rs388337

Homo sapiens
C>T
ARL15 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0272 (8144/29888,GnomAD)
C==0270 (7867/29118,TOPMED)
C==0352 (1765/5008,1000G)
C==0262 (1009/3854,ALSPAC)
C==0254 (942/3708,TWINSUK)
chr5:54261708 (GRCh38.p7) (5q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
32 Enhancers around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.54261708C>T
GRCh37.p13 chr 5NC_000005.9:g.53557538C>T

Gene: ARL15, ADP ribosylation factor like GTPase 15(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL15 transcriptNM_019087.2:c.N/AIntron Variant
ARL15 transcript variant X1XM_011543498.2:c.N/AIntron Variant
ARL15 transcript variant X2XM_011543499.2:c.N/AIntron Variant
ARL15 transcript variant X3XM_011543500.2:c.N/AIntron Variant
ARL15 transcript variant X4XM_017009598.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.234T=0.766
1000GenomesAmericanSub694C=0.480T=0.520
1000GenomesEast AsianSub1008C=0.553T=0.447
1000GenomesEuropeSub1006C=0.253T=0.747
1000GenomesGlobalStudy-wide5008C=0.352T=0.648
1000GenomesSouth AsianSub978C=0.320T=0.680
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.262T=0.738
The Genome Aggregation DatabaseAfricanSub8696C=0.234T=0.766
The Genome Aggregation DatabaseAmericanSub836C=0.500T=0.500
The Genome Aggregation DatabaseEast AsianSub1600C=0.580T=0.420
The Genome Aggregation DatabaseEuropeSub18454C=0.254T=0.745
The Genome Aggregation DatabaseGlobalStudy-wide29888C=0.272T=0.727
The Genome Aggregation DatabaseOtherSub302C=0.210T=0.790
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.270T=0.729
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.254T=0.746
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs3883375.9E-06alcohol dependence (age at onset)24962325

eQTL of rs388337 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs388337 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr55359219153592302E06734653
chr55359230553592489E06734767
chr55360474653604828E06747208
chr55352492153525456E068-32082
chr55359156353591979E06834025
chr55359219153592302E06834653
chr55359230553592489E06834767
chr55357394153574185E06916403
chr55357422253574433E06916684
chr55351066653510874E070-46664
chr55351115053511650E070-45888
chr55351327153513323E070-44215
chr55360335753603465E07045819
chr55360351753603786E07045979
chr55360440353604546E07046865
chr55360474653604828E07147208
chr55357394153574185E07216403
chr55357422253574433E07216684
chr55357444553574505E07216907
chr55357422253574433E07416684
chr55357444553574505E07416907
chr55359119253591246E07433654
chr55359156353591979E07434025
chr55359219153592302E07434653
chr55359230553592489E07434767
chr55351066653510874E081-46664
chr55351115053511650E081-45888
chr55360351753603786E08145979
chr55360427953604329E08146741
chr55360440353604546E08146865
chr55360474653604828E08147208
chr55351115053511650E082-45888









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr55355060653550896E071-6642