rs2952768

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0352 (10517/29798,GnomAD)
C=0338 (9851/29118,TOPMED)
C=0386 (1935/5008,1000G)
C=0363 (1400/3854,ALSPAC)
C=0372 (1381/3708,TWINSUK)
chr2:207629510 (GRCh38.p7) (2q33.3)
OD
GWASdb2 | GWASCatalog
5   publication(s)
See rs on genome
23 Enhancers around
27 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.207629510T>C
GRCh37.p13 chr 2NC_000002.11:g.208494234T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.707C=0.293
1000GenomesAmericanSub694T=0.590C=0.410
1000GenomesEast AsianSub1008T=0.596C=0.404
1000GenomesEuropeSub1006T=0.646C=0.354
1000GenomesGlobalStudy-wide5008T=0.614C=0.386
1000GenomesSouth AsianSub978T=0.490C=0.510
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.637C=0.363
The Genome Aggregation DatabaseAfricanSub8686T=0.690C=0.310
The Genome Aggregation DatabaseAmericanSub836T=0.560C=0.440
The Genome Aggregation DatabaseEast AsianSub1608T=0.593C=0.407
The Genome Aggregation DatabaseEuropeSub18368T=0.634C=0.365
The Genome Aggregation DatabaseGlobalStudy-wide29798T=0.647C=0.352
The Genome Aggregation DatabaseOtherSub300T=0.710C=0.290
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.661C=0.338
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.628C=0.372
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry
25615449Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses.Yoshida KPLoS One
23766564Pharmacogenetics of chronic pain and its treatment.Svetlik SMediators Inflamm
22992668Pharmacogenomics knowledge for personalized medicine.Whirl-Carrillo MClin Pharmacol Ther
26736037Single nucleotide polymorphism near CREB1, rs7591784, is associated with pretreatment methamphetamine use frequency and outcome of outpatient treatment for methamphetamine use disorder.Heinzerling KGJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs29527688E-07Opioid sensitivity23183491

eQTL of rs2952768 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2952768 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2208444458208444576E067-49658
chr2208467556208467656E067-26578
chr2208467955208468204E067-26030
chr2208468345208468451E067-25783
chr2208467955208468204E068-26030
chr2208468345208468451E068-25783
chr2208467556208467656E069-26578
chr2208467955208468204E069-26030
chr2208468345208468451E069-25783
chr2208528918208529061E07034684
chr2208530054208530175E07035820
chr2208530194208530330E07035960
chr2208468345208468451E071-25783
chr2208477393208477872E071-16362
chr2208467556208467656E072-26578
chr2208467955208468204E072-26030
chr2208468345208468451E072-25783
chr2208477393208477872E072-16362
chr2208482460208482572E072-11662
chr2208486395208486519E073-7715
chr2208487298208487338E073-6896
chr2208491753208492513E073-1721
chr2208444458208444576E074-49658








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2208488612208488838E067-5396
chr2208488906208491332E067-2902
chr2208488612208488838E068-5396
chr2208488906208491332E068-2902
chr2208491433208491516E068-2718
chr2208491536208491597E068-2637
chr2208491630208491681E068-2553
chr2208488612208488838E069-5396
chr2208488906208491332E069-2902
chr2208488612208488838E070-5396
chr2208488906208491332E070-2902
chr2208488612208488838E071-5396
chr2208488906208491332E071-2902
chr2208491433208491516E071-2718
chr2208491536208491597E071-2637
chr2208491630208491681E071-2553
chr2208488612208488838E072-5396
chr2208488906208491332E072-2902
chr2208488612208488838E073-5396
chr2208488906208491332E073-2902
chr2208488612208488838E074-5396
chr2208488906208491332E074-2902
chr2208488906208491332E081-2902
chr2208488612208488838E082-5396
chr2208488906208491332E082-2902
chr2208491433208491516E082-2718
chr2208491536208491597E082-2637