rs334524

Homo sapiens
A>T
TNS3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0407 (12201/29950,GnomAD)
A==0488 (14224/29118,TOPMED)
A==0459 (2297/5008,1000G)
A==0277 (1069/3854,ALSPAC)
A==0294 (1090/3708,TWINSUK)
chr7:47526559 (GRCh38.p7) (7p12.3)
AD
GWASCatalog
1   publication(s)
See rs on genome
202 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.47526559A>T
GRCh37.p13 chr 7NC_000007.13:g.47566157A>T

Gene: TNS3, tensin 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TNS3 transcriptNM_022748.11:c.N/AIntron Variant
TNS3 transcript variant X2XM_011515476.2:c.N/AIntron Variant
TNS3 transcript variant X4XM_011515477.2:c.N/AIntron Variant
TNS3 transcript variant X5XM_011515478.2:c.N/AIntron Variant
TNS3 transcript variant X7XM_011515480.2:c.N/AIntron Variant
TNS3 transcript variant X1XM_017012537.1:c.N/AIntron Variant
TNS3 transcript variant X3XM_017012538.1:c.N/AIntron Variant
TNS3 transcript variant X6XM_011515479.2:c.N/AGenic Upstream Transcript Variant
TNS3 transcript variant X8XM_011515481.2:c.N/AGenic Upstream Transcript Variant
TNS3 transcript variant X10XM_011515482.2:c.N/AGenic Upstream Transcript Variant
TNS3 transcript variant X10XM_011515483.2:c.N/AGenic Upstream Transcript Variant
TNS3 transcript variant X12XM_011515484.2:c.N/AGenic Upstream Transcript Variant
TNS3 transcript variant X9XM_017012539.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.774T=0.226
1000GenomesAmericanSub694A=0.330T=0.670
1000GenomesEast AsianSub1008A=0.413T=0.587
1000GenomesEuropeSub1006A=0.296T=0.704
1000GenomesGlobalStudy-wide5008A=0.459T=0.541
1000GenomesSouth AsianSub978A=0.340T=0.660
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.277T=0.723
The Genome Aggregation DatabaseAfricanSub8706A=0.691T=0.309
The Genome Aggregation DatabaseAmericanSub838A=0.350T=0.650
The Genome Aggregation DatabaseEast AsianSub1616A=0.452T=0.548
The Genome Aggregation DatabaseEuropeSub18488A=0.274T=0.725
The Genome Aggregation DatabaseGlobalStudy-wide29950A=0.407T=0.592
The Genome Aggregation DatabaseOtherSub302A=0.300T=0.700
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.488T=0.511
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.294T=0.706
PMID Title Author Journal
29460428Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter JAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs3345241E-06alcohol dependence29460428

