesAmericanSub694G=0.890A=0.110
1000GenomesEast AsianSub1008G=0.901A=0.099
1000GenomesEuropeSub1006G=0.871A=0.129
1000GenomesGlobalStudy-wide5008G=0.800A=0.200
1000GenomesSouth AsianSub978G=0.750A=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.852A=0.148
The Genome Aggregation DatabaseAfricanSub8706G=0.688A=0.312
The Genome Aggregation DatabaseAmericanSub836G=0.870A=0.130
The Genome Aggregation DatabaseEast AsianSub1616G=0.884A=0.116
The Genome Aggregation DatabaseEuropeSub18482G=0.869A=0.130
The Genome Aggregation DatabaseGlobalStudy-wide29942G=0.817A=0.182
The Genome Aggregation DatabaseOtherSub302G=0.790A=0.210
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.766A=0.233
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.847A=0.153
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs29210103.35E-06alcohol and nictotine co-dependence20158304

eQTL of rs2921010 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2921010 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr881813098181494E067-48867
chr881815078182951E067-47410
chr881908278191793E067-38568
chr881918458192218E067-38143
chr881813098181494E068-48867
chr881877998189019E068-41342
chr881890248189093E068-41268
chr881891098189511E068-40850
chr881905618190639E068-39722
chr881908278191793E068-38568
chr881918458192218E068-38143
chr881979998198156E068-32205
chr881982328198789E068-31572
chr882061698206583E068-23778
chr882257048226654E068-3707
chr882300018230051E068-310
chr882305948230807E068233
chr882403578240475E0689996
chr882406318240681E06810270
chr882407118240761E06810350
chr882761268276712E06845765
chr882767198277020E06846358
chr881813098181494E069-48867
chr881890248189093E069-41268
chr881908278191793E069-38568
chr881918458192218E069-38143
chr881932208193320E069-37041
chr882312638231782E069902
chr882318758232007E0691514
chr882366868237031E0696325
chr882371258237176E0696764
chr882372508237362E0696889
chr882560038257073E06925642
chr882724708272551E06942109
chr881838358183889E070-46472
chr881841638184219E070-46142
chr881877998189019E070-41342
chr881890248189093E070-41268
chr881891098189511E070-40850
chr881900408190137E070-40224
chr881902148190522E070-39839
chr881905618190639E070-39722
chr881908278191793E070-38568
chr881918458192218E070-38143
chr881924348192543E070-37818
chr881927028192773E070-37588
chr881927778192827E070-37534
chr881932208193320E070-37041
chr881934628193512E070-36849
chr882277248227964E070-2397
chr882280988228310E070-2051
chr882312638231782E070902
chr882541978254267E07023836
chr882543138254394E07023952
chr882545308254667E07024169
chr882560038257073E07025642
chr882775418277887E07047180
chr882779598278009E07047598
chr881813098181494E071-48867
chr881877998189019E071-41342
chr881890248189093E071-41268
chr881902148190522E071-39839
chr881905618190639E071-39722
chr881908278191793E071-38568
chr881918458192218E071-38143
chr881934628193512E071-36849
chr881936618194322E071-36039
chr881956278195750E071-34611
chr881958028195918E071-34443
chr881959218196014E071-34347
chr881960298196848E071-33513
chr882061698206583E071-23778
chr882560038257073E07125642
chr882724708272551E07142109
chr882761268276712E07145765
chr881908278191793E072-38568
chr882305948230807E072233
chr882312638231782E072902
chr882318758232007E0721514
chr882320578232147E0721696
chr882321498232203E0721788
chr882724708272551E07242109
chr881813098181494E073-48867
chr881815078182951E073-47410
chr881890248189093E073-41268
chr881902148190522E073-39839
chr881905618190639E073-39722
chr881908278191793E073-38568
chr882277248227964E073-2397
chr882280988228310E073-2051
chr882336208233820E0733259
chr882338558233978E0733494
chr882345108234596E0734149
chr881813098181494E074-48867
chr881890248189093E074-41268
chr881902148190522E074-39839
chr881905618190639E074-39722
chr881908278191793E074-38568
chr881918458192218E074-38143
chr882553398255979E07424978
chr882560038257073E07425642
chr882572118257306E07426850
chr882767198277020E07446358
chr882770618277111E07446700
chr881813098181494E081-48867
chr881815078182951E081-47410
chr881890248189093E081-41268
chr881891098189511E081-40850
chr881908278191793E081-38568
chr881918458192218E081-38143
chr881924348192543E081-37818
chr881927028192773E081-37588
chr881927778192827E081-37534
chr881932208193320E081-37041
chr881934628193512E081-36849
chr881936618194322E081-36039
chr881982328198789E081-31572
chr881988078199073E081-31288
chr882054908205739E081-24622
chr882057738205861E081-24500
chr882058698205998E081-24363
chr882061698206583E081-23778
chr882071288207194E081-23167
chr882072338207422E081-22939
chr882074258207465E081-22896
chr882300018230051E081-310
chr882305948230807E081233
chr882312638231782E081902
chr882318758232007E0811514
chr882333448233465E0812983
chr882336208233820E0813259
chr882338558233978E0813494
chr882393118239395E0818950
chr882560038257073E08125642
chr882572118257306E08126850
chr882745678275103E08144206
chr882761268276712E08145765
chr881813098181494E082-48867
chr881905618190639E082-39722
chr881908278191793E082-38568
chr881934628193512E082-36849
chr881936618194322E082-36039
chr881988078199073E082-31288
chr882054908205739E082-24622
chr882057738205861E082-24500
chr882058698205998E082-24363
chr882255998225684E082-4677
chr882267718226821E082-3540
chr882269178226967E082-3394
chr882272548227391E082-2970
chr882277248227964E082-2397
chr882300018230051E082-310
chr882312638231782E082902
chr882318758232007E0821514
chr882320578232147E0821696
chr882321498232203E0821788
chr882332738233313E0822912
chr882333448233465E0822983
chr882336208233820E0823259
chr882338558233978E0823494
chr882560038257073E08225642
chr882761268276712E08245765
chr882767198277020E08246358










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr882425818242631E06712220
chr882426588245274E06712297
chr882425818242631E06812220
chr882426588245274E06812297
chr882426588245274E06912297
chr882425818242631E07012220
chr882426588245274E07012297
chr882425818242631E07112220
chr882426588245274E07112297
chr882425818242631E07212220
chr882426588245274E07212297
chr882425818242631E07312220
chr882426588245274E07312297
chr882426588245274E07412297
chr882425818242631E08112220
chr882425818242631E08212220
chr882426588245274E08212297