rs33364

Homo sapiens
G>T
C16orf97 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0242 (7253/29878,GnomAD)
T=0226 (6602/29118,TOPMED)
T=0215 (1077/5008,1000G)
T=0313 (1206/3854,ALSPAC)
T=0307 (1140/3708,TWINSUK)
chr16:52055223 (GRCh38.p7) (16q12.1)
AD
GWASdb2
1   publication(s)
See rs on genome
59 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.52055223G>T
GRCh37.p13 chr 16NC_000016.9:g.52089135G>T

Gene: C16orf97, chromosome 16 open reading frame 97(minus strand)

Molecule type Change Amino acid[Codon] SO Term
C16orf97 transcriptNM_001242473.1:c.N/AIntron Variant
C16orf97 transcript variant X2XM_011523081.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.840T=0.160
1000GenomesAmericanSub694G=0.840T=0.160
1000GenomesEast AsianSub1008G=0.923T=0.077
1000GenomesEuropeSub1006G=0.699T=0.301
1000GenomesGlobalStudy-wide5008G=0.785T=0.215
1000GenomesSouth AsianSub978G=0.620T=0.380
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.687T=0.313
The Genome Aggregation DatabaseAfricanSub8696G=0.833T=0.167
The Genome Aggregation DatabaseAmericanSub836G=0.820T=0.180
The Genome Aggregation DatabaseEast AsianSub1602G=0.929T=0.071
The Genome Aggregation DatabaseEuropeSub18442G=0.704T=0.295
The Genome Aggregation DatabaseGlobalStudy-wide29878G=0.757T=0.242
The Genome Aggregation DatabaseOtherSub302G=0.700T=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.773T=0.226
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.693T=0.307
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs333640.000261alcohol dependence24277619

eQTL of rs33364 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs33364 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr165208576452086022E067-3113
chr165210192352102024E06712788
chr165210230252102953E06713167
chr165210296652103043E06713831
chr165210362352104187E06714488
chr165211256652113710E06723431
chr165210083952101427E06811704
chr165210192352102024E06812788
chr165210230252102953E06813167
chr165211256652113710E06823431
chr165208576452086022E069-3113
chr165210083952101427E06911704
chr165210192352102024E06912788
chr165210362352104187E06914488
chr165211023452110298E06921099
chr165211032152111014E06921186
chr165211153052111920E06922395
chr165211204252112096E06922907
chr165211256652113710E06923431
chr165210230252102953E07013167
chr165210296652103043E07013831
chr165210362352104187E07014488
chr165210435852104559E07015223
chr165211032152111014E07021186
chr165208576452086022E071-3113
chr165210192352102024E07112788
chr165210230252102953E07113167
chr165210296652103043E07113831
chr165210362352104187E07114488
chr165211009652110146E07120961
chr165211023452110298E07121099
chr165211256652113710E07123431
chr165208428852084756E072-4379
chr165208576452086022E072-3113
chr165210083952101427E07211704
chr165210192352102024E07212788
chr165210230252102953E07213167
chr165210362352104187E07214488
chr165211256652113710E07223431
chr165210230252102953E07313167
chr165210296652103043E07313831
chr165211256652113710E07323431
chr165208576452086022E074-3113
chr165210083952101427E07411704
chr165210192352102024E07412788
chr165210230252102953E07413167
chr165210296652103043E07413831
chr165210362352104187E07414488
chr165211023452110298E07421099
chr165211032152111014E07421186
chr165211256652113710E07423431
chr165212213852122427E08133003
chr165212251352122654E08133378
chr165212271352122768E08133578
chr165212284752122957E08133712
chr165212303552123153E08133900
chr165212325452123380E08134119
chr165212950952129670E08140374
chr165213046252130791E08141327