rs3803476

Homo sapiens
A>G
IGF1R : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0366 (10972/29914,GnomAD)
A==0372 (10834/29118,TOPMED)
A==0385 (1927/5008,1000G)
A==0386 (1489/3854,ALSPAC)
A==0382 (1416/3708,TWINSUK)
chr15:98713341 (GRCh38.p7) (15q26.3)
AD
GWASdb2
2   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.98713341A>G
GRCh37.p13 chr 15NC_000015.9:g.99256570A>G
IGF1R RefSeqGeneNG_009492.1:g.68810A>G

Gene: IGF1R, insulin like growth factor 1 receptor(plus strand)

Molecule type Change Amino acid[Codon] SO Term
IGF1R transcript variant 1NM_000875.4:c.N/AIntron Variant
IGF1R transcript variant 2NM_001291858.1:c.N/AIntron Variant
IGF1R transcript variant X1XM_017022136.1:c.N/AIntron Variant
IGF1R transcript variant X2XM_017022137.1:c.N/AIntron Variant
IGF1R transcript variant X3XM_017022138.1:c.N/AIntron Variant
IGF1R transcript variant X4XM_017022139.1:c.N/AIntron Variant
IGF1R transcript variant X6XM_011521516.2:c.N/AGenic Upstream Transcript Variant
IGF1R transcript variant X7XM_011521517.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.272G=0.728
1000GenomesAmericanSub694A=0.450G=0.550
1000GenomesEast AsianSub1008A=0.434G=0.566
1000GenomesEuropeSub1006A=0.372G=0.628
1000GenomesGlobalStudy-wide5008A=0.385G=0.615
1000GenomesSouth AsianSub978A=0.460G=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.386G=0.614
The Genome Aggregation DatabaseAfricanSub8714A=0.296G=0.704
The Genome Aggregation DatabaseAmericanSub836A=0.460G=0.540
The Genome Aggregation DatabaseEast AsianSub1616A=0.441G=0.559
The Genome Aggregation DatabaseEuropeSub18448A=0.388G=0.611
The Genome Aggregation DatabaseGlobalStudy-wide29914A=0.366G=0.633
The Genome Aggregation DatabaseOtherSub300A=0.440G=0.560
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.372G=0.627
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.382G=0.618
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
26962151Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.Verweij NHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs38034760.00032alcohol dependence20201924

eQTL of rs3803476 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3803476 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr159920892099209224E067-47346
chr159920928299209346E067-47224
chr159921054399211433E067-45137
chr159921143499212687E067-43883
chr159921271299213080E067-43490
chr159921332699213380E067-43190
chr159921340999213610E067-42960
chr159921375999213823E067-42747
chr159921387399214017E067-42553
chr159921401899214098E067-42472
chr159921410199215478E067-41092
chr159921636599216513E067-40057
chr159921659299217206E067-39364
chr159921720899217937E067-38633
chr159922069699221203E067-35367
chr159922618699226305E067-30265
chr159922631099228127E067-28443
chr159923031699230727E067-25843
chr159923608399236146E067-20424
chr159923621599236825E067-19745
chr159923710899237211E067-19359
chr159923803699238308E067-18262
chr159923845599238667E067-17903
chr159923872499239601E067-16969
chr159924183799242185E067-14385
chr159924222699243061E067-13509
chr159924309999243254E067-13316
chr159924338399243553E067-13017
chr159924355799243607E067-12963
chr159924367199243711E067-12859
chr159924378599243898E067-12672
chr159924390099244066E067-12504
chr159924419099244274E067-12296
chr159924603399246085E067-10485
chr159924626199246310E067-10260
chr159924633399246428E067-10142
chr159924769199248629E067-7941
chr159924878899248998E067-7572
chr159925114699251249E067-5321
chr159925141699251992E067-4578
chr159925615099257583E0670
chr159925801299258107E0671442
chr159925816499258560E0671594
chr159925880699259957E0672236
chr159926000299260318E0673432
chr159926034799260481E0673777
chr159926056699260775E0673996
chr159926081299260913E0674242
chr159926104199261160E0674471
chr159926116699261376E0674596
chr159926141899261641E0674848
chr159926172999263007E0675159
chr159926306999263124E0676499
chr159926313099263381E0676560
chr159926344499264219E0676874
chr159926425999264398E0677689
chr159926444899264498E0677878
chr159926450999264679E0677939
chr159926474799264892E0678177
chr159927050999271871E06713939
chr159927187399272431E06715303
chr159927254599272679E06715975
