rs3776642

Homo sapiens
T>G
ARL15 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0382 (11444/29920,GnomAD)
T==0414 (12066/29118,TOPMED)
T==0463 (2317/5008,1000G)
T==0314 (1209/3854,ALSPAC)
T==0307 (1140/3708,TWINSUK)
chr5:54286396 (GRCh38.p7) (5q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.54286396T>G
GRCh37.p13 chr 5NC_000005.9:g.53582226T>G

Gene: ARL15, ADP ribosylation factor like GTPase 15(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL15 transcriptNM_019087.2:c.N/AIntron Variant
ARL15 transcript variant X1XM_011543498.2:c.N/AIntron Variant
ARL15 transcript variant X2XM_011543499.2:c.N/AIntron Variant
ARL15 transcript variant X3XM_011543500.2:c.N/AIntron Variant
ARL15 transcript variant X4XM_017009598.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.524G=0.476
1000GenomesAmericanSub694T=0.540G=0.460
1000GenomesEast AsianSub1008T=0.577G=0.423
1000GenomesEuropeSub1006T=0.316G=0.684
1000GenomesGlobalStudy-wide5008T=0.463G=0.537
1000GenomesSouth AsianSub978T=0.360G=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.314G=0.686
The Genome Aggregation DatabaseAfricanSub8704T=0.502G=0.498
The Genome Aggregation DatabaseAmericanSub832T=0.530G=0.470
The Genome Aggregation DatabaseEast AsianSub1614T=0.608G=0.392
The Genome Aggregation DatabaseEuropeSub18468T=0.302G=0.698
The Genome Aggregation DatabaseGlobalStudy-wide29920T=0.382G=0.617
The Genome Aggregation DatabaseOtherSub302T=0.240G=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.414G=0.585
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.307G=0.693
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs37766425.52E-07alcohol dependence (age at onset)24962325

eQTL of rs3776642 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3776642 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr55359219153592302E0679965
chr55359230553592489E06710079
chr55360474653604828E06722520
chr55359156353591979E0689337
chr55359219153592302E0689965
chr55359230553592489E06810079
chr55357394153574185E069-8041
chr55357422253574433E069-7793
chr55360335753603465E07021131
chr55360351753603786E07021291
chr55360440353604546E07022177
chr55360474653604828E07122520
chr55357394153574185E072-8041
chr55357422253574433E072-7793
chr55357444553574505E072-7721
chr55357422253574433E074-7793
chr55357444553574505E074-7721
chr55359119253591246E0748966
chr55359156353591979E0749337
chr55359219153592302E0749965
chr55359230553592489E07410079
chr55360351753603786E08121291
chr55360427953604329E08122053
chr55360440353604546E08122177
chr55360474653604828E08122520
chr55360803253608085E08125806








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr55360503053607991E06722804
chr55360503053607991E06822804
chr55360503053607991E06922804
chr55360503053607991E07022804
chr55355060653550896E071-31330
chr55360503053607991E07122804
chr55360503053607991E07222804
chr55360503053607991E07322804
chr55360503053607991E07422804
chr55360503053607991E08122804
chr55360503053607991E08222804