rs2945891

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0447 (13388/29948,GnomAD)
A=0403 (11744/29118,TOPMED)
G==0492 (2463/5008,1000G)
A=0463 (1783/3854,ALSPAC)
A=0459 (1701/3708,TWINSUK)
chr8:8297953 (GRCh38.p7) (8p23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
148 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.8297953G>A
GRCh37.p13 chr 8NC_000008.10:g.8155475G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.715A=0.285
1000GenomesAmericanSub694G=0.400A=0.600
1000GenomesEast AsianSub1008G=0.116A=0.884
1000GenomesEuropeSub1006G=0.567A=0.433
1000GenomesGlobalStudy-wide5008G=0.492A=0.508
1000GenomesSouth AsianSub978G=0.570A=0.430
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.537A=0.463
The Genome Aggregation DatabaseAfricanSub8716G=0.701A=0.299
The Genome Aggregation DatabaseAmericanSub836G=0.340A=0.660
The Genome Aggregation DatabaseEast AsianSub1620G=0.122A=0.878
The Genome Aggregation DatabaseEuropeSub18480G=0.529A=0.470
The Genome Aggregation DatabaseGlobalStudy-wide29948G=0.553A=0.447
The Genome Aggregation DatabaseOtherSub296G=0.650A=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.596A=0.403
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.541A=0.459
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs29458910.000171alcohol dependence21314694

eQTL of rs2945891 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr8:8155475ENPP7P1ENSG00000249188.1G>A1.7288e-7143645Cerebellum
Chr8:8155475FAM85BENSG00000253893.2G>A1.4252e-1671339Cerebellum
Chr8:8155475FAM86B3PENSG00000173295.3G>A5.4818e-2169358Cerebellum
Chr8:8155475FAM85BENSG00000253893.2G>A3.2575e-1471339Frontal_Cortex_BA9
Chr8:8155475FAM86B3PENSG00000173295.3G>A1.0000e-1569358Frontal_Cortex_BA9
Chr8:8155475FAM85BENSG00000253893.2G>A5.3815e-1271339Hypothalamus
Chr8:8155475FAM85BENSG00000253893.2G>A5.1485e-1871339Cortex
Chr8:8155475FAM86B3PENSG00000173295.3G>A3.1984e-1769358Cortex
Chr8:8155475FAM85BENSG00000253893.2G>A8.2828e-1271339Cerebellar_Hemisphere
Chr8:8155475FAM86B3PENSG00000173295.3G>A1.5384e-1569358Cerebellar_Hemisphere
Chr8:8155475FAM85BENSG00000253893.2G>A2.0058e-1171339Caudate_basal_ganglia
Chr8:8155475FAM85BENSG00000253893.2G>A5.7812e-971339Brain_Spinal_cord_cervical
Chr8:8155475FAM85BENSG00000253893.2G>A1.8548e-1171339Hippocampus
Chr8:8155475RP11-62H7.2ENSG00000233609.3G>A3.9269e-7-663235Hippocampus
Chr8:8155475FAM85BENSG00000253893.2G>A1.1472e-971339Substantia_nigra
Chr8:8155475FAM85BENSG00000253893.2G>A3.3672e-971339Putamen_basal_ganglia
Chr8:8155475FAM85BENSG00000253893.2G>A2.7226e-1871339Anterior_cingulate_cortex
Chr8:8155475FAM86B3PENSG00000173295.3G>A1.8808e-1169358Anterior_cingulate_cortex
Chr8:8155475FAM85BENSG00000253893.2G>A2.0406e-1371339Nucleus_accumbens_basal_ganglia
Chr8:8155475FAM85BENSG00000253893.2G>A5.6829e-1271339Amygdala

meQTL of rs2945891 in Fetal Brain

Probe ID Position Gene beta p-value
cg21775007chr8:11205619TDH0.03948185201310759.4602e-9

