rs3746722

Homo sapiens
G>A
SIRPG : Synonymous Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0247 (10473/42368,ExAC)
G==0258 (7703/29830,GnomAD)
G==0235 (6864/29118,TOPMED)
A=0270 (3509/12994,GO-ESP)
G==0173 (864/5008,1000G)
G==0359 (1384/3854,ALSPAC)
G==0346 (1282/3708,TWINSUK)
chr20:1630293 (GRCh38.p7) (20p13)
ND
GWASdb2
1   publication(s)
See rs on genome
97 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.1630293G>A
GRCh37.p13 chr 20NC_000020.10:g.1610939G>A

Gene: SIRPG, signal regulatory protein gamma(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SIRPG transcript variant 1NM_018556.3:c.109...NM_018556.3:c.1095C>TS [TCC]> S [TCT]Coding Sequence Variant
signal-regulatory protein gamma isoform 1 precursorNP_061026.2:p.Ser...NP_061026.2:p.Ser365=S [Ser]> S [Ser]Synonymous Variant
SIRPG transcript variant 2NM_080816.2:c.444C>TS [TCC]> S [TCT]Coding Sequence Variant
signal-regulatory protein gamma isoform 2 precursorNP_543006.2:p.Ser...NP_543006.2:p.Ser148=S [Ser]> S [Ser]Synonymous Variant
SIRPG transcript variant 3NM_001039508.1:c....NM_001039508.1:c.762C>TS [TCC]> S [TCT]Coding Sequence Variant
signal-regulatory protein gamma isoform 3 precursorNP_001034597.1:p....NP_001034597.1:p.Ser254=S [Ser]> S [Ser]Synonymous Variant
SIRPG transcript variant X3XM_011529287.2:c.N/AGenic Downstream Transcript Variant
SIRPG transcript variant X1XM_011529286.2:c....XM_011529286.2:c.996C>TS [TCC]> S [TCT]Coding Sequence Variant
signal-regulatory protein gamma isoform X1XP_011527588.1:p....XP_011527588.1:p.Ser332=S [Ser]> S [Ser]Synonymous Variant
SIRPG transcript variant X2XM_005260749.3:c....XM_005260749.3:c.777C>TS [TCC]> S [TCT]Coding Sequence Variant
signal-regulatory protein gamma isoform X2XP_005260806.1:p....XP_005260806.1:p.Ser259=S [Ser]> S [Ser]Synonymous Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.063A=0.937
1000GenomesAmericanSub694G=0.220A=0.780
1000GenomesEast AsianSub1008G=0.137A=0.863
1000GenomesEuropeSub1006G=0.346A=0.654
1000GenomesGlobalStudy-wide5008G=0.173A=0.827
1000GenomesSouth AsianSub978G=0.140A=0.860
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.359A=0.641
The Exome Aggregation ConsortiumAmericanSub7458G=0.143A=0.857
The Exome Aggregation ConsortiumAsianSub11986G=0.165A=0.834
The Exome Aggregation ConsortiumEuropeSub22602G=0.324A=0.675
The Exome Aggregation ConsortiumGlobalStudy-wide42368G=0.247A=0.752
The Exome Aggregation ConsortiumOtherSub322G=0.280A=0.720
The Genome Aggregation DatabaseAfricanSub8696G=0.109A=0.891
The Genome Aggregation DatabaseAmericanSub834G=0.230A=0.770
The Genome Aggregation DatabaseEast AsianSub1602G=0.181A=0.819
The Genome Aggregation DatabaseEuropeSub18398G=0.336A=0.663
The Genome Aggregation DatabaseGlobalStudy-wide29830G=0.258A=0.741
The Genome Aggregation DatabaseOtherSub300G=0.230A=0.770
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.235A=0.764
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.346A=0.654
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs37467224.57E-05alcohol and nictotine co-dependence20158304

eQTL of rs3746722 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3746722 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2016525631652604E06741624
chr2016527041652813E06741765
chr2016528491652920E06741910
chr2016530511653261E06742112
chr2016533841653564E06742445
chr2016536731653713E06742734
chr2016537411653875E06742802
chr2016541131654167E06743174
chr2016542181654310E06743279
chr2016543651654449E06743426
chr2016545491654665E06743610
chr2016518571651942E06840918
chr2016530511653261E06842112
chr2016533841653564E06842445
chr2016536731653713E06842734
chr2016537411653875E06842802
chr2016541131654167E06843174
chr2016542181654310E06843279
chr2016543651654449E06843426
chr2016545491654665E06843610
chr2016567151656756E06845776
chr2016569281656978E06845989
chr2016520001652064E06941061
chr2016525631652604E06941624
chr2016527041652813E06941765
chr2016528491652920E06941910
chr2016530511653261E06942112
chr2016533841653564E06942445
chr2016536731653713E06942734
chr2016537411653875E06942802
chr2016541131654167E06943174
chr2016542181654310E06943279
chr2016543651654449E06943426
chr2016545491654665E06943610
chr2016549601655094E06944021
chr2016558711656076E06944932
chr2016562221656284E06945283
chr2016564341656474E06945495
chr2016567151656756E06945776
chr2016043381604409E071-6530
chr2016045671604748E071-6191
chr2016518571651942E07140918
chr2016520001652064E07141061
chr2016525631652604E07141624
chr2016527041652813E07141765
chr2016528491652920E07141910
chr2016530511653261E07142112
chr2016533841653564E07142445
chr2016536731653713E07142734
chr2016537411653875E07142802
chr2016541131654167E07143174
chr2016542181654310E07143279
chr2016543651654449E07143426
chr2016567151656756E07145776
chr2016500841650217E07239145
chr2016502761650319E07239337
chr2016518571651942E07240918
chr2016525631652604E07241624
chr2016527041652813E07241765
chr2016530511653261E07242112
chr2016533841653564E07242445
chr2016536731653713E07242734
chr2016537411653875E07242802
chr2016541131654167E07243174
chr2016542181654310E07243279
chr2016543651654449E07243426
chr2016545491654665E07243610
chr2016549601655094E07244021
chr2016558711656076E07244932
chr2016562221656284E07245283
chr2016564341656474E07245495
chr2016567151656756E07245776
chr2016516211651771E07340682
chr2016562221656284E07345283
chr2016564341656474E07345495
chr2016567151656756E07345776
chr2016569281656978E07345989
chr2016575411657595E07346602
chr2016495451649662E07438606
chr2016520001652064E07441061
chr2016525631652604E07441624
chr2016527041652813E07441765
chr2016528491652920E07441910
chr2016530511653261E07442112
chr2016533841653564E07442445
chr2016536731653713E07442734
chr2016537411653875E07442802
chr2016541131654167E07443174
chr2016542181654310E07443279
chr2016543651654449E07443426
chr2016545491654665E07443610
chr2016549601655094E07444021
chr2016567151656756E07445776
chr2016569281656978E07445989
chr2016026311602730E081-8209
chr2016030661603120E081-7819
chr2016031371603441E081-7498