rs317028

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0461 (13760/29824,GnomAD)
T=0470 (13705/29116,TOPMED)
T=0466 (2336/5008,1000G)
T=0473 (1822/3854,ALSPAC)
T=0484 (1795/3708,TWINSUK)
chr4:35423761 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
4 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35423761C>T
GRCh37.p13 chr 4NC_000004.11:g.35425383C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.543T=0.457
1000GenomesAmericanSub694C=0.470T=0.530
1000GenomesEast AsianSub1008C=0.651T=0.349
1000GenomesEuropeSub1006C=0.557T=0.443
1000GenomesGlobalStudy-wide5008C=0.534T=0.466
1000GenomesSouth AsianSub978C=0.420T=0.580
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.527T=0.473
The Genome Aggregation DatabaseAfricanSub8700C=0.553T=0.447
The Genome Aggregation DatabaseAmericanSub834C=0.440T=0.560
The Genome Aggregation DatabaseEast AsianSub1582C=0.680T=0.320
The Genome Aggregation DatabaseEuropeSub18408C=0.523T=0.476
The Genome Aggregation DatabaseGlobalStudy-wide29824C=0.538T=0.461
The Genome Aggregation DatabaseOtherSub300C=0.580T=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29116C=0.529T=0.470
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.516T=0.484
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs3170280.000224nicotine dependence17158188

eQTL of rs317028 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs317028 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43546529835465454E06939915
chr43546529835465454E07139915
chr43546529835465454E07439915



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E06741447
chr43546683035466880E06941447
chr43546683035466880E07141447
chr43546683035466880E07241447