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr881675228167646E06712047
chr881677538167817E06712278
chr881679028168882E06712427
chr881689818169039E06713506
chr881813098181494E06725834
chr881815078182951E06726032
chr881908278191793E06735352
chr881918458192218E06736370
chr881440298144397E068-11078
chr881444888144893E068-10582
chr881449248145446E068-10029
chr881628498164076E0687374
chr881672728167477E06811797
chr881675228167646E06812047
chr881677538167817E06812278
chr881679028168882E06812427
chr881689818169039E06813506
chr881694288169666E06813953
chr881697138169812E06814238
chr881699398170465E06814464
chr881704908170582E06815015
chr881706628170719E06815187
chr881708448170930E06815369
chr881709788171079E06815503
chr881711228171191E06815647
chr881813098181494E06825834
chr881877998189019E06832324
chr881890248189093E06833549
chr881891098189511E06833634
chr881905618190639E06835086
chr881908278191793E06835352
chr881918458192218E06836370
chr881979998198156E06842524
chr881982328198789E06842757
chr881675228167646E06912047
chr881677538167817E06912278
chr881679028168882E06912427
chr881706628170719E06915187
chr881708448170930E06915369
chr881709788171079E06915503
chr881711228171191E06915647
chr881813098181494E06925834
chr881890248189093E06933549
chr881908278191793E06935352
chr881918458192218E06936370
chr881932208193320E06937745
chr881298048130181E070-25294
chr881303918130576E070-24899
chr881386028138717E070-16758
chr881387398138819E070-16656
chr881391238139235E070-16240
chr881738248173874E07018349
chr881838358183889E07028360
chr881841638184219E07028688
chr881877998189019E07032324
chr881890248189093E07033549
chr881891098189511E07033634
chr881900408190137E07034565
chr881902148190522E07034739
chr881905618190639E07035086
chr881908278191793E07035352
chr881918458192218E07036370
chr881924348192543E07036959
chr881927028192773E07037227
chr881927778192827E07037302
chr881932208193320E07037745
chr881934628193512E07037987
chr881671878167237E07111712
chr881672728167477E07111797
chr881675228167646E07112047
chr881677538167817E07112278
chr881679028168882E07112427
chr881689818169039E07113506
chr881694288169666E07113953
chr881697138169812E07114238
chr881699398170465E07114464
chr881704908170582E07115015
chr881706628170719E07115187
chr881708448170930E07115369
chr881709788171079E07115503
chr881711228171191E07115647
chr881740488174209E07118573
chr881813098181494E07125834
chr881877998189019E07132324
chr881890248189093E07133549
chr881902148190522E07134739
chr881905618190639E07135086
chr881908278191793E07135352
chr881918458192218E07136370
chr881934628193512E07137987
chr881936618194322E07138186
chr881956278195750E07140152
chr881958028195918E07140327
chr881959218196014E07140446
chr881960298196848E07140554
chr881672728167477E07211797
chr881675228167646E07212047
chr881677538167817E07212278
chr881679028168882E07212427
chr881908278191793E07235352
chr881675228167646E07312047
chr881677538167817E07312278
chr881679028168882E07312427
chr881813098181494E07325834
chr881815078182951E07326032
chr881890248189093E07333549
chr881902148190522E07334739
chr881905618190639E07335086
chr881908278191793E07335352
chr881671878167237E07411712
chr881672728167477E07411797
chr881675228167646E07412047
chr881677538167817E07412278
chr881679028168882E07412427
chr881689818169039E07413506
chr881694288169666E07413953
chr881706628170719E07415187
chr881708448170930E07415369
chr881709788171079E07415503
chr881711228171191E07415647
chr881813098181494E07425834
chr881890248189093E07433549
chr881902148190522E07434739
chr881905618190639E07435086
chr881908278191793E07435352
chr881918458192218E07436370
chr881628498164076E0817374
chr881813098181494E08125834
chr881815078182951E08126032
chr881890248189093E08133549
chr881891098189511E08133634
chr881908278191793E08135352
chr881918458192218E08136370
chr881924348192543E08136959
chr881927028192773E08137227
chr881927778192827E08137302
chr881932208193320E08137745
chr881934628193512E08137987
chr881936618194322E08138186
chr881982328198789E08142757
chr881988078199073E08143332
chr881744688175465E08218993
chr881813098181494E08225834
chr881905618190639E08235086
chr881908278191793E08235352
chr881934628193512E08237987
chr881936618194322E08238186
chr881988078199073E08243332