rs317045

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0461 (13739/29790,GnomAD)
A=0469 (13655/29118,TOPMED)
A=0462 (2315/5008,1000G)
A=0473 (1824/3854,ALSPAC)
A=0483 (1792/3708,TWINSUK)
chr4:35434119 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
4 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35434119G>A
GRCh37.p13 chr 4NC_000004.11:g.35435741G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.543A=0.457
1000GenomesAmericanSub694G=0.500A=0.500
1000GenomesEast AsianSub1008G=0.652A=0.348
1000GenomesEuropeSub1006G=0.557A=0.443
1000GenomesGlobalStudy-wide5008G=0.538A=0.462
1000GenomesSouth AsianSub978G=0.420A=0.580
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.527A=0.473
The Genome Aggregation DatabaseAfricanSub8698G=0.553A=0.447
The Genome Aggregation DatabaseAmericanSub828G=0.460A=0.540
The Genome Aggregation DatabaseEast AsianSub1576G=0.685A=0.315
The Genome Aggregation DatabaseEuropeSub18386G=0.522A=0.477
The Genome Aggregation DatabaseGlobalStudy-wide29790G=0.538A=0.461
The Genome Aggregation DatabaseOtherSub302G=0.580A=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.531A=0.469
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.517A=0.483
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs3170450.000484nicotine dependence17158188

eQTL of rs317045 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs317045 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43546529835465454E06929557
chr43546529835465454E07129557
chr43546529835465454E07429557



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E06731089
chr43546683035466880E06931089
chr43546683035466880E07131089
chr43546683035466880E07231089