rs325127

Homo sapiens
A>T
None
Check p-value
SNV (Single Nucleotide Variation)
A==0403 (12080/29922,GnomAD)
A==0441 (12849/29118,TOPMED)
A==0474 (2375/5008,1000G)
A==0258 (993/3854,ALSPAC)
A==0258 (956/3708,TWINSUK)
chr6:147485583 (GRCh38.p7) (6q24.3)
ND
GWASdb2
1   publication(s)
See rs on genome
14 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.147485583A>T
GRCh37.p13 chr 6NC_000006.11:g.147806719A>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.729T=0.271
1000GenomesAmericanSub694A=0.390T=0.610
1000GenomesEast AsianSub1008A=0.484T=0.516
1000GenomesEuropeSub1006A=0.271T=0.729
1000GenomesGlobalStudy-wide5008A=0.474T=0.526
1000GenomesSouth AsianSub978A=0.380T=0.620
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.258T=0.742
The Genome Aggregation DatabaseAfricanSub8704A=0.648T=0.352
The Genome Aggregation DatabaseAmericanSub838A=0.420T=0.580
The Genome Aggregation DatabaseEast AsianSub1614A=0.460T=0.540
The Genome Aggregation DatabaseEuropeSub18466A=0.283T=0.716
The Genome Aggregation DatabaseGlobalStudy-wide29922A=0.403T=0.596
The Genome Aggregation DatabaseOtherSub300A=0.350T=0.650
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.441T=0.558
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.258T=0.742
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs3251270.000413nicotine dependence17158188

eQTL of rs325127 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs325127 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6147797680147797917E068-8802
chr6147768276147768453E070-38266
chr6147768496147768764E070-37955
chr6147768771147769292E070-37427
chr6147769962147770075E070-36644
chr6147770162147770248E070-36471
chr6147770367147770500E070-36219
chr6147824746147825106E07018027
chr6147769342147769930E071-36789
chr6147769962147770075E071-36644
chr6147797161147797321E071-9398
chr6147797680147797917E071-8802
chr6147797680147797917E072-8802
chr6147797680147797917E074-8802





Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr6147827750147831995E06721031
chr6147827750147831995E06821031
chr6147827750147831995E06921031
chr6147827750147831995E07121031
chr6147827750147831995E07221031
chr6147827750147831995E07321031
chr6147827750147831995E07421031
chr6147827750147831995E08221031