rs35952

Homo sapiens
C>T
ARL15 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0275 (8238/29956,GnomAD)
C==0317 (9247/29118,TOPMED)
C==0391 (1957/5008,1000G)
C==0161 (620/3854,ALSPAC)
C==0156 (577/3708,TWINSUK)
chr5:54296333 (GRCh38.p7) (5q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.54296333C>T
GRCh37.p13 chr 5NC_000005.9:g.53592163C>T

Gene: ARL15, ADP ribosylation factor like GTPase 15(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL15 transcriptNM_019087.2:c.N/AIntron Variant
ARL15 transcript variant X1XM_011543498.2:c.N/AIntron Variant
ARL15 transcript variant X2XM_011543499.2:c.N/AIntron Variant
ARL15 transcript variant X3XM_011543500.2:c.N/AIntron Variant
ARL15 transcript variant X4XM_017009598.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.491T=0.509
1000GenomesAmericanSub694C=0.460T=0.540
1000GenomesEast AsianSub1008C=0.546T=0.454
1000GenomesEuropeSub1006C=0.154T=0.846
1000GenomesGlobalStudy-wide5008C=0.391T=0.609
1000GenomesSouth AsianSub978C=0.290T=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.161T=0.839
The Genome Aggregation DatabaseAfricanSub8706C=0.465T=0.535
The Genome Aggregation DatabaseAmericanSub836C=0.450T=0.550
The Genome Aggregation DatabaseEast AsianSub1618C=0.582T=0.418
The Genome Aggregation DatabaseEuropeSub18494C=0.152T=0.847
The Genome Aggregation DatabaseGlobalStudy-wide29956C=0.275T=0.725
The Genome Aggregation DatabaseOtherSub302C=0.140T=0.860
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.317T=0.682
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.156T=0.844
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs359522.21E-08alcohol dependence (age at onset)24962325

eQTL of rs35952 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs35952 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr55359219153592302E06728
chr55359230553592489E067142
chr55360474653604828E06712583
chr55359156353591979E068-184
chr55359219153592302E06828
chr55359230553592489E068142
chr55357394153574185E069-17978
chr55357422253574433E069-17730
chr55360335753603465E07011194
chr55360351753603786E07011354
chr55360440353604546E07012240
chr55360474653604828E07112583
chr55357394153574185E072-17978
chr55357422253574433E072-17730
chr55357444553574505E072-17658
chr55357422253574433E074-17730
chr55357444553574505E074-17658
chr55359119253591246E074-917
chr55359156353591979E074-184
chr55359219153592302E07428
chr55359230553592489E074142
chr55360351753603786E08111354
chr55360427953604329E08112116
chr55360440353604546E08112240
chr55360474653604828E08112583
chr55360803253608085E08115869








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr55360503053607991E06712867
chr55360503053607991E06812867
chr55360503053607991E06912867
chr55360503053607991E07012867
chr55355060653550896E071-41267
chr55360503053607991E07112867
chr55360503053607991E07212867
chr55360503053607991E07312867
chr55360503053607991E07412867
chr55360503053607991E08112867
chr55360503053607991E08212867