eQTL of rs334524 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs334524 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr74752780547528207E067-37950
chr74752827847528424E067-37733
chr74753180447531867E067-34290
chr74753194747531997E067-34160
chr74753204047532127E067-34030
chr74753217947532269E067-33888
chr74753344947534681E067-31476
chr74753480947535367E067-30790
chr74753568747536081E067-30076
chr74753613347536277E067-29880
chr74753627847536329E067-29828
chr74753635847536536E067-29621
chr74754283247543341E067-22816
chr74754393247544038E067-22119
chr74754410047544251E067-21906
chr74754425647545005E067-21152
chr74754501347545209E067-20948
chr74754534647545463E067-20694
chr74754550947545619E067-20538
chr74754572947545790E067-20367
chr74760762447607715E06741467
chr74760777047607844E06741613
chr74760792547608790E06741768
chr74760973847612226E06743581
chr74752331847524072E068-42085
chr74752407347524315E068-41842
chr74752438847524548E068-41609
chr74752458047526242E068-39915
chr74753204047532127E068-34030
chr74753217947532269E068-33888
chr74753234547532821E068-33336
chr74753568747536081E068-30076
chr74753613347536277E068-29880
chr74753627847536329E068-29828
chr74753635847536536E068-29621
chr74753785647538008E068-28149
chr74754259947542719E068-23438
chr74754283247543341E068-22816
chr74754339747543471E068-22686
chr74754351147543591E068-22566
chr74754362547543715E068-22442
chr74754372347543777E068-22380
chr74754378947543872E068-22285
chr74754393247544038E068-22119
chr74754410047544251E068-21906
chr74754425647545005E068-21152
chr74754501347545209E068-20948
chr74754534647545463E068-20694
chr74754550947545619E068-20538
chr74755973147561163E068-4994
chr74757391747575961E0687760
chr74760762447607715E06841467
chr74760777047607844E06841613
chr74760792547608790E06841768
chr74760973847612226E06843581
chr74751675747516837E069-49320
chr74751685747517015E069-49142
chr74752407347524315E069-41842
chr74752438847524548E069-41609
chr74752458047526242E069-39915
chr74753180447531867E069-34290
chr74753194747531997E069-34160
chr74753480947535367E069-30790
chr74754259947542719E069-23438
chr74754410047544251E069-21906
chr74754425647545005E069-21152
chr74754501347545209E069-20948
chr74754534647545463E069-20694
chr74754550947545619E069-20538
chr74754572947545790E069-20367
chr74760762447607715E06941467
chr74760777047607844E06941613
chr74760792547608790E06941768
chr74760904447609109E06942887
chr74760924947609363E06943092
chr74760973847612226E06943581
chr74751845947519439E070-46718
chr74751952447519711E070-46446
chr74751977047522799E070-43358
chr74757391747575961E0707760
chr74759119447592005E07025037
chr74751705547518035E071-48122
chr74751832247518420E071-47737
chr74751845947519439E071-46718
chr74752331847524072E071-42085
chr74752407347524315E071-41842
chr74752438847524548E071-41609
chr74753344947534681E071-31476
chr74753480947535367E071-30790
chr74753568747536081E071-30076
chr74753613347536277E071-29880
chr74753627847536329E071-29828
chr74753635847536536E071-29621
chr74753660147537786E071-28371
chr74754088047541692E071-24465
chr74754170047542427E071-23730
chr74754247847542543E071-23614
chr74754259947542719E071-23438
chr74754283247543341E071-22816
chr74754339747543471E071-22686
chr74754351147543591E071-22566
chr74754362547543715E071-22442
chr74754372347543777E071-22380
chr74754378947543872E071-22285
chr74754393247544038E071-22119
chr74754410047544251E071-21906
chr74754425647545005E071-21152
chr74755134447551409E071-14748
chr74755148747551915E071-14242
chr74755193247552004E071-14153
chr74755315647554015E071-12142
chr74760712047607536E07140963
chr74760762447607715E07141467
chr74760777047607844E07141613
chr74760792547608790E07141768
chr74760904447609109E07142887
chr74760924947609363E07143092
chr74760973847612226E07143581
chr74761237147612412E07146214
chr74761247747612940E07146320
chr74761294947613177E07146792
chr74761321647614949E07147059
chr74754247847542543E072-23614
chr74754259947542719E072-23438
chr74754283247543341E072-22816
chr74754393247544038E072-22119
chr74754410047544251E072-21906
chr74754425647545005E072-21152
chr74760762447607715E07241467
chr74760777047607844E07241613
chr74760792547608790E07241768
chr74760973847612226E07243581
chr74751705547518035E073-48122
chr74752407347524315E073-41842
chr74752438847524548E073-41609
chr74752458047526242E073-39915
chr74753344947534681E073-31476
chr74753480947535367E073-30790
chr74753568747536081E073-30076
chr74753613347536277E073-29880
chr74753627847536329E073-29828
chr74753635847536536E073-29621
chr74754170047542427E073-23730
chr74754247847542543E073-23614
chr74754259947542719E073-23438
chr74754283247543341E073-22816
chr74754339747543471E073-22686
chr74754351147543591E073-22566
chr74754362547543715E073-22442
chr74754372347543777E073-22380
chr74754378947543872E073-22285
chr74754393247544038E073-22119
chr74754410047544251E073-21906
chr74754425647545005E073-21152
chr74760762447607715E07341467
chr74760777047607844E07341613
chr74760792547608790E07341768
chr74760973847612226E07343581
chr74753204047532127E074-34030
chr74753217947532269E074-33888
chr74753234547532821E074-33336
chr74753300647533062E074-33095
chr74753344947534681E074-31476
chr74753613347536277E074-29880
chr74753627847536329E074-29828
chr74753635847536536E074-29621
chr74754393247544038E074-22119
chr74754410047544251E074-21906
chr74754425647545005E074-21152
chr74754501347545209E074-20948
chr74754534647545463E074-20694
chr74754550947545619E074-20538
chr74754572947545790E074-20367
chr74754595547547691E074-18466
chr74760712047607536E07440963
chr74760762447607715E07441467
chr74760777047607844E07441613
chr74760792547608790E07441768
chr74760973847612226E07443581
chr74761294947613177E07446792
chr74751952447519711E081-46446
chr74753217947532269E081-33888
chr74753234547532821E081-33336
chr74753344947534681E081-31476
chr74753480947535367E081-30790
chr74753568747536081E081-30076
chr74753931347539569E081-26588
chr74754425647545005E081-21152
chr74754501347545209E081-20948
chr74754534647545463E081-20694
chr74754550947545619E081-20538
chr74754572947545790E081-20367
chr74754595547547691E081-18466
chr74755297047553025E081-13132
chr74755315647554015E081-12142
chr74755406247554488E081-11669
chr74755453547554734E081-11423
chr74757596647578402E0819809
chr74759090847591159E08124751
chr74759119447592005E08125037
chr74754410047544251E082-21906
chr74754425647545005E082-21152