rs3774391

Homo sapiens
C>T
TRAK1 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0289 (8649/29836,GnomAD)
T=0224 (6544/29118,TOPMED)
T=0237 (1186/5008,1000G)
T=0350 (1347/3854,ALSPAC)
T=0338 (1253/3708,TWINSUK)
chr3:42223877 (GRCh38.p7) (3p22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
217 Enhancers around
12 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.42223877C>T
GRCh37.p13 chr 3NC_000003.11:g.42265369C>T

Gene: TRAK1, trafficking protein, kinesin binding 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TRAK1 transcript variant 1NM_001042646.2:c.N/A3 Prime UTR Variant
TRAK1 transcript variant 3NM_001265608.1:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant 4NM_001265609.1:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant 5NM_001265610.1:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant 2NM_014965.4:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X2XM_005264956.2:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X6XM_005264958.2:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X2XM_017005906.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X3XM_017005907.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X7XM_017005908.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X8XM_017005909.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X7XM_017005910.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X9XM_017005911.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X10XM_005264960.3:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X12XM_017005913.1:c.N/A3 Prime UTR Variant
TRAK1 transcript variant X14XM_005264962.3:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X17XM_005264963.3:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X15XM_006713029.2:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X18XM_006713030.2:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X19XM_006713031.3:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X16XM_011533489.2:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X9XM_017005912.1:c.N/AGenic Downstream Transcript Variant
TRAK1 transcript variant X11XR_001740058.1:n....XR_001740058.1:n.3200C>TC>TNon Coding Transcript Variant
TRAK1 transcript variant X13XR_001740059.1:n....XR_001740059.1:n.3137C>TC>TNon Coding Transcript Variant
TRAK1 transcript variant X20XR_001740060.1:n....XR_001740060.1:n.3635C>TC>TNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.919T=0.081
1000GenomesAmericanSub694C=0.790T=0.210
1000GenomesEast AsianSub1008C=0.654T=0.346
1000GenomesEuropeSub1006C=0.630T=0.370
1000GenomesGlobalStudy-wide5008C=0.763T=0.237
1000GenomesSouth AsianSub978C=0.780T=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.650T=0.350
The Genome Aggregation DatabaseAfricanSub8706C=0.885T=0.115
The Genome Aggregation DatabaseAmericanSub836C=0.800T=0.200
The Genome Aggregation DatabaseEast AsianSub1610C=0.650T=0.350
The Genome Aggregation DatabaseEuropeSub18384C=0.629T=0.370
The Genome Aggregation DatabaseGlobalStudy-wide29836C=0.710T=0.289
The Genome Aggregation DatabaseOtherSub300C=0.660T=0.340
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.775T=0.224
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.662T=0.338
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs37743910.00087alcohol dependence20201924

