rs2977343

Homo sapiens
C>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0044 (1331/29944,GnomAD)
G=0040 (1186/29118,TOPMED)
G=0024 (118/5008,1000G)
G=0072 (279/3854,ALSPAC)
G=0070 (259/3708,TWINSUK)
chr8:75814512 (GRCh38.p7) (8q21.13)
ND
GWASdb2
1   publication(s)
See rs on genome
9 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.75814512C>G
GRCh37.p13 chr 8NC_000008.10:g.76726747C>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.996G=0.004
1000GenomesAmericanSub694C=0.980G=0.020
1000GenomesEast AsianSub1008C=0.999G=0.001
1000GenomesEuropeSub1006C=0.931G=0.069
1000GenomesGlobalStudy-wide5008C=0.976G=0.024
1000GenomesSouth AsianSub978C=0.970G=0.030
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.928G=0.072
The Genome Aggregation DatabaseAfricanSub8718C=0.987G=0.013
The Genome Aggregation DatabaseAmericanSub838C=0.980G=0.020
The Genome Aggregation DatabaseEast AsianSub1616C=1.000G=0.000
The Genome Aggregation DatabaseEuropeSub18470C=0.936G=0.063
The Genome Aggregation DatabaseGlobalStudy-wide29944C=0.955G=0.044
The Genome Aggregation DatabaseOtherSub302C=0.920G=0.080
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.959G=0.040
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.930G=0.070
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs29773430.000373nicotine dependence17158188

eQTL of rs2977343 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2977343 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr87669325876693413E070-33334
chr87669436676694446E070-32301
chr87669477376695324E070-31423
chr87672326276723527E070-3220
chr87672391276723993E070-2754
chr87672411476724164E070-2583
chr87673296176733201E0706214
chr87673333776733381E0706590
chr87668470776685561E081-41186