rs3018100

Homo sapiens
C>G
RPS3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0263 (7881/29916,GnomAD)
G=0246 (7179/29118,TOPMED)
G=0204 (1021/5008,1000G)
G=0377 (1454/3854,ALSPAC)
G=0373 (1383/3708,TWINSUK)
chr11:75417295 (GRCh38.p7) (11q13.4)
AD
GWASCatalog
1   publication(s)
See rs on genome
164 Enhancers around
17 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.75417295C>G
GRCh37.p13 chr 11NC_000011.9:g.75128339C>G

Gene: RPS3, ribosomal protein S3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RPS3 transcript variant 2NM_001256802.1:c.N/AIntron Variant
RPS3 transcript variant 1NM_001005.4:c.N/AGenic Downstream Transcript Variant
RPS3 transcript variant 3NM_001260506.1:c.N/AGenic Downstream Transcript Variant
RPS3 transcript variant 4NM_001260507.1:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.902G=0.098
1000GenomesAmericanSub694C=0.790G=0.210
1000GenomesEast AsianSub1008C=0.783G=0.217
1000GenomesEuropeSub1006C=0.674G=0.326
1000GenomesGlobalStudy-wide5008C=0.796G=0.204
1000GenomesSouth AsianSub978C=0.790G=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.623G=0.377
The Genome Aggregation DatabaseAfricanSub8716C=0.862G=0.138
The Genome Aggregation DatabaseAmericanSub834C=0.790G=0.210
The Genome Aggregation DatabaseEast AsianSub1610C=0.770G=0.230
The Genome Aggregation DatabaseEuropeSub18454C=0.673G=0.326
The Genome Aggregation DatabaseGlobalStudy-wide29916C=0.736G=0.263
The Genome Aggregation DatabaseOtherSub302C=0.650G=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.753G=0.246
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.627G=0.373
PMID Title Author Journal
29071344Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou HJAMA Psychiatry

