rs4132568

Homo sapiens
A>C
LOC105375411 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0489 (14614/29864,GnomAD)
C=0434 (12636/29118,TOPMED)
A==0478 (2394/5008,1000G)
A==0450 (1735/3854,ALSPAC)
A==0466 (1727/3708,TWINSUK)
chr7:96505669 (GRCh38.p7) (7q21.3)
ND
GWASCatalog
1   publication(s)
See rs on genome
49 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.96505669A>C
GRCh37.p13 chr 7NC_000007.13:g.96134981A>C

Gene: LOC105375411, uncharacterized LOC105375411(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105375411 transcript variant X1XR_927780.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.683C=0.317
1000GenomesAmericanSub694A=0.420C=0.580
1000GenomesEast AsianSub1008A=0.300C=0.700
1000GenomesEuropeSub1006A=0.481C=0.519
1000GenomesGlobalStudy-wide5008A=0.478C=0.522
1000GenomesSouth AsianSub978A=0.420C=0.580
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.450C=0.550
The Genome Aggregation DatabaseAfricanSub8694A=0.669C=0.331
The Genome Aggregation DatabaseAmericanSub832A=0.330C=0.670
The Genome Aggregation DatabaseEast AsianSub1588A=0.321C=0.679
The Genome Aggregation DatabaseEuropeSub18448A=0.460C=0.539
The Genome Aggregation DatabaseGlobalStudy-wide29864A=0.510C=0.489
The Genome Aggregation DatabaseOtherSub302A=0.500C=0.500
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.566C=0.434
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.466C=0.534
PMID Title Author Journal
25293881The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.Patel YMCancer Epidemiol Biomarkers Prev

P-Value

SNP ID p-value Traits Study
rs41325683E-08nicotine glucouronidation25293881

eQTL of rs4132568 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4132568 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr79615649296156965E06721511
chr79615577296156111E06820791
chr79615649296156965E06821511
chr79615708996157282E06822108
chr79615577296156111E06920791
chr79615649296156965E06921511
chr79615708996157282E06922108
chr79617639496176466E06941413
chr79617663896177161E06941657
chr79609364996093730E070-41251
chr79609400396094053E070-40928
chr79609418196094231E070-40750
chr79612488496125177E070-9804
chr79612518596125423E070-9558
chr79613746896137523E0702487
chr79613767596138002E0702694
chr79613807096138139E0703089
chr79617454196174614E07039560
chr79617464896174928E07039667
chr79617503796175136E07040056
chr79617539396175493E07040412
chr79617581996176131E07040838
chr79617639496176466E07041413
chr79617663896177161E07041657
chr79617750696177586E07042525
chr79617802396178369E07043042
chr79617861996178669E07043638
chr79611167096111720E071-23261
chr79611219596112286E071-22695
chr79615577296156111E07120791
chr79615649296156965E07121511
chr79615708996157282E07122108
chr79615743196157481E07122450
chr79617639496176466E07141413
chr79617663896177161E07141657
chr79615577296156111E07220791
chr79615649296156965E07221511
chr79617663896177161E07241657
chr79615577296156111E07420791
chr79615649296156965E07421511
chr79615708996157282E07422108
chr79615743196157481E07422450
chr79617503796175136E08140056
chr79617750696177586E08142525
chr79617539396175493E08240412
chr79617581996176131E08240838
chr79617639496176466E08241413
chr79617663896177161E08241657
chr79617750696177586E08242525