rs3121491

Homo sapiens
G>A
NRAP : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0400 (11987/29912,GnomAD)
G==0371 (10810/29118,TOPMED)
G==0408 (2042/5008,1000G)
G==0416 (1605/3854,ALSPAC)
G==0409 (1517/3708,TWINSUK)
chr10:113662237 (GRCh38.p7) (10q25.3)
AD
GWASdb2
1   publication(s)
See rs on genome
80 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.113662237G>A
GRCh37.p13 chr 10NC_000010.10:g.115421996G>A

Gene: NRAP, nebulin related anchoring protein(minus strand)

Molecule type Change Amino acid[Codon] SO Term
NRAP transcript variant 3NM_001261463.1:c.N/AIntron Variant
NRAP transcript variant 4NM_001322945.1:c.N/AIntron Variant
NRAP transcript variant 1NM_006175.4:c.N/AIntron Variant
NRAP transcript variant 2NM_198060.3:c.N/AIntron Variant
NRAP transcript variant X1XM_005269864.2:c.N/AIntron Variant
NRAP transcript variant X3XM_005269865.2:c.N/AIntron Variant
NRAP transcript variant X5XM_005269867.2:c.N/AIntron Variant
NRAP transcript variant X2XM_006717870.2:c.N/AIntron Variant
NRAP transcript variant X4XM_011539832.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.299A=0.701
1000GenomesAmericanSub694G=0.370A=0.630
1000GenomesEast AsianSub1008G=0.499A=0.501
1000GenomesEuropeSub1006G=0.440A=0.560
1000GenomesGlobalStudy-wide5008G=0.408A=0.592
1000GenomesSouth AsianSub978G=0.460A=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.416A=0.584
The Genome Aggregation DatabaseAfricanSub8706G=0.311A=0.689
The Genome Aggregation DatabaseAmericanSub834G=0.380A=0.620
The Genome Aggregation DatabaseEast AsianSub1614G=0.498A=0.502
The Genome Aggregation DatabaseEuropeSub18458G=0.436A=0.563
The Genome Aggregation DatabaseGlobalStudy-wide29912G=0.400A=0.599
The Genome Aggregation DatabaseOtherSub300G=0.370A=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.371A=0.628
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.409A=0.591
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs31214910.0005alcohol dependence20201924

eQTL of rs3121491 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3121491 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10115374384115374434E067-47562
chr10115374582115374632E067-47364
chr10115374709115374769E067-47227
chr10115465227115465297E06743231
chr10115465336115465508E06743340
chr10115465563115465833E06743567
chr10115470934115471654E06748938
chr10115374090115374373E068-47623
chr10115374384115374434E068-47562
chr10115374582115374632E068-47364
chr10115374709115374769E068-47227
chr10115465227115465297E06843231
chr10115465336115465508E06843340
chr10115465563115465833E06843567
chr10115465904115466035E06843908
chr10115469967115470087E06847971
chr10115470259115470360E06848263
chr10115470669115470719E06848673
chr10115470934115471654E06848938
chr10115374384115374434E069-47562
chr10115374582115374632E069-47364
chr10115441380115441485E06919384
chr10115465227115465297E06943231
chr10115465336115465508E06943340
chr10115466977115467043E06944981
chr10115467249115467484E06945253
chr10115470934115471654E06948938
chr10115391954115392024E070-29972
chr10115405992115406558E070-15438
chr10115470934115471654E07048938
chr10115374582115374632E071-47364
chr10115441380115441485E07119384
chr10115441627115442136E07119631
chr10115465227115465297E07143231
chr10115465336115465508E07143340
chr10115465563115465833E07143567
chr10115465904115466035E07143908
chr10115466485115466539E07144489
chr10115466598115466673E07144602
chr10115466977115467043E07144981
chr10115470669115470719E07148673
chr10115470934115471654E07148938
chr10115374582115374632E072-47364
chr10115374709115374769E072-47227
chr10115464768115465110E07242772
chr10115465125115465174E07243129
chr10115465227115465297E07243231
chr10115465336115465508E07243340
chr10115465563115465833E07243567
chr10115467249115467484E07245253
chr10115470934115471654E07248938
chr10115374384115374434E073-47562
chr10115465227115465297E07343231
chr10115465336115465508E07343340
chr10115465563115465833E07343567
chr10115465904115466035E07343908
chr10115466485115466539E07344489
chr10115466598115466673E07344602
chr10115466977115467043E07344981
chr10115470669115470719E07348673
chr10115470934115471654E07348938
chr10115373370115373410E074-48586
chr10115373431115373489E074-48507
chr10115465227115465297E07443231
chr10115465336115465508E07443340
chr10115465563115465833E07443567
chr10115470259115470360E07448263
chr10115470669115470719E07448673
chr10115470934115471654E07448938
chr10115405992115406558E081-15438
chr10115406807115406891E081-15105
chr10115407056115407228E081-14768
chr10115407275115407439E081-14557
chr10115407638115407838E081-14158
chr10115407887115407956E081-14040
chr10115404201115404875E082-17121
chr10115405992115406558E082-15438
chr10115406807115406891E082-15105
chr10115407638115407838E082-14158
chr10115407887115407956E082-14040










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr10115438390115441302E06716394
chr10115438390115441302E06816394
chr10115438390115441302E06916394
chr10115438390115441302E07016394
chr10115438390115441302E07116394
chr10115438390115441302E07216394
chr10115438390115441302E07316394
chr10115438390115441302E07416394
chr10115438390115441302E08216394