rs3824435

Homo sapiens
C>T
PLGRKT : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0386 (11505/29798,GnomAD)
T=0441 (12854/29118,TOPMED)
T=0484 (2422/5008,1000G)
T=0311 (1198/3854,ALSPAC)
T=0319 (1182/3708,TWINSUK)
chr9:5377115 (GRCh38.p7) (9p24.1)
AD
GWASCatalog
1   publication(s)
See rs on genome
13 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.5377115C>T
GRCh37.p13 chr 9NC_000009.11:g.5377115C>T

Gene: PLGRKT, plasminogen receptor with a C-terminal lysine(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PLGRKT transcriptNM_018465.3:c.N/AIntron Variant
PLGRKT transcript variant X1XM_005251510.4:c.N/AIntron Variant
PLGRKT transcript variant X3XM_005251512.4:c.N/AIntron Variant
PLGRKT transcript variant X2XM_011517960.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.411T=0.589
1000GenomesAmericanSub694C=0.550T=0.450
1000GenomesEast AsianSub1008C=0.560T=0.440
1000GenomesEuropeSub1006C=0.639T=0.361
1000GenomesGlobalStudy-wide5008C=0.516T=0.484
1000GenomesSouth AsianSub978C=0.470T=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.689T=0.311
The Genome Aggregation DatabaseAfricanSub8672C=0.470T=0.530
The Genome Aggregation DatabaseAmericanSub834C=0.540T=0.460
The Genome Aggregation DatabaseEast AsianSub1608C=0.610T=0.390
The Genome Aggregation DatabaseEuropeSub18382C=0.686T=0.313
The Genome Aggregation DatabaseGlobalStudy-wide29798C=0.613T=0.386
The Genome Aggregation DatabaseOtherSub302C=0.550T=0.450
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.558T=0.441
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.681T=0.319
PMID Title Author Journal
28990359Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.Polimanti RAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs38244356E-08alcohol dependence28990359

eQTL of rs3824435 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3824435 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr953888305389077E06711715
chr953890875389616E06711972
chr953604685360518E069-16597
chr953646905365076E069-12039
chr953626345362734E071-14381
chr953646905365076E071-12039
chr953888305389077E07111715
chr953890875389616E07111972
chr953646905365076E072-12039
chr954234145423494E07346299
chr953646905365076E074-12039
chr953881385388390E07411023
chr953621285362535E081-14580