rs3776641

Homo sapiens
C>T
ARL15 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0382 (11464/29942,GnomAD)
C==0414 (12077/29118,TOPMED)
C==0463 (2318/5008,1000G)
C==0313 (1208/3854,ALSPAC)
C==0308 (1143/3708,TWINSUK)
chr5:54286422 (GRCh38.p7) (5q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.54286422C>T
GRCh37.p13 chr 5NC_000005.9:g.53582252C>T

Gene: ARL15, ADP ribosylation factor like GTPase 15(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL15 transcriptNM_019087.2:c.N/AIntron Variant
ARL15 transcript variant X1XM_011543498.2:c.N/AIntron Variant
ARL15 transcript variant X2XM_011543499.2:c.N/AIntron Variant
ARL15 transcript variant X3XM_011543500.2:c.N/AIntron Variant
ARL15 transcript variant X4XM_017009598.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.524T=0.476
1000GenomesAmericanSub694C=0.540T=0.460
1000GenomesEast AsianSub1008C=0.577T=0.423
1000GenomesEuropeSub1006C=0.317T=0.683
1000GenomesGlobalStudy-wide5008C=0.463T=0.537
1000GenomesSouth AsianSub978C=0.360T=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.313T=0.687
The Genome Aggregation DatabaseAfricanSub8712C=0.502T=0.498
The Genome Aggregation DatabaseAmericanSub828C=0.530T=0.470
The Genome Aggregation DatabaseEast AsianSub1616C=0.608T=0.392
The Genome Aggregation DatabaseEuropeSub18484C=0.302T=0.697
The Genome Aggregation DatabaseGlobalStudy-wide29942C=0.382T=0.617
The Genome Aggregation DatabaseOtherSub302C=0.240T=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.414T=0.585
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.308T=0.692
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs37766419.42E-07alcohol dependence (age at onset)24962325

eQTL of rs3776641 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3776641 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr55359219153592302E0679939
chr55359230553592489E06710053
chr55360474653604828E06722494
chr55359156353591979E0689311
chr55359219153592302E0689939
chr55359230553592489E06810053
chr55357394153574185E069-8067
chr55357422253574433E069-7819
chr55360335753603465E07021105
chr55360351753603786E07021265
chr55360440353604546E07022151
chr55360474653604828E07122494
chr55357394153574185E072-8067
chr55357422253574433E072-7819
chr55357444553574505E072-7747
chr55357422253574433E074-7819
chr55357444553574505E074-7747
chr55359119253591246E0748940
chr55359156353591979E0749311
chr55359219153592302E0749939
chr55359230553592489E07410053
chr55360351753603786E08121265
chr55360427953604329E08122027
chr55360440353604546E08122151
chr55360474653604828E08122494
chr55360803253608085E08125780








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr55360503053607991E06722778
chr55360503053607991E06822778
chr55360503053607991E06922778
chr55360503053607991E07022778
chr55355060653550896E071-31356
chr55360503053607991E07122778
chr55360503053607991E07222778
chr55360503053607991E07322778
chr55360503053607991E07422778
chr55360503053607991E08122778
chr55360503053607991E08222778