rs3774084

Homo sapiens
T>C
SLC6A11 : Intron Variant
LOC105376950 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0262 (7862/29912,GnomAD)
C=0217 (6318/29118,TOPMED)
C=0159 (798/5008,1000G)
C=0353 (1361/3854,ALSPAC)
C=0352 (1306/3708,TWINSUK)
chr3:10916591 (GRCh38.p7) (3p25.3)
AD
GWASdb2
1   publication(s)
See rs on genome
194 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.10916591T>C
GRCh37.p13 chr 3NC_000003.11:g.10958276T>C

Gene: SLC6A11, solute carrier family 6 member 11(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC6A11 transcript variant 1NM_014229.2:c.N/AIntron Variant
SLC6A11 transcript variant 2NM_001317406.1:c.N/AGenic Downstream Transcript Variant
SLC6A11 transcript variant X2XM_011534033.2:c.N/AIntron Variant
SLC6A11 transcript variant X1XM_017007073.1:c.N/AIntron Variant

Gene: LOC105376950, uncharacterized LOC105376950(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376950 transcriptXR_940587.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.986C=0.014
1000GenomesAmericanSub694T=0.810C=0.190
1000GenomesEast AsianSub1008T=0.874C=0.126
1000GenomesEuropeSub1006T=0.627C=0.373
1000GenomesGlobalStudy-wide5008T=0.841C=0.159
1000GenomesSouth AsianSub978T=0.850C=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.647C=0.353
The Genome Aggregation DatabaseAfricanSub8708T=0.935C=0.065
The Genome Aggregation DatabaseAmericanSub834T=0.800C=0.200
The Genome Aggregation DatabaseEast AsianSub1618T=0.883C=0.117
The Genome Aggregation DatabaseEuropeSub18450T=0.629C=0.370
The Genome Aggregation DatabaseGlobalStudy-wide29912T=0.737C=0.262
The Genome Aggregation DatabaseOtherSub302T=0.640C=0.360
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.783C=0.217
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.648C=0.352
PMID Title Author Journal
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.Zuo LPLoS One

