rs307766

Homo sapiens
C>T
DENND3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0186 (5576/29912,GnomAD)
C==0170 (4967/29118,TOPMED)
C==0107 (536/5008,1000G)
C==0256 (987/3854,ALSPAC)
C==0257 (952/3708,TWINSUK)
chr8:141141614 (GRCh38.p7) (8q24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.141141614C>T
GRCh37.p13 chr 8NC_000008.10:g.142151713C>T

Gene: DENND3, DENN domain containing 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
DENND3 transcriptNM_014957.2:c.N/AIntron Variant
DENND3 transcript variant X1XM_005250838.4:c.N/AIntron Variant
DENND3 transcript variant X3XM_005250839.2:c.N/AIntron Variant
DENND3 transcript variant X4XM_005250840.4:c.N/AIntron Variant
DENND3 transcript variant X6XM_005250841.3:c.N/AIntron Variant
DENND3 transcript variant X6XM_005250842.4:c.N/AIntron Variant
DENND3 transcript variant X2XM_011516933.1:c.N/AIntron Variant
DENND3 transcript variant X8XM_011516934.2:c.N/AIntron Variant
DENND3 transcript variant X12XM_011516937.1:c.N/AIntron Variant
DENND3 transcript variant X17XM_011516941.2:c.N/AIntron Variant
DENND3 transcript variant X4XM_017013241.1:c.N/AIntron Variant
DENND3 transcript variant X10XM_017013242.1:c.N/AIntron Variant
DENND3 transcript variant X14XM_011516938.2:c.N/AGenic Upstream Transcript Variant
DENND3 transcript variant X16XM_011516939.2:c.N/AGenic Upstream Transcript Variant
DENND3 transcript variant X14XM_011516940.2:c.N/AGenic Upstream Transcript Variant
DENND3 transcript variant X17XM_017013243.1:c.N/AGenic Upstream Transcript Variant
DENND3 transcript variant X10XR_001745497.1:n.N/AIntron Variant
DENND3 transcript variant X13XR_001745498.1:n.N/AIntron Variant
DENND3 transcript variant X20XR_001745499.1:n.N/AIntron Variant
DENND3 transcript variant X9XR_928310.2:n.N/AIntron Variant
DENND3 transcript variant X19XR_928312.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.072T=0.928
1000GenomesAmericanSub694C=0.140T=0.860
1000GenomesEast AsianSub1008C=0.012T=0.988
1000GenomesEuropeSub1006C=0.246T=0.754
1000GenomesGlobalStudy-wide5008C=0.107T=0.893
1000GenomesSouth AsianSub978C=0.080T=0.920
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.256T=0.744
The Genome Aggregation DatabaseAfricanSub8704C=0.096T=0.904
The Genome Aggregation DatabaseAmericanSub838C=0.150T=0.850
The Genome Aggregation DatabaseEast AsianSub1622C=0.014T=0.986
The Genome Aggregation DatabaseEuropeSub18448C=0.243T=0.756
The Genome Aggregation DatabaseGlobalStudy-wide29912C=0.186T=0.813
The Genome Aggregation DatabaseOtherSub300C=0.310T=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.170T=0.829
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.257T=0.743
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs3077660.00066alcohol dependence21314694