chr159927273599273542E06716165
chr159927442499274741E06717854
chr159927477599274948E06718205
chr159927497299275178E06718402
chr159927522199275478E06718651
chr159927555299275983E06718982
chr159929477499294824E06738204
chr159929504799295368E06738477
chr159929543599295534E06738865
chr159929700299298214E06740432
chr159930151599301824E06744945
chr159930185499301950E06745284
chr159930217999302229E06745609
chr159930227999302539E06745709
chr159930346099304223E06746890
chr159930429299304494E06747722
chr159930451799304697E06747947
chr159930480199304884E06748231
chr159930490199304984E06748331
chr159930506299305227E06748492
chr159920677799206921E068-49649
chr159920696299207254E068-49316
chr159920737299207416E068-49154
chr159920854099208819E068-47751
chr159920892099209224E068-47346
chr159920928299209346E068-47224
chr159920940999209469E068-47101
chr159921143499212687E068-43883
chr159921271299213080E068-43490
chr159921332699213380E068-43190
chr159921340999213610E068-42960
chr159921375999213823E068-42747
chr159921387399214017E068-42553
chr159921401899214098E068-42472
chr159921410199215478E068-41092
chr159921636599216513E068-40057
chr159921659299217206E068-39364
chr159922460199224723E068-31847
chr159922484999224923E068-31647
chr159922524199225553E068-31017
chr159922572499225817E068-30753
chr159922583899225926E068-30644
chr159922618699226305E068-30265
chr159922631099228127E068-28443
chr159923031699230727E068-25843
chr159923103199231834E068-24736
chr159923621599236825E068-19745
chr159923722399237288E068-19282
chr159924183799242185E068-14385
chr159924222699243061E068-13509
chr159924309999243254E068-13316
chr159924338399243553E068-13017
chr159924355799243607E068-12963
chr159924367199243711E068-12859
chr159924378599243898E068-12672
chr159924390099244066E068-12504
chr159924626199246310E068-10260
chr159924633399246428E068-10142
chr159924647599246862E068-9708
chr159924688699246995E068-9575
chr159925020299250715E068-5855
chr159925085599251056E068-5514
chr159925615099257583E0680
chr159925801299258107E0681442
chr159925816499258560E0681594
chr159925880699259957E0682236
chr159926000299260318E0683432
chr159926034799260481E0683777
chr159926056699260775E0683996
chr159926081299260913E0684242
chr159926104199261160E0684471
chr159926116699261376E0684596
chr159926141899261641E0684848
chr159926172999263007E0685159
chr159926306999263124E0686499
chr159926313099263381E0686560
chr159926344499264219E0686874
chr159926425999264398E0687689
chr159926444899264498E0687878
chr159926450999264679E0687939
chr159926474799264892E0688177
chr159926493099265016E0688360
chr159926508499265508E0688514
chr159926558299265755E0689012
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chr159926595699266252E0689386
chr159926638399266689E0689813
chr159926669799266805E06810127
chr159927050999271871E06813939
chr159927187399272431E06815303
chr159927254599272679E06815975
chr159927273599273542E06816165
chr159927354699273608E06816976
chr159927365099273846E06817080
chr159927390999274042E06817339
chr159927409999274139E06817529
chr159927423899274407E06817668
chr159927442499274741E06817854
chr159927477599274948E06818205
chr159927497299275178E06818402
chr159927722899277302E06820658
chr159927765999278597E06821089
chr159927863899278838E06822068
chr159927906699279526E06822496
chr159927957599279732E06823005
chr159927996199280011E06823391
chr159928002599280070E06823455
chr159928017099280216E06823600
chr159928024999280389E06823679
chr159928306499283108E06826494
chr159928324899283311E06826678
chr159929477499294824E06838204
chr159929504799295368E06838477
chr159930346099304223E06846890
chr159920854099208819E069-47751
chr159920892099209224E069-47346
chr159920928299209346E069-47224
chr159920940999209469E069-47101
chr159921143499212687E069-43883
chr159921271299213080E069-43490
chr159921332699213380E069-43190
chr159921340999213610E069-42960
chr159921375999213823E069-42747
chr159921387399214017E069-42553
chr159921401899214098E069-42472
chr159921410199215478E069-41092
chr159922484999224923E069-31647
chr159922618699226305E069-30265
chr159922631099228127E069-28443
chr159923558999235975E069-20595
chr159923608399236146E069-20424