P-Value

SNP ID p-value Traits Study
rs30181005E-06alcohol dependence29071344

eQTL of rs3018100 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3018100 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr117509536075096110E067-32229
chr117513168475131744E0673345
chr117513176475131868E0673425
chr117513199975132039E0673660
chr117513209975132204E0673760
chr117513226975132386E0673930
chr117513239275132854E0674053
chr117509536075096110E068-32229
chr117509930675100628E068-27711
chr117511223575112498E068-15841
chr117511263575112685E068-15654
chr117511274875112823E068-15516
chr117511304975113240E068-15099
chr117511327075113320E068-15019
chr117511336375113766E068-14573
chr117511378575114046E068-14293
chr117511407175114443E068-13896
chr117511445575114520E068-13819
chr117511454875114602E068-13737
chr117513176475131868E0683425
chr117513199975132039E0683660
chr117513209975132204E0683760
chr117513226975132386E0683930
chr117513239275132854E0684053
chr117516542275165671E06837083
chr117516568575165860E06837346
chr117509536075096110E069-32229
chr117509930675100628E069-27711
chr117513138375131542E0693044
chr117513168475131744E0693345
chr117513176475131868E0693425
chr117513199975132039E0693660
chr117513209975132204E0693760
chr117513226975132386E0693930
chr117513239275132854E0694053
chr117516542275165671E06937083
chr117516568575165860E06937346
chr117516605575166155E06937716
chr117516616075166231E06937821
chr117511304975113240E070-15099
chr117511327075113320E070-15019
chr117511336375113766E070-14573
chr117511378575114046E070-14293
chr117512864775128718E070308
chr117512874775128879E070408
chr117512891175128962E070572
chr117512905275129110E070713
chr117512914375129312E070804
chr117512938275129453E0701043
chr117513110475131167E0702765
chr117513120175131310E0702862
chr117513138375131542E0703044
chr117513168475131744E0703345
chr117513176475131868E0703425
chr117513199975132039E0703660
chr117513209975132204E0703760
chr117513226975132386E0703930
chr117513239275132854E0704053
chr117513750475137609E0709165
chr117513761875137709E0709279
chr117513774875137791E0709409
chr117513803675138133E0709697
chr117513817175138211E0709832
chr117514484275145071E07016503
chr117517223075172530E07043891
chr117517258075172630E07044241
chr117509536075096110E071-32229
chr117509930675100628E071-27711
chr117510703075107085E071-21254
chr117511223575112498E071-15841
chr117511263575112685E071-15654
chr117511274875112823E071-15516
chr117511304975113240E071-15099
chr117511327075113320E071-15019
chr117513110475131167E0712765
chr117513120175131310E0712862
chr117513138375131542E0713044
chr117513168475131744E0713345
chr117513176475131868E0713425
chr117513199975132039E0713660
chr117513209975132204E0713760
chr117513226975132386E0713930
chr117513239275132854E0714053
chr117509536075096110E072-32229
chr117509930675100628E072-27711
chr117513110475131167E0722765
chr117513120175131310E0722862
chr117513138375131542E0723044
chr117513168475131744E0723345
chr117513176475131868E0723425
chr117513199975132039E0723660
chr117513209975132204E0723760
chr117513226975132386E0723930
chr117513239275132854E0724053
chr117516542275165671E07237083
chr117516568575165860E07237346
chr117511274875112823E073-15516
chr117511304975113240E073-15099
chr117511327075113320E073-15019
chr117511336375113766E073-14573
chr117513168475131744E0733345
chr117513176475131868E0733425
chr117513199975132039E0733660
chr117513209975132204E0733760
chr117516542275165671E07337083
chr117516568575165860E07337346
chr117516605575166155E07337716
chr117516616075166231E07337821
chr117516636475166404E07338025
chr117509536075096110E074-32229
chr117509930675100628E074-27711
chr117510609675106461E074-21878
chr117510678375106837E074-21502
chr117510689275106942E074-21397
chr117510696575107015E074-21324
chr117513138375131542E0743044
chr117513168475131744E0743345
chr117513176475131868E0743425
chr117513199975132039E0743660
chr117513209975132204E0743760
chr117513226975132386E0743930
chr117513239275132854E0744053
chr117516542275165671E07437083
chr117516568575165860E07437346
chr117516605575166155E07437716
chr117516616075166231E07437821
chr117516636475166404E07438025
chr117511223575112498E081-15841
chr117511263575112685E081-15654
chr117511274875112823E081-15516
chr117511304975113240E081-15099
chr117511327075113320E081-15019
chr117511336375113766E081-14573
chr117511378575114046E081-14293
chr117513209975132204E0813760
chr117513226975132386E0813930
chr117513239275132854E0814053
chr117516542275165671E08137083
chr117516568575165860E08137346
chr117516605575166155E08137716
chr117516616075166231E08137821
chr117516636475166404E08138025
chr117516655575166666E08138216
chr117511263575112685E082-15654
chr117511274875112823E082-15516
chr117511304975113240E082-15099
chr117511327075113320E082-15019
chr117511336375113766E082-14573
chr117511378575114046E082-14293
chr117513138375131542E0823044
chr117513168475131744E0823345
chr117513176475131868E0823425
chr117513199975132039E0823660
chr117513209975132204E0823760
chr117513226975132386E0823930
chr117513239275132854E0824053
chr117516542275165671E08237083
chr117516568575165860E08237346
chr117516605575166155E08237716
chr117516616075166231E08237821
chr117516636475166404E08238025
chr117516655575166666E08238216
chr117516709675167166E08238757
chr117517669975176879E08248360










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr117511014275112009E067-16330
chr117513880075139807E06710461
chr117511014275112009E068-16330
chr117513880075139807E06810461
chr117511014275112009E069-16330
chr117513880075139807E06910461
chr117511014275112009E070-16330
chr117511206775112122E070-16217
chr117511014275112009E071-16330
chr117511014275112009E072-16330
chr117513880075139807E07210461
chr117511014275112009E073-16330
chr117513880075139807E07310461
chr117511014275112009E074-16330
chr117511014275112009E082-16330
chr117511206775112122E082-16217
chr117513880075139807E08210461