rs3856567

Homo sapiens
A>G
CRYBG3 : Intron Variant
LOC105373994 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0457 (13641/29828,GnomAD)
G=0431 (12560/29118,TOPMED)
G=0474 (2375/5008,1000G)
A==0487 (1878/3854,ALSPAC)
A==0489 (1814/3708,TWINSUK)
chr3:97864832 (GRCh38.p7) (3q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
64 Enhancers around
32 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.97864832A>G
GRCh37.p13 chr 3NC_000003.11:g.97583676A>G

Gene: CRYBG3, crystallin beta-gamma domain containing 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
CRYBG3 transcriptNM_153605.3:c.N/AIntron Variant
CRYBG3 transcript variant X1XM_005247117.4:c.N/AIntron Variant
CRYBG3 transcript variant X2XR_001740014.1:n.N/AIntron Variant

Gene: LOC105373994, uncharacterized LOC105373994(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105373994 transcript variant X1XR_001740811.1:n.N/AIntron Variant
LOC105373994 transcript variant X2XR_001740812.1:n.N/AIntron Variant
LOC105373994 transcript variant X3XR_001740813.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.747G=0.253
1000GenomesAmericanSub694A=0.500G=0.500
1000GenomesEast AsianSub1008A=0.322G=0.678
1000GenomesEuropeSub1006A=0.491G=0.509
1000GenomesGlobalStudy-wide5008A=0.526G=0.474
1000GenomesSouth AsianSub978A=0.490G=0.510
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.487G=0.513
The Genome Aggregation DatabaseAfricanSub8688A=0.715G=0.285
The Genome Aggregation DatabaseAmericanSub832A=0.440G=0.560
The Genome Aggregation DatabaseEast AsianSub1606A=0.322G=0.678
The Genome Aggregation DatabaseEuropeSub18404A=0.486G=0.513
The Genome Aggregation DatabaseGlobalStudy-wide29828A=0.542G=0.457
The Genome Aggregation DatabaseOtherSub298A=0.450G=0.550
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.568G=0.431
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.489G=0.511
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs38565670.000538alcohol dependence20201924

eQTL of rs3856567 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs3856567 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr39754406897544211E067-39465
chr39754424097544339E067-39337
chr39754676397546840E067-36836
chr39759071597591785E0677039
chr39754319397543337E068-40339
chr39754343197543481E068-40195
chr39754366597543715E068-39961
chr39754380897543861E068-39815
chr39754386397543974E068-39702
chr39754406897544211E068-39465
chr39754424097544339E068-39337
chr39755701497557072E068-26604
chr39755731697557530E068-26146
chr39758149497581604E068-2072
chr39758165697581714E068-1962
chr39758181297581903E068-1773
chr39758190797582242E068-1434
chr39759071597591785E0687039
chr39759180397591922E0688127
chr39754319397543337E069-40339
chr39754366597543715E069-39961
chr39754380897543861E069-39815
chr39754386397543974E069-39702
chr39754406897544211E069-39465
chr39754424097544339E069-39337
chr39754676397546840E069-36836
chr39755880497558854E069-24822
chr39759014697590300E0696470
chr39759071597591785E0697039
chr39760174997602433E06918073
chr39753571197535976E070-47700
chr39754319397543337E071-40339
chr39754343197543481E071-40195
chr39754366597543715E071-39961
chr39754380897543861E071-39815
chr39754386397543974E071-39702
chr39754406897544211E071-39465
chr39754424097544339E071-39337
chr39754676397546840E071-36836
chr39754957297549758E071-33918
chr39754984197549916E071-33760
chr39754366597543715E072-39961
chr39754380897543861E072-39815
chr39754386397543974E072-39702
chr39754406897544211E072-39465
chr39754424097544339E072-39337
chr39755903497559084E072-24592
chr39759071597591785E0727039
chr39760174997602433E07218073
chr39753982997539940E073-43736
chr39754676397546840E073-36836
chr39754343197543481E074-40195
chr39754366597543715E074-39961
chr39754380897543861E074-39815
chr39754386397543974E074-39702
chr39754406897544211E074-39465
chr39754424097544339E074-39337
chr39754676397546840E074-36836
chr39755880497558854E074-24822
chr39759071597591785E0747039
chr39759180397591922E0748127
chr39760174997602433E07418073
chr39760251197602561E07418835
chr39753982997539940E081-43736









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr39753999797541749E067-41927
chr39754175297541958E067-41718
chr39754196697542798E067-40878
chr39754291197542961E067-40715
chr39753999797541749E068-41927
chr39754175297541958E068-41718
chr39754196697542798E068-40878
chr39754291197542961E068-40715
chr39753999797541749E069-41927
chr39754175297541958E069-41718
chr39754196697542798E069-40878
chr39754291197542961E069-40715
chr39753999797541749E071-41927
chr39754175297541958E071-41718
chr39754196697542798E071-40878
chr39754291197542961E071-40715
chr39753999797541749E072-41927
chr39754175297541958E072-41718
chr39754196697542798E072-40878
chr39754291197542961E072-40715
chr39753999797541749E073-41927
chr39754175297541958E073-41718
chr39754196697542798E073-40878
chr39754291197542961E073-40715
chr39753999797541749E074-41927
chr39754175297541958E074-41718
chr39754196697542798E074-40878
chr39754291197542961E074-40715
chr39753999797541749E081-41927
chr39754196697542798E081-40878
chr39753999797541749E082-41927
chr39754175297541958E082-41718