chr159923621599236825E069-19745
chr159923710899237211E069-19359
chr159923722399237288E069-19282
chr159923749799237888E069-18682
chr159923845599238667E069-17903
chr159923872499239601E069-16969
chr159923964999240070E069-16500
chr159924014799240191E069-16379
chr159924024099240322E069-16248
chr159924034099240594E069-15976
chr159924183799242185E069-14385
chr159924222699243061E069-13509
chr159924355799243607E069-12963
chr159924367199243711E069-12859
chr159924378599243898E069-12672
chr159924390099244066E069-12504
chr159924419099244274E069-12296
chr159924626199246310E069-10260
chr159924633399246428E069-10142
chr159924647599246862E069-9708
chr159924769199248629E069-7941
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chr159925114699251249E069-5321
chr159925141699251992E069-4578
chr159925232599252532E069-4038
chr159925615099257583E0690
chr159925801299258107E0691442
chr159925816499258560E0691594
chr159925880699259957E0692236
chr159926000299260318E0693432
chr159926034799260481E0693777
chr159926056699260775E0693996
chr159926081299260913E0694242
chr159926104199261160E0694471
chr159926116699261376E0694596
chr159926141899261641E0694848
chr159926172999263007E0695159
chr159926306999263124E0696499
chr159926313099263381E0696560
chr159926344499264219E0696874
chr159926425999264398E0697689
chr159926444899264498E0697878
chr159926450999264679E0697939
chr159926474799264892E0698177
chr159926493099265016E0698360
chr159926508499265508E0698514
chr159926558299265755E0699012
chr159926580199265913E0699231
chr159926595699266252E0699386
chr159926638399266689E0699813
chr159927050999271871E06913939
chr159927187399272431E06915303
chr159927254599272679E06915975
chr159927273599273542E06916165
chr159927765999278597E06921089
chr159927996199280011E06923391
chr159928002599280070E06923455
chr159928017099280216E06923600
chr159928024999280389E06923679
chr159928043499280710E06923864
chr159928754399287635E06930973
chr159928766699287966E06931096
chr159928810699288334E06931536
chr159929504799295368E06938477
chr159929543599295534E06938865
chr159929700299298214E06940432
chr159930346099304223E06946890
chr159930429299304494E06947722
chr159930451799304697E06947947
chr159920677799206921E070-49649
chr159920696299207254E070-49316
chr159921054399211433E070-45137
chr159921143499212687E070-43883
chr159921271299213080E070-43490
chr159921332699213380E070-43190
chr159921340999213610E070-42960
chr159921375999213823E070-42747
chr159921387399214017E070-42553
chr159921401899214098E070-42472
chr159921410199215478E070-41092
chr159921659299217206E070-39364
chr159922460199224723E070-31847
chr159922484999224923E070-31647
chr159923031699230727E070-25843
chr159923347899233789E070-22781
chr159923386999234001E070-22569
chr159923403599234091E070-22479
chr159923608399236146E070-20424
chr159923621599236825E070-19745
chr159923710899237211E070-19359
chr159923722399237288E070-19282
chr159923749799237888E070-18682
chr159923803699238308E070-18262
chr159923845599238667E070-17903
chr159924183799242185E070-14385
chr159924222699243061E070-13509
chr159924309999243254E070-13316
chr159924338399243553E070-13017
chr159924355799243607E070-12963
chr159924367199243711E070-12859
chr159924378599243898E070-12672
chr159924390099244066E070-12504
chr159924419099244274E070-12296
chr159924603399246085E070-10485
chr159924626199246310E070-10260
chr159924633399246428E070-10142
chr159924647599246862E070-9708
chr159925615099257583E0700
chr159925801299258107E0701442
chr159925816499258560E0701594
chr159925880699259957E0702236
chr159926000299260318E0703432
chr159926034799260481E0703777
chr159926056699260775E0703996
chr159926081299260913E0704242
chr159926104199261160E0704471
chr159926172999263007E0705159
chr159926306999263124E0706499
chr159926313099263381E0706560
chr159926344499264219E0706874
chr159926425999264398E0707689
chr159926444899264498E0707878
chr159926450999264679E0707939
chr159926474799264892E0708177
chr159926493099265016E0708360
chr159926508499265508E0708514
chr159926558299265755E0709012
chr159926580199265913E0709231
chr159926595699266252E0709386
chr159926638399266689E0709813
chr159926669799266805E07010127
chr159927050999271871E07013939
chr159927187399272431E07015303
