SNP Detail Info-rs3735273

Molecule type	Change	Amino acid[Codon]	SO Term
DDC transcript variant 2	NM_000790.3:c.	N/A	Intron Variant
DDC transcript variant 1	NM_001082971.1:c.	N/A	Intron Variant
DDC transcript variant 3	NM_001242886.1:c.	N/A	Intron Variant
DDC transcript variant 4	NM_001242887.1:c.	N/A	Intron Variant
DDC transcript variant 5	NM_001242888.1:c.	N/A	Intron Variant
DDC transcript variant 6	NM_001242889.1:c.	N/A	Intron Variant
DDC transcript variant 7	NM_001242890.1:c.	N/A	Intron Variant
DDC transcript variant X2	XM_005271745.4:c.	N/A	Intron Variant
DDC transcript variant X1	XM_011515161.2:c.	N/A	Intron Variant

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.625	T=0.375
1000Genomes	American	Sub	694	C=0.850	T=0.150
1000Genomes	East Asian	Sub	1008	C=0.608	T=0.392
1000Genomes	Europe	Sub	1006	C=0.772	T=0.228
1000Genomes	Global	Study-wide	5008	C=0.692	T=0.308
1000Genomes	South Asian	Sub	978	C=0.670	T=0.330
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.779	T=0.221
The Exome Aggregation Consortium	American	Sub	21980	C=0.772	T=0.227
The Exome Aggregation Consortium	Asian	Sub	25126	C=0.653	T=0.346
The Exome Aggregation Consortium	Europe	Sub	73314	C=0.764	T=0.235
The Exome Aggregation Consortium	Global	Study-wide	121328	C=0.742	T=0.257
The Exome Aggregation Consortium	Other	Sub	908	C=0.740	T=0.260
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.701	T=0.298
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.763	T=0.237

PMID	Title	Author	Journal
26044620	Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.	Reyes-Gibby CC	BMC Syst Biol
17184203	DOPA decarboxylase gene is associated with nicotine dependence.	Zhang H	Pharmacogenomics
15879433	Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.	Ma JZ	Hum Mol Genet

SNP ID	p-value	Traits	Study
rs3735273	0.001	Drug response to nicotine	15879433

eQTL of rs3735273 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr7:50596864	FIGNL1	ENSG00000132436.7	C>T	1.0000e-28	78776	Cerebellum
Chr7:50596864	FIGNL1	ENSG00000132436.7	C>T	4.8760e-13	78776	Cortex
Chr7:50596864	FIGNL1	ENSG00000132436.7	C>T	1.4382e-22	78776	Cerebellar_Hemisphere
Chr7:50596864	FIGNL1	ENSG00000132436.7	C>T	1.0286e-8	78776	Caudate_basal_ganglia
Chr7:50596864	FIGNL1	ENSG00000132436.7	C>T	5.5405e-6	78776	Hippocampus
Chr7:50596864	FIGNL1	ENSG00000132436.7	C>T	9.4277e-6	78776	Putamen_basal_ganglia

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr7	50598960	50599691	E067	2096
chr7	50599710	50599919	E067	2846
chr7	50599948	50600033	E067	3084
chr7	50600073	50600144	E067	3209
chr7	50602342	50602965	E068	5478
chr7	50599710	50599919	E069	2846
chr7	50599948	50600033	E069	3084
chr7	50600073	50600144	E069	3209
chr7	50595823	50595915	E070	-949
chr7	50595987	50596159	E070	-705
chr7	50598960	50599691	E070	2096
chr7	50600073	50600144	E070	3209
chr7	50623847	50624736	E070	26983
chr7	50624833	50625171	E070	27969
chr7	50625206	50625424	E070	28342
chr7	50625457	50625501	E070	28593
chr7	50628526	50629016	E070	31662
chr7	50628526	50629016	E071	31662
chr7	50628315	50628425	E074	31451
chr7	50628526	50629016	E074	31662
chr7	50598960	50599691	E081	2096
chr7	50599710	50599919	E081	2846
chr7	50599948	50600033	E081	3084
chr7	50628526	50629016	E082	31662

rs3735273