eQTL of rs307766 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs307766 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8142125513142125582E067-26131
chr8142125591142126707E067-25006
chr8142126716142126766E067-24947
chr8142126817142127021E067-24692
chr8142127034142127956E067-23757
chr8142136190142136365E067-15348
chr8142136520142136672E067-15041
chr8142136733142137024E067-14689
chr8142101888142102024E068-49689
chr8142102106142102184E068-49529
chr8142105425142105955E068-45758
chr8142105984142106367E068-45346
chr8142125164142125424E068-26289
chr8142125513142125582E068-26131
chr8142125591142126707E068-25006
chr8142126716142126766E068-24947
chr8142126817142127021E068-24692
chr8142127034142127956E068-23757
chr8142128752142128877E068-22836
chr8142128980142129199E068-22514
chr8142129236142130112E068-21601
chr8142130719142130837E068-20876
chr8142130892142130960E068-20753
chr8142131132142131438E068-20275
chr8142142840142142894E068-8819
chr8142162131142163167E06810418
chr8142167146142167836E06815433
chr8142174122142174208E06822409
chr8142174291142174458E06822578
chr8142181866142182001E06830153
chr8142182206142182297E06830493
chr8142182435142182911E06830722
chr8142183087142183154E06831374
chr8142183192142183970E06831479
chr8142105984142106367E069-45346
chr8142106393142106938E069-44775
chr8142125164142125424E069-26289
chr8142125513142125582E069-26131
chr8142125591142126707E069-25006
chr8142126716142126766E069-24947
chr8142126817142127021E069-24692
chr8142127034142127956E069-23757
chr8142128017142128461E069-23252
chr8142136520142136672E069-15041
chr8142136733142137024E069-14689
chr8142143377142143513E069-8200
chr8142143542142143594E069-8119
chr8142143957142144197E069-7516
chr8142174122142174208E06922409
chr8142174291142174458E06922578
chr8142174525142175186E06922812
chr8142175243142175552E06923530
chr8142181866142182001E06930153
chr8142182206142182297E06930493
chr8142183192142183970E06931479
chr8142184037142184253E06932324
chr8142194225142194355E06942512
chr8142194692142195029E06942979
chr8142195128142195178E06943415
chr8142195184142195339E06943471
chr8142122805142123210E070-28503
chr8142123309142123377E070-28336
chr8142123378142123592E070-28121
chr8142123771142123825E070-27888
chr8142123868142123918E070-27795
chr8142123940142124145E070-27568
chr8142125164142125424E070-26289
chr8142125513142125582E070-26131
chr8142125591142126707E070-25006
chr8142126716142126766E070-24947
chr8142126817142127021E070-24692
chr8142127034142127956E070-23757
chr8142174122142174208E07022409
chr8142174291142174458E07022578
chr8142174525142175186E07022812
chr8142194225142194355E07042512
chr8142194432142194563E07042719
chr8142194692142195029E07042979
chr8142195128142195178E07043415
chr8142195184142195339E07043471
chr8142195363142195406E07043650
chr8142200406142200607E07048693
chr8142200652142200859E07048939
chr8142200916142201184E07049203
chr8142105984142106367E071-45346
chr8142106393142106938E071-44775
chr8142125164142125424E071-26289
chr8142125513142125582E071-26131
chr8142125591142126707E071-25006
chr8142126716142126766E071-24947
chr8142126817142127021E071-24692
chr8142127034142127956E071-23757
chr8142128017142128461E071-23252
chr8142128752142128877E071-22836
chr8142128980142129199E071-22514
chr8142130719142130837E071-20876
chr8142130892142130960E071-20753
chr8142136733142137024E071-14689
chr8142141870142142260E071-9453
chr8142143377142143513E071-8200
chr8142143542142143594E071-8119
chr8142174122142174208E07122409
chr8142175243142175552E07123530
chr8142181866142182001E07130153
chr8142125513142125582E072-26131
chr8142125591142126707E072-25006
chr8142126716142126766E072-24947
chr8142126817142127021E072-24692
chr8142127034142127956E072-23757
chr8142130892142130960E072-20753
chr8142131132142131438E072-20275
chr8142136733142137024E072-14689
chr8142168133142168854E07216420
chr8142174122142174208E07222409
chr8142174291142174458E07222578
chr8142179230142179649E07227517
chr8142179654142180569E07227941
chr8142183192142183970E07231479
chr8142105425142105955E073-45758
chr8142105984142106367E073-45346
chr8142106393142106938E073-44775
chr8142125164142125424E073-26289
chr8142125513142125582E073-26131
chr8142125591142126707E073-25006
chr8142126716142126766E073-24947
chr8142126817142127021E073-24692
chr8142127034142127956E073-23757
chr8142128017142128461E073-23252
chr8142128980142129199E073-22514
chr8142136520142136672E073-15041
chr8142136733142137024E073-14689
chr8142143957142144197E073-7516
chr8142154479142154533E0732766
chr8142154877142154960E0733164
chr8142155104142155176E0733391
chr8142161981142162095E07310268
chr8142162131142163167E07310418
chr8142165009142165108E07313296
chr8142174122142174208E07322409
chr8142174291142174458E07322578
chr8142175243142175552E07323530
chr8142179230142179649E07327517
chr8142181409142181798E07329696
chr8142181866142182001E07330153
chr8142182206142182297E07330493
chr8142182435142182911E07330722
chr8142183087142183154E07331374
chr8142183192142183970E07331479
chr8142105984142106367E074-45346
chr8142106393142106938E074-44775
chr8142125164142125424E074-26289
chr8142125513142125582E074-26131
chr8142125591142126707E074-25006
chr8142126716142126766E074-24947
chr8142126817142127021E074-24692
chr8142127034142127956E074-23757
chr8142128980142129199E074-22514
chr8142136520142136672E074-15041
chr8142136733142137024E074-14689
chr8142174291142174458E07422578
chr8142175243142175552E07423530
chr8142125164142125424E081-26289
chr8142125513142125582E081-26131
chr8142125591142126707E081-25006
chr8142126716142126766E081-24947
chr8142126817142127021E081-24692
chr8142127034142127956E081-23757
chr8142170816142172239E08119103
chr8142200406142200607E08148693
chr8142200652142200859E08148939
chr8142200916142201184E08149203
chr8142201603142201643E08149890
chr8142122805142123210E082-28503
chr8142123309142123377E082-28336
chr8142123378142123592E082-28121
chr8142126716142126766E082-24947
chr8142126817142127021E082-24692
chr8142127034142127956E082-23757
chr8142136733142137024E082-14689
chr8142194692142195029E08242979
chr8142195128142195178E08243415
chr8142199878142200079E08248165
chr8142200156142200236E08248443
chr8142200406142200607E08248693
chr8142200652142200859E08248939
chr8142200916142201184E08249203
chr8142201222142201286E08249509










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr8142137314142140678E067-11035
chr8142137314142140678E068-11035
chr8142137314142140678E069-11035
chr8142137314142140678E070-11035
chr8142137314142140678E071-11035
chr8142137314142140678E072-11035
chr8142137314142140678E073-11035
chr8142137314142140678E074-11035
chr8142137314142140678E082-11035