rs376096

Homo sapiens
T>C
LOC105377876 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0103 (3004/29118,TOPMED)
T==0092 (2636/28632,GnomAD)
T==0079 (395/5008,1000G)
T==0123 (474/3854,ALSPAC)
T==0128 (473/3708,TWINSUK)
chr6:82660735 (GRCh38.p7) (6q14.1)
ND
GWASdb2
1   publication(s)
See rs on genome
12 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.82660735T>C
GRCh37.p13 chr 6NC_000006.11:g.83370452T>C

Gene: LOC105377876, uncharacterized LOC105377876(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105377876 transcript variant X1XR_001744232.1:n.N/AIntron Variant
LOC105377876 transcript variant X2XR_942739.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.072C=0.928
1000GenomesAmericanSub694T=0.140C=0.860
1000GenomesEast AsianSub1008T=0.007C=0.993
1000GenomesEuropeSub1006T=0.118C=0.882
1000GenomesGlobalStudy-wide5008T=0.079C=0.921
1000GenomesSouth AsianSub978T=0.080C=0.920
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.123C=0.877
The Genome Aggregation DatabaseAfricanSub8462T=0.078C=0.922
The Genome Aggregation DatabaseAmericanSub802T=0.140C=0.860
The Genome Aggregation DatabaseEast AsianSub1570T=0.003C=0.997
The Genome Aggregation DatabaseEuropeSub17502T=0.104C=0.895
The Genome Aggregation DatabaseGlobalStudy-wide28632T=0.092C=0.907
The Genome Aggregation DatabaseOtherSub296T=0.110C=0.890
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.103C=0.896
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.128C=0.872
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs3760964.04E-05alcohol and nictotine co-dependence20158304

eQTL of rs376096 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs376096 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr68332225483322682E067-47770
chr68332206583322121E069-48331
chr68332225483322682E069-47770
chr68332225483322682E070-47770
chr68332165283321800E071-48652
chr68332206583322121E071-48331
chr68332225483322682E071-47770
chr68332225483322682E072-47770
chr68332165283321800E074-48652
chr68332206583322121E074-48331
chr68332225483322682E074-47770
chr68340281483403082E08132362