rs403334

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0196 (5878/29924,GnomAD)
T==0178 (5207/29118,TOPMED)
T==0132 (660/5008,1000G)
T==0228 (877/3854,ALSPAC)
T==0223 (826/3708,TWINSUK)
chr5:158669643 (GRCh38.p7) (5q33.3)
AD
GWASdb2
1   publication(s)
See rs on genome
5 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.158669643T>G
GRCh37.p13 chr 5NC_000005.9:g.158096651T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.144G=0.856
1000GenomesAmericanSub694T=0.160G=0.840
1000GenomesEast AsianSub1008T=0.044G=0.956
1000GenomesEuropeSub1006T=0.188G=0.812
1000GenomesGlobalStudy-wide5008T=0.132G=0.868
1000GenomesSouth AsianSub978T=0.130G=0.870
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.228G=0.772
The Genome Aggregation DatabaseAfricanSub8722T=0.158G=0.842
The Genome Aggregation DatabaseAmericanSub834T=0.160G=0.840
The Genome Aggregation DatabaseEast AsianSub1614T=0.042G=0.958
The Genome Aggregation DatabaseEuropeSub18452T=0.230G=0.769
The Genome Aggregation DatabaseGlobalStudy-wide29924T=0.196G=0.803
The Genome Aggregation DatabaseOtherSub302T=0.170G=0.830
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.178G=0.821
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.223G=0.777
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs4033340.000713alcohol dependence20201924

eQTL of rs403334 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs403334 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5158122253158122453E06725602
chr5158122485158123202E06725834
chr5158067028158067176E070-29475
chr5158067307158067449E070-29202
chr5158123940158124159E08127289