rs389674

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0334 (9995/29906,GnomAD)
C==0352 (10261/29118,TOPMED)
C==0357 (1788/5008,1000G)
C==0252 (973/3854,ALSPAC)
C==0255 (947/3708,TWINSUK)
chr6:147491880 (GRCh38.p7) (6q24.3)
ND
GWASdb2
1   publication(s)
See rs on genome
14 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.147491880C>T
GRCh37.p13 chr 6NC_000006.11:g.147813016C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.532T=0.468
1000GenomesAmericanSub694C=0.330T=0.670
1000GenomesEast AsianSub1008C=0.233T=0.767
1000GenomesEuropeSub1006C=0.269T=0.731
1000GenomesGlobalStudy-wide5008C=0.357T=0.643
1000GenomesSouth AsianSub978C=0.360T=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.252T=0.748
The Genome Aggregation DatabaseAfricanSub8710C=0.467T=0.533
The Genome Aggregation DatabaseAmericanSub836C=0.350T=0.650
The Genome Aggregation DatabaseEast AsianSub1612C=0.212T=0.788
The Genome Aggregation DatabaseEuropeSub18446C=0.281T=0.718
The Genome Aggregation DatabaseGlobalStudy-wide29906C=0.334T=0.665
The Genome Aggregation DatabaseOtherSub302C=0.340T=0.660
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.352T=0.647
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.255T=0.745
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs3896740.000785nicotine dependence17158188

eQTL of rs389674 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs389674 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6147797680147797917E068-15099
chr6147768276147768453E070-44563
chr6147768496147768764E070-44252
chr6147768771147769292E070-43724
chr6147769962147770075E070-42941
chr6147770162147770248E070-42768
chr6147770367147770500E070-42516
chr6147824746147825106E07011730
chr6147769342147769930E071-43086
chr6147769962147770075E071-42941
chr6147797161147797321E071-15695
chr6147797680147797917E071-15099
chr6147797680147797917E072-15099
chr6147797680147797917E074-15099





Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr6147827750147831995E06714734
chr6147827750147831995E06814734
chr6147827750147831995E06914734
chr6147827750147831995E07114734
chr6147827750147831995E07214734
chr6147827750147831995E07314734
chr6147827750147831995E07414734
chr6147827750147831995E08214734