rs3825388

Homo sapiens
G>A
NAA25 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0072 (2169/29958,GnomAD)
A=0071 (2075/29118,TOPMED)
A=0184 (923/5008,1000G)
A=0004 (14/3854,ALSPAC)
A=0003 (10/3708,TWINSUK)
chr12:112048147 (GRCh38.p7) (12q24.13)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.112048147G>A
GRCh37.p13 chr 12NC_000012.11:g.112485951G>A
NAA25 RefSeqGeneNG_017071.1:g.65685C>T

Gene: NAA25, N(alpha)-acetyltransferase 25, NatB auxiliary subunit(minus strand)

Molecule type Change Amino acid[Codon] SO Term
NAA25 transcriptNM_024953.3:c.N/AIntron Variant
NAA25 transcript variant X2XM_005253938.1:c.N/AIntron Variant
NAA25 transcript variant X1XM_006719606.2:c.N/AIntron Variant
NAA25 transcript variant X3XM_017019977.1:c.N/AIntron Variant
NAA25 transcript variant X4XR_243023.3:n.N/AIntron Variant
NAA25 transcript variant X5XR_944730.2:n.N/AIntron Variant
NAA25 transcript variant X6XR_944731.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.880A=0.120
1000GenomesAmericanSub694G=0.850A=0.150
1000GenomesEast AsianSub1008G=0.426A=0.574
1000GenomesEuropeSub1006G=0.998A=0.002
1000GenomesGlobalStudy-wide5008G=0.816A=0.184
1000GenomesSouth AsianSub978G=0.920A=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.996A=0.004
The Genome Aggregation DatabaseAfricanSub8710G=0.891A=0.109
The Genome Aggregation DatabaseAmericanSub836G=0.820A=0.180
The Genome Aggregation DatabaseEast AsianSub1612G=0.378A=0.622
The Genome Aggregation DatabaseEuropeSub18498G=0.996A=0.003
The Genome Aggregation DatabaseGlobalStudy-wide29958G=0.927A=0.072
The Genome Aggregation DatabaseOtherSub302G=0.990A=0.010
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.928A=0.071
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.997A=0.003
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs38253880.000811alcohol consumption (maxi-drinks)24277619

eQTL of rs3825388 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3825388 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12112449438112449517E067-36434
chr12112456259112456309E067-29642
chr12112456322112456497E067-29454
chr12112456513112456635E067-29316
chr12112456671112457162E067-28789
chr12112457180112457298E067-28653
chr12112449438112449517E068-36434
chr12112453470112453510E068-32441
chr12112503799112504124E06817848
chr12112534059112534157E06848108
chr12112534184112534865E06848233
chr12112449438112449517E070-36434
chr12112445457112445578E071-40373
chr12112445610112445660E071-40291
chr12112449438112449517E071-36434
chr12112454969112455363E071-30588
chr12112487127112487183E0711176
chr12112503799112504124E07117848
chr12112528474112528554E07142523
chr12112445457112445578E072-40373
chr12112445610112445660E072-40291
chr12112448648112448833E072-37118
chr12112449005112449094E072-36857
chr12112449105112449163E072-36788
chr12112449168112449400E072-36551
chr12112449438112449517E072-36434
chr12112454969112455363E072-30588
chr12112503799112504124E07217848
chr12112528084112528366E07242133
chr12112449005112449094E073-36857
chr12112449105112449163E073-36788
chr12112449168112449400E073-36551
chr12112449438112449517E073-36434
chr12112452966112453016E073-32935
chr12112453283112453439E073-32512
chr12112453470112453510E073-32441
chr12112453539112453609E073-32342
chr12112534184112534865E07348233
chr12112449005112449094E074-36857
chr12112449105112449163E074-36788
chr12112449168112449400E074-36551
chr12112449438112449517E074-36434
chr12112485811112485933E074-18
chr12112486117112486205E074166
chr12112503799112504124E07417848
chr12112528084112528366E07442133
chr12112528474112528554E07442523
chr12112449438112449517E081-36434
chr12112449168112449400E082-36551
chr12112449438112449517E082-36434
chr12112453470112453510E082-32441
chr12112525442112525502E08239491









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr12112450339112452718E067-33233
chr12112450339112452718E068-33233
chr12112450339112452718E069-33233
chr12112450339112452718E070-33233
chr12112450339112452718E071-33233
chr12112450339112452718E072-33233
chr12112450339112452718E073-33233
chr12112450339112452718E074-33233
chr12112450339112452718E081-33233
chr12112450339112452718E082-33233