rs3809622

Homo sapiens
C>G / C>T
MLYCD : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0066 (1985/29994,GnomAD)
T=0068 (2004/29118,TOPMED)
T=0115 (577/5008,1000G)
T=0053 (206/3854,ALSPAC)
T=0055 (204/3708,TWINSUK)
chr16:83897933 (GRCh38.p7) (16q23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
12 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.83897933C>G
GRCh38.p7 chr 16NC_000016.10:g.83897933C>T
GRCh37.p13 chr 16NC_000016.9:g.83931538C>G
GRCh37.p13 chr 16NC_000016.9:g.83931538C>T
MLYCD RefSeqGeneNG_009079.1:g.3809C>G
MLYCD RefSeqGeneNG_009079.1:g.3809C>T

Gene: MLYCD, malonyl-CoA decarboxylase(plus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
MLYCD transcriptNM_012213.2:c.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.911T=0.089
1000GenomesAmericanSub694C=0.880T=0.120
1000GenomesEast AsianSub1008C=0.826T=0.174
1000GenomesEuropeSub1006C=0.943T=0.057
1000GenomesGlobalStudy-wide5008C=0.885T=0.115
1000GenomesSouth AsianSub978C=0.850T=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.947T=0.053
The Genome Aggregation DatabaseAfricanSub8726C=0.927T=0.073
The Genome Aggregation DatabaseAmericanSub838C=0.900T=0.100
The Genome Aggregation DatabaseEast AsianSub1622C=0.818T=0.182
The Genome Aggregation DatabaseEuropeSub18506C=0.948T=0.051
The Genome Aggregation DatabaseGlobalStudy-wide29994C=0.933T=0.066
The Genome Aggregation DatabaseOtherSub302C=0.910T=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.931T=0.068
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.945T=0.055
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs38096220.000851alcohol dependence20201924

eQTL of rs3809622 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3809622 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr166462073464621135E06923407
chr166462115964621309E06923832
chr166456679664567130E071-30197
chr166462040464620625E07123077
chr166462073464621135E07123407
chr166462040464620625E07323077
chr166462073464621135E07323407
chr166462073464621135E07423407
chr166462115964621309E07423832
chr166462040464620625E08123077
chr166462073464621135E08123407
chr166462115964621309E08123832