chr159927254599272679E07015975
chr159927273599273542E07016165
chr159927996199280011E07023391
chr159928002599280070E07023455
chr159928017099280216E07023600
chr159928024999280389E07023679
chr159928043499280710E07023864
chr159928075899280802E07024188
chr159928096499281248E07024394
chr159928766699287966E07031096
chr159928810699288334E07031536
chr159928846399290348E07031893
chr159929263999292705E07036069
chr159929294799292999E07036377
chr159929308799293146E07036517
chr159929330399293466E07036733
chr159929477499294824E07038204
chr159929504799295368E07038477
chr159930151599301824E07044945
chr159930185499301950E07045284
chr159930217999302229E07045609
chr159930227999302539E07045709
chr159930268499302774E07046114
chr159930346099304223E07046890
chr159930429299304494E07047722
chr159920677799206921E071-49649
chr159920696299207254E071-49316
chr159920737299207416E071-49154
chr159920854099208819E071-47751
chr159920892099209224E071-47346
chr159920928299209346E071-47224
chr159920940999209469E071-47101
chr159920972799210461E071-46109
chr159921143499212687E071-43883
chr159921271299213080E071-43490
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chr159921340999213610E071-42960
chr159921375999213823E071-42747
chr159921387399214017E071-42553
chr159921401899214098E071-42472
chr159921410199215478E071-41092
chr159922484999224923E071-31647
chr159922524199225553E071-31017
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chr159922583899225926E071-30644
chr159922618699226305E071-30265
chr159922631099228127E071-28443
chr159923216699232233E071-24337
chr159923234999232451E071-24119
chr159923621599236825E071-19745
chr159923710899237211E071-19359
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chr159923749799237888E071-18682
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chr159924309999243254E071-13316
chr159924338399243553E071-13017
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chr159924626199246310E071-10260
chr159924633399246428E071-10142
chr159924647599246862E071-9708
chr159924688699246995E071-9575
chr159924900399249502E071-7068
chr159924957699249779E071-6791
chr159925141699251992E071-4578
chr159925615099257583E0710
chr159925801299258107E0711442
chr159925816499258560E0711594
chr159925880699259957E0712236
chr159926000299260318E0713432
chr159926034799260481E0713777
chr159926104199261160E0714471
chr159926116699261376E0714596
chr159926172999263007E0715159
chr159926306999263124E0716499
chr159926313099263381E0716560
chr159926344499264219E0716874
chr159926425999264398E0717689
chr159926444899264498E0717878
chr159926450999264679E0717939
chr159926474799264892E0718177
chr159926493099265016E0718360
chr159926580199265913E0719231
chr159926595699266252E0719386
chr159926638399266689E0719813
chr159926669799266805E07110127
chr159927050999271871E07113939
chr159927187399272431E07115303
chr159927254599272679E07115975
chr159927273599273542E07116165
chr159927354699273608E07116976
chr159927365099273846E07117080
chr159927477599274948E07118205
chr159927497299275178E07118402
chr159927522199275478E07118651
chr159927765999278597E07121089
chr159928367699283770E07127106
chr159928392499284107E07127354
chr159929477499294824E07138204
chr159929504799295368E07138477
chr159929543599295534E07138865
chr159929700299298214E07140432
chr159929846599298627E07141895
chr159930346099304223E07146890
chr159930429299304494E07147722
chr159930451799304697E07147947
chr159930480199304884E07148231
chr159930490199304984E07148331
chr159920677799206921E072-49649
chr159920854099208819E072-47751
chr159920892099209224E072-47346
chr159920928299209346E072-47224
chr159920940999209469E072-47101
chr159921143499212687E072-43883
chr159921271299213080E072-43490
chr159921332699213380E072-43190
chr159921340999213610E072-42960
chr159921375999213823E072-42747
chr159921387399214017E072-42553
chr159921401899214098E072-42472
chr159921410199215478E072-41092
chr159922572499225817E072-30753
chr159922583899225926E072-30644
chr159922618699226305E072-30265
chr159922631099228127E072-28443
chr159922821499228298E072-28272
chr159922846199228659E072-27911
chr159922898799229169E072-27401
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