P-Value

SNP ID p-value Traits Study
rs37740846.5E-06alcohol dependence22096494

eQTL of rs3774084 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3774084 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr31098729410987392E06729018
chr31098744710987821E06729171
chr31099000110990055E06731725
chr31099026910990402E06731993
chr31099041610990484E06732140
chr31099086110991325E06732585
chr31099172310991785E06733447
chr31099262610992807E06734350
chr31099736910997474E06739093
chr31099748110997678E06739205
chr31099789310998069E06739617
chr31099819110998291E06739915
chr31099848610999167E06740210
chr31099934610999407E06741070
chr31099945210999925E06741176
chr31100011111000360E06741835
chr31094284810942993E068-15283
chr31097026710970395E06811991
chr31098388110983979E06825605
chr31098744710987821E06829171
chr31098814410988547E06829868
chr31099000110990055E06831725
chr31099026910990402E06831993
chr31099041610990484E06832140
chr31099086110991325E06832585
chr31099172310991785E06833447
chr31099262610992807E06834350
chr31099540710995457E06837131
chr31099736910997474E06839093
chr31099748110997678E06839205
chr31099789310998069E06839617
chr31099819110998291E06839915
chr31099848610999167E06840210
chr31099934610999407E06841070
chr31099945210999925E06841176
chr31100011111000360E06841835
chr31100381111003861E06845535
chr31096831710968532E06910041
chr31097788810978021E06919612
chr31098744710987821E06929171
chr31098814410988547E06929868
chr31098861310988693E06930337
chr31098878010988850E06930504
chr31099000110990055E06931725
chr31099026910990402E06931993
chr31099041610990484E06932140
chr31099086110991325E06932585
chr31099172310991785E06933447
chr31099262610992807E06934350
chr31099748110997678E06939205
chr31099789310998069E06939617
chr31099819110998291E06939915
chr31099848610999167E06940210
chr31099934610999407E06941070
chr31099945210999925E06941176
chr31100011111000360E06941835
chr31091120110911455E070-46821
chr31094305010944015E070-14261
chr31096831710968532E07010041
chr31096874710968947E07010471
chr31096903110969176E07010755
chr31096937610969468E07011100
chr31097026710970395E07011991
chr31097217610972417E07013900
chr31097261810972692E07014342
chr31097788810978021E07019612
chr31098729410987392E07029018
chr31098814410988547E07029868
chr31098861310988693E07030337
chr31098878010988850E07030504
chr31099000110990055E07031725
chr31099026910990402E07031993
chr31099041610990484E07032140
chr31099086110991325E07032585
chr31099172310991785E07033447
chr31099262610992807E07034350
chr31099436510994463E07036089
chr31099540710995457E07037131
chr31099736910997474E07039093
chr31099748110997678E07039205
chr31099789310998069E07039617
chr31099819110998291E07039915
chr31099848610999167E07040210
chr31099934610999407E07041070
chr31099945210999925E07041176
chr31100011111000360E07041835
chr31100381111003861E07045535
chr31100428111004389E07046005
chr31100634411006579E07048068
chr31100662411006689E07048348
chr31096874710968947E07110471
chr31096903110969176E07110755
chr31096937610969468E07111100
chr31097606810976167E07117792
chr31097623510976285E07117959
chr31098450010984697E07126224
chr31098861310988693E07130337
chr31098878010988850E07130504
chr31099000110990055E07131725
chr31099026910990402E07131993
chr31099041610990484E07132140
chr31099086110991325E07132585
chr31099172310991785E07133447
chr31099262610992807E07134350
chr31099736910997474E07139093
chr31099748110997678E07139205
chr31099789310998069E07139617
chr31099819110998291E07139915
chr31099848610999167E07140210
chr31099934610999407E07141070
chr31099945210999925E07141176
chr31100011111000360E07141835
chr31098744710987821E07229171
chr31098814410988547E07229868
chr31098861310988693E07230337
chr31098878010988850E07230504
chr31099000110990055E07231725
chr31099026910990402E07231993
chr31099041610990484E07232140
chr31099086110991325E07232585
chr31099172310991785E07233447
chr31099262610992807E07234350
chr31099540710995457E07237131
chr31099736910997474E07239093
chr31099748110997678E07239205
chr31099789310998069E07239617
chr31099819110998291E07239915
chr31099848610999167E07240210
chr31099934610999407E07241070
chr31099945210999925E07241176
chr31100011111000360E07241835
chr31097543310975839E07317157
chr31098388110983979E07325605
chr31098861310988693E07330337
chr31098878010988850E07330504
chr31099000110990055E07331725
chr31099026910990402E07331993
chr31099041610990484E07332140
chr31099086110991325E07332585
chr31099172310991785E07333447
chr31099262610992807E07334350
chr31099436510994463E07336089
chr31099540710995457E07337131
chr31099736910997474E07339093
chr31099748110997678E07339205
chr31099789310998069E07339617
chr31099819110998291E07339915
chr31099848610999167E07340210
chr31099934610999407E07341070
chr31099945210999925E07341176
chr31100011111000360E07341835
chr31098744710987821E07429171
chr31098814410988547E07429868
chr31098861310988693E07430337
chr31098878010988850E07430504
chr31099000110990055E07431725
chr31099026910990402E07431993
chr31099041610990484E07432140
chr31099086110991325E07432585
chr31099172310991785E07433447
chr31099736910997474E07439093
chr31099748110997678E07439205
chr31099789310998069E07439617
chr31099819110998291E07439915
chr31099848610999167E07440210
chr31099934610999407E07441070
chr31099945210999925E07441176
chr31100011111000360E07441835
chr31096831710968532E08110041
chr31096874710968947E08110471
chr31096903110969176E08110755
chr31096937610969468E08111100
chr31097026710970395E08111991
chr31097217610972417E08113900
chr31097261810972692E08114342
chr31097606810976167E08117792
chr31097623510976285E08117959
chr31099026910990402E08131993
chr31099041610990484E08132140
chr31099086110991325E08132585
chr31099172310991785E08133447
chr31099262610992807E08134350
chr31099748110997678E08139205
chr31099789310998069E08139617
chr31100011111000360E08141835
chr31096831710968532E08210041
chr31096874710968947E08210471
chr31097606810976167E08217792
chr31099086110991325E08232585
chr31099262610992807E08234350
chr31099436510994463E08236089
chr31099934610999407E08241070
chr31099945210999925E08241176
chr31100011111000360E08241835