rs33786

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0340 (10176/29900,GnomAD)
A=0321 (9352/29118,TOPMED)
A=0246 (1232/5008,1000G)
A=0449 (1732/3854,ALSPAC)
A=0446 (1654/3708,TWINSUK)

Position: chr3:45251887 (GRCh38.p7) (3p21.31)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 46 Enhancers around

Promoter: 53 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 3	NC_000003.12:g.45251887G>A
GRCh37.p13 chr 3	NC_000003.11:g.45293379G>A

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.871	A=0.129
1000Genomes	American	Sub	694	G=0.760	A=0.240
1000Genomes	East Asian	Sub	1008	G=0.823	A=0.177
1000Genomes	Europe	Sub	1006	G=0.533	A=0.467
1000Genomes	Global	Study-wide	5008	G=0.754	A=0.246
1000Genomes	South Asian	Sub	978	G=0.750	A=0.250
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.551	A=0.449
The Genome Aggregation Database	African	Sub	8708	G=0.838	A=0.162
The Genome Aggregation Database	American	Sub	838	G=0.770	A=0.230
The Genome Aggregation Database	East Asian	Sub	1616	G=0.798	A=0.202
The Genome Aggregation Database	Europe	Sub	18436	G=0.559	A=0.440
The Genome Aggregation Database	Global	Study-wide	29900	G=0.659	A=0.340
The Genome Aggregation Database	Other	Sub	302	G=0.600	A=0.400
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.678	A=0.321
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.554	A=0.446

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs33786	0.000855	alcohol dependence	20201924

eQTL of rs33786 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs33786 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr3	45268711	45268928	E068	-24451
chr3	45269001	45269053	E068	-24326
chr3	45269121	45269177	E068	-24202
chr3	45269193	45269243	E068	-24136
chr3	45268711	45268928	E069	-24451
chr3	45260119	45260238	E070	-33141
chr3	45269001	45269053	E070	-24326
chr3	45269121	45269177	E070	-24202
chr3	45269193	45269243	E070	-24136
chr3	45285506	45285688	E070	-7691
chr3	45285722	45286167	E070	-7212
chr3	45287865	45288158	E070	-5221
chr3	45268711	45268928	E071	-24451
chr3	45269001	45269053	E071	-24326
chr3	45269121	45269177	E071	-24202
chr3	45269193	45269243	E071	-24136
chr3	45268711	45268928	E072	-24451
chr3	45269001	45269053	E072	-24326
chr3	45269121	45269177	E072	-24202
chr3	45268711	45268928	E073	-24451
chr3	45269001	45269053	E073	-24326
chr3	45269121	45269177	E073	-24202
chr3	45269193	45269243	E073	-24136
chr3	45268711	45268928	E074	-24451
chr3	45269001	45269053	E074	-24326
chr3	45269121	45269177	E074	-24202
chr3	45269193	45269243	E074	-24136
chr3	45251928	45252734	E081	-40645
chr3	45253072	45253140	E081	-40239
chr3	45253346	45253574	E081	-39805
chr3	45253643	45253860	E081	-39519
chr3	45253911	45253961	E081	-39418
chr3	45257616	45257813	E081	-35566
chr3	45257978	45258035	E081	-35344
chr3	45260119	45260238	E081	-33141
chr3	45268711	45268928	E081	-24451
chr3	45269001	45269053	E081	-24326
chr3	45269121	45269177	E081	-24202
chr3	45269193	45269243	E081	-24136
chr3	45269326	45269724	E081	-23655
chr3	45285506	45285688	E081	-7691
chr3	45285722	45286167	E081	-7212
chr3	45287865	45288158	E081	-5221
chr3	45257085	45257168	E082	-36211
chr3	45257225	45257313	E082	-36066
chr3	45285722	45286167	E082	-7212

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr3	45266189	45266248	E067	-27131
chr3	45266370	45266635	E067	-26744
chr3	45266655	45266975	E067	-26404
chr3	45267130	45267324	E067	-26055
chr3	45267462	45268526	E067	-24853
chr3	45265536	45265694	E068	-27685
chr3	45266189	45266248	E068	-27131
chr3	45266370	45266635	E068	-26744
chr3	45266655	45266975	E068	-26404
chr3	45267130	45267324	E068	-26055
chr3	45267462	45268526	E068	-24853
chr3	45266189	45266248	E069	-27131
chr3	45266370	45266635	E069	-26744
chr3	45266655	45266975	E069	-26404
chr3	45267130	45267324	E069	-26055
chr3	45267462	45268526	E069	-24853
chr3	45265536	45265694	E070	-27685
chr3	45266189	45266248	E070	-27131
chr3	45266370	45266635	E070	-26744
chr3	45266655	45266975	E070	-26404
chr3	45267130	45267324	E070	-26055
chr3	45267462	45268526	E070	-24853
chr3	45266189	45266248	E071	-27131
chr3	45266370	45266635	E071	-26744
chr3	45266655	45266975	E071	-26404
chr3	45267130	45267324	E071	-26055
chr3	45267462	45268526	E071	-24853
chr3	45265536	45265694	E072	-27685
chr3	45266189	45266248	E072	-27131
chr3	45266370	45266635	E072	-26744
chr3	45266655	45266975	E072	-26404
chr3	45267130	45267324	E072	-26055
chr3	45267462	45268526	E072	-24853
chr3	45265536	45265694	E073	-27685
chr3	45266189	45266248	E073	-27131
chr3	45266370	45266635	E073	-26744
chr3	45266655	45266975	E073	-26404
chr3	45267130	45267324	E073	-26055
chr3	45267462	45268526	E073	-24853
chr3	45266370	45266635	E074	-26744
chr3	45266655	45266975	E074	-26404
chr3	45267130	45267324	E074	-26055
chr3	45267462	45268526	E074	-24853
chr3	45265536	45265694	E081	-27685
chr3	45266189	45266248	E081	-27131
chr3	45266370	45266635	E081	-26744
chr3	45266655	45266975	E081	-26404
chr3	45265536	45265694	E082	-27685
chr3	45266189	45266248	E082	-27131
chr3	45266370	45266635	E082	-26744
chr3	45266655	45266975	E082	-26404
chr3	45267130	45267324	E082	-26055
chr3	45267462	45268526	E082	-24853