rs4073735

Homo sapiens
C>T
ROR2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0474 (14192/29908,GnomAD)
C==0433 (12622/29118,TOPMED)
C==0435 (2180/5008,1000G)
T=0452 (1741/3854,ALSPAC)
T=0451 (1671/3708,TWINSUK)
chr9:91726133 (GRCh38.p7) (9q22.31)
AD
GWASdb2
2   publication(s)
See rs on genome
9 Enhancers around
12 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.91726133C>T
GRCh37.p13 chr 9NC_000009.11:g.94488415C>T
ROR2 RefSeqGeneNG_008089.1:g.229030G>A

Gene: ROR2, receptor tyrosine kinase like orphan receptor 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ROR2 transcript variant 1NM_004560.3:c.N/AIntron Variant
ROR2 transcript variant 2NM_001318204.1:c.N/AGenic Downstream Transcript Variant
ROR2 transcript variant X2XM_005252008.4:c.N/AIntron Variant
ROR2 transcript variant X5XM_005252009.3:c.N/AIntron Variant
ROR2 transcript variant X3XM_006717121.3:c.N/AIntron Variant
ROR2 transcript variant X1XM_017014762.1:c.N/AIntron Variant
ROR2 transcript variant X4XM_017014763.1:c.N/AIntron Variant
ROR2 transcript variant X6XR_001746315.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.262T=0.738
1000GenomesAmericanSub694C=0.620T=0.380
1000GenomesEast AsianSub1008C=0.447T=0.553
1000GenomesEuropeSub1006C=0.562T=0.438
1000GenomesGlobalStudy-wide5008C=0.435T=0.565
1000GenomesSouth AsianSub978C=0.400T=0.600
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.548T=0.452
The Genome Aggregation DatabaseAfricanSub8708C=0.307T=0.693
The Genome Aggregation DatabaseAmericanSub836C=0.590T=0.410
The Genome Aggregation DatabaseEast AsianSub1610C=0.427T=0.573
The Genome Aggregation DatabaseEuropeSub18452C=0.551T=0.448
The Genome Aggregation DatabaseGlobalStudy-wide29908C=0.474T=0.525
The Genome Aggregation DatabaseOtherSub302C=0.530T=0.470
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.433T=0.566
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.549T=0.451
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res
24149131Candidate gene analysis in israeli soldiers with stress fractures.Yanovich RJ Sports Sci Med

P-Value

SNP ID p-value Traits Study
rs40737350.000765alcohol dependence21314694

eQTL of rs4073735 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4073735 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr99445322494453434E070-34981
chr99447501094475050E070-13365
chr99447517894475255E070-13160
chr99447501094475050E071-13365
chr99447517894475255E071-13160
chr99443966194439996E081-48419
chr99444006794440207E081-48208
chr99444449694444608E081-43807
chr99453266594533064E08144250



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr99444376594444383E067-44032
chr99444376594444383E068-44032
chr99444376594444383E069-44032
chr99444376594444383E071-44032
chr99447656994477079E071-11336
chr99444376594444383E072-44032
chr99447656994477079E072-11336
chr99447712394477208E072-11207
chr99444376594444383E073-44032
chr99444376594444383E082-44032
chr99447656994477079E082-11336
chr99447712394477208E082-11207