eQTL of rs3774391 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3774391 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr34221672942216790E067-48579
chr34221816542218399E067-46970
chr34221896342219013E067-46356
chr34221906042219221E067-46148
chr34221932742219397E067-45972
chr34221970542219755E067-45614
chr34221975842219969E067-45400
chr34222052742221292E067-44077
chr34222149442221549E067-43820
chr34222527942225380E067-39989
chr34222564442225764E067-39605
chr34222577942226155E067-39214
chr34222623542226415E067-38954
chr34222655242226944E067-38425
chr34223246342233216E067-32153
chr34223399942234336E067-31033
chr34223700142237079E067-28290
chr34223761542237684E067-27685
chr34223771542237821E067-27548
chr34225532842255821E067-9548
chr34225696942257059E067-8310
chr34225706342257113E067-8256
chr34227125742271379E0675888
chr34227145142271715E0676082
chr34221672942216790E068-48579
chr34221719242217933E068-47436
chr34221816542218399E068-46970
chr34221896342219013E068-46356
chr34221906042219221E068-46148
chr34221932742219397E068-45972
chr34221970542219755E068-45614
chr34221975842219969E068-45400
chr34222052742221292E068-44077
chr34222149442221549E068-43820
chr34222507842225194E068-40175
chr34222527942225380E068-39989
chr34222564442225764E068-39605
chr34222577942226155E068-39214
chr34222623542226415E068-38954
chr34222655242226944E068-38425
chr34222984742229959E068-35410
chr34222996142230154E068-35215
chr34223246342233216E068-32153
chr34223700142237079E068-28290
chr34223761542237684E068-27685
chr34223771542237821E068-27548
chr34225591742256036E068-9333
chr34225619142256340E068-9029
chr34225647842256646E068-8723
chr34225696942257059E068-8310
chr34225706342257113E068-8256
chr34226576042265951E068391
chr34226628542266376E068916
chr34227125742271379E0685888
chr34227145142271715E0686082
chr34227243842272582E0687069
chr34228891642289557E06823547
chr34228957642289708E06824207
chr34221672942216790E069-48579
chr34221719242217933E069-47436
chr34221816542218399E069-46970
chr34221896342219013E069-46356
chr34221906042219221E069-46148
chr34221932742219397E069-45972
chr34221970542219755E069-45614
chr34221975842219969E069-45400
chr34222052742221292E069-44077
chr34222507842225194E069-40175
chr34222527942225380E069-39989
chr34222564442225764E069-39605
chr34222577942226155E069-39214
chr34222623542226415E069-38954
chr34222655242226944E069-38425
chr34222958542229688E069-35681
chr34223173442231784E069-33585
chr34223198542232084E069-33285
chr34223219242232242E069-33127
chr34223246342233216E069-32153
chr34223399942234336E069-31033
chr34223441942234639E069-30730
chr34226562342265673E069254
chr34226576042265951E069391
chr34226628542266376E069916
chr34226655642266865E0691187
chr34227125742271379E0695888
chr34227145142271715E0696082
chr34228957642289708E06924207
chr34221703742217121E070-48248
chr34221719242217933E070-47436
chr34222507842225194E070-40175
chr34222527942225380E070-39989
chr34222564442225764E070-39605
chr34222577942226155E070-39214
chr34222623542226415E070-38954
chr34222655242226944E070-38425
chr34227145142271715E0706082
chr34221672942216790E071-48579
chr34221816542218399E071-46970
chr34221896342219013E071-46356
chr34221906042219221E071-46148
chr34221932742219397E071-45972
chr34221970542219755E071-45614
chr34221975842219969E071-45400
chr34222052742221292E071-44077
chr34222149442221549E071-43820
chr34222507842225194E071-40175
chr34222527942225380E071-39989
chr34222564442225764E071-39605
chr34222577942226155E071-39214
chr34222623542226415E071-38954
chr34222655242226944E071-38425
chr34223134142231560E071-33809
chr34223173442231784E071-33585
chr34223198542232084E071-33285
chr34223219242232242E071-33127
chr34223246342233216E071-32153
chr34223441942234639E071-30730
chr34227125742271379E0715888
chr34227145142271715E0716082
chr34221672942216790E072-48579
chr34221816542218399E072-46970
chr34221896342219013E072-46356
chr34221906042219221E072-46148
chr34221932742219397E072-45972
chr34222052742221292E072-44077
chr34222418142224304E072-41065
chr34222507842225194E072-40175
chr34222527942225380E072-39989
chr34222564442225764E072-39605
chr34222577942226155E072-39214
chr34222623542226415E072-38954
chr34222655242226944E072-38425
chr34223028542231006E072-34363
chr34223198542232084E072-33285
chr34223219242232242E072-33127
chr34223246342233216E072-32153
chr34223441942234639E072-30730
chr34225495442255266E072-10103
chr34225532842255821E072-9548
chr34225591742256036E072-9333
chr34225619142256340E072-9029
chr34225647842256646E072-8723
chr34226562342265673E072254
chr34226576042265951E072391
chr34226628542266376E072916
chr34226655642266865E0721187
chr34227145142271715E0726082
chr34221549842215548E073-49821
chr34221703742217121E073-48248
chr34221719242217933E073-47436
chr34221816542218399E073-46970
chr34221896342219013E073-46356
chr34221906042219221E073-46148
chr34221932742219397E073-45972
chr34221970542219755E073-45614
chr34221975842219969E073-45400
chr34222052742221292E073-44077
chr34222527942225380E073-39989
chr34222564442225764E073-39605
chr34222577942226155E073-39214
chr34222623542226415E073-38954
chr34222655242226944E073-38425
chr34222958542229688E073-35681
chr34222984742229959E073-35410
chr34222996142230154E073-35215
chr34223028542231006E073-34363
chr34223134142231560E073-33809
chr34223173442231784E073-33585
chr34223198542232084E073-33285
chr34223219242232242E073-33127
chr34223246342233216E073-32153
chr34223441942234639E073-30730
chr34223700142237079E073-28290
chr34226214542262263E073-3106
chr34226628542266376E073916
chr34227125742271379E0735888
chr34227145142271715E0736082
chr34227243842272582E0737069
chr34221672942216790E074-48579
chr34221719242217933E074-47436
chr34221816542218399E074-46970
chr34221896342219013E074-46356
chr34221906042219221E074-46148
chr34221932742219397E074-45972
chr34221970542219755E074-45614
chr34221975842219969E074-45400
chr34222052742221292E074-44077
chr34222242842222675E074-42694
chr34222301042223218E074-42151
chr34222418142224304E074-41065
chr34222507842225194E074-40175
chr34222527942225380E074-39989
chr34222564442225764E074-39605
chr34222577942226155E074-39214
chr34222623542226415E074-38954
chr34222655242226944E074-38425
chr34223028542231006E074-34363
chr34223173442231784E074-33585
chr34223198542232084E074-33285
chr34223219242232242E074-33127
chr34223246342233216E074-32153
chr34223399942234336E074-31033
chr34223441942234639E074-30730
chr34225481942254869E074-10500
chr34225495442255266E074-10103
chr34226214542262263E074-3106
chr34227125742271379E0745888
chr34227125742271379E0815888
chr34222052742221292E082-44077
chr34222527942225380E082-39989
chr34222564442225764E082-39605
chr34222577942226155E082-39214
chr34222623542226415E082-38954
chr34222655242226944E082-38425
chr34223198542232084E082-33285
chr34223219242232242E082-33127
chr34227145142271715E0826082










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr34230473842305209E06739369
chr34230521842305292E06739849
chr34230535542305490E06739986
chr34230473842305209E06839369
chr34230521842305292E06839849
chr34230535542305490E06839986
chr34230473842305209E07239369
chr34230521842305292E07239849
chr34230535542305490E07239986
chr34230473842305209E07339369
chr34230521842305292E07339849
chr34230535542305490E07339986