rs373905

Homo sapiens
C>T
LOC105378814 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0385 (11493/29850,GnomAD)
C==0438 (12761/29118,TOPMED)
C==0435 (2177/5008,1000G)
C==0330 (1270/3854,ALSPAC)
C==0341 (1266/3708,TWINSUK)
chr1:82647039 (GRCh38.p7) (1p31.1)
AD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.82647039C>T
GRCh37.p13 chr 1NC_000001.10:g.83112722C>T

Gene: LOC105378814, uncharacterized LOC105378814(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105378814 transcript variant X2XR_947533.2:n.N/AIntron Variant
LOC105378814 transcript variant X1XR_947532.2:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.535T=0.465
1000GenomesAmericanSub694C=0.380T=0.620
1000GenomesEast AsianSub1008C=0.480T=0.520
1000GenomesEuropeSub1006C=0.383T=0.617
1000GenomesGlobalStudy-wide5008C=0.435T=0.565
1000GenomesSouth AsianSub978C=0.340T=0.660
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.330T=0.670
The Genome Aggregation DatabaseAfricanSub8688C=0.512T=0.488
The Genome Aggregation DatabaseAmericanSub838C=0.390T=0.610
The Genome Aggregation DatabaseEast AsianSub1572C=0.460T=0.540
The Genome Aggregation DatabaseEuropeSub18450C=0.318T=0.682
The Genome Aggregation DatabaseGlobalStudy-wide29850C=0.385T=0.615
The Genome Aggregation DatabaseOtherSub302C=0.440T=0.560
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.438T=0.561
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.341T=0.659
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs3739052.06E-05alcohol dependence21703634

eQTL of rs373905 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs373905 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr18307233483072540E070-40182
chr18307233483